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Side-by-side financial comparison of Aclaris Therapeutics, Inc. (ACRS) and ASTRAZENECA PLC (AZN). Click either name above to swap in a different company.
ASTRAZENECA PLC is the larger business by last-quarter revenue ($14.5B vs $1.3M, roughly 11163.7× Aclaris Therapeutics, Inc.). ASTRAZENECA PLC runs the higher net margin — 16.9% vs -1528.6%, a 1545.5% gap on every dollar of revenue. On growth, ASTRAZENECA PLC posted the faster year-over-year revenue change (11.7% vs -85.9%).
Aclaris Therapeutics, Inc. is a clinical-stage biopharmaceutical firm focused on developing targeted therapies for immunological, inflammatory, and dermatological diseases. Its pipeline includes candidates for unmet needs like alopecia areata and vitiligo, serving global patient groups.
AstraZeneca plc (AZ) is a Swedish-British multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, UK. It has a portfolio of products for major diseases in areas including oncology, cardiovascular, gastrointestinal, infection, neuroscience, respiratory, and inflammation.
ACRS vs AZN — Head-to-Head
Income Statement — Q4 2025 vs Q2 2025
| Metric | | |
|---|---|---|
| Revenue | $1.3M | $14.5B |
| Net Profit | $-19.8M | $2.4B |
| Gross Margin | 58.9% | 82.9% |
| Operating Margin | -1755.5% | 24.3% |
| Net Margin | -1528.6% | 16.9% |
| Revenue YoY | -85.9% | 11.7% |
| Net Profit YoY | 79.5% | 27.0% |
| EPS (diluted) | $-0.16 | $1.57 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $1.3M | — | ||
| Q3 25 | $3.3M | — | ||
| Q2 25 | $1.8M | $14.5B | ||
| Q1 25 | $1.5M | — | ||
| Q4 24 | $9.2M | — | ||
| Q3 24 | $4.3M | — | ||
| Q2 24 | $2.8M | $12.9B | ||
| Q1 24 | $2.4M | — |
| Q4 25 | $-19.8M | — | ||
| Q3 25 | $-14.6M | — | ||
| Q2 25 | $-15.4M | $2.4B | ||
| Q1 25 | $-15.1M | — | ||
| Q4 24 | $-96.6M | — | ||
| Q3 24 | $-7.6M | — | ||
| Q2 24 | $-11.0M | $1.9B | ||
| Q1 24 | $-16.9M | — |
| Q4 25 | 58.9% | — | ||
| Q3 25 | 83.7% | — | ||
| Q2 25 | 71.0% | 82.9% | ||
| Q1 25 | 65.2% | — | ||
| Q4 24 | 92.3% | — | ||
| Q3 24 | 85.0% | — | ||
| Q2 24 | 77.4% | 83.1% | ||
| Q1 24 | 66.3% | — |
| Q4 25 | -1755.5% | — | ||
| Q3 25 | -519.8% | — | ||
| Q2 25 | -1035.9% | 24.3% | ||
| Q1 25 | -1242.9% | — | ||
| Q4 24 | -1082.3% | — | ||
| Q3 24 | -240.9% | — | ||
| Q2 24 | -464.7% | 21.2% | ||
| Q1 24 | -789.4% | — |
| Q4 25 | -1528.6% | — | ||
| Q3 25 | -443.0% | — | ||
| Q2 25 | -868.3% | 16.9% | ||
| Q1 25 | -1036.8% | — | ||
| Q4 24 | -1048.3% | — | ||
| Q3 24 | -174.6% | — | ||
| Q2 24 | -397.2% | 14.9% | ||
| Q1 24 | -706.5% | — |
| Q4 25 | $-0.16 | — | ||
| Q3 25 | $-0.12 | — | ||
| Q2 25 | $-0.13 | $1.57 | ||
| Q1 25 | $-0.12 | — | ||
| Q4 24 | $-1.21 | — | ||
| Q3 24 | $-0.11 | — | ||
| Q2 24 | $-0.15 | $1.24 | ||
| Q1 24 | $-0.24 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $20.0M | $7.1B |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $103.1M | $44.8B |
| Total Assets | $160.5M | $112.4B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $20.0M | — | ||
| Q3 25 | $25.3M | — | ||
| Q2 25 | $25.4M | $7.1B | ||
| Q1 25 | $30.4M | — | ||
| Q4 24 | $24.6M | — | ||
| Q3 24 | $47.7M | — | ||
| Q2 24 | $22.8M | $6.9B | ||
| Q1 24 | $35.8M | — |
| Q4 25 | $103.1M | — | ||
| Q3 25 | $120.1M | — | ||
| Q2 25 | $131.7M | $44.8B | ||
| Q1 25 | $144.1M | — | ||
| Q4 24 | $155.6M | — | ||
| Q3 24 | $130.2M | — | ||
| Q2 24 | $133.8M | $39.6B | ||
| Q1 24 | $142.0M | — |
| Q4 25 | $160.5M | — | ||
| Q3 25 | $175.5M | — | ||
| Q2 25 | $189.1M | $112.4B | ||
| Q1 25 | $198.1M | — | ||
| Q4 24 | $220.3M | — | ||
| Q3 24 | $182.4M | — | ||
| Q2 24 | $161.1M | $104.3B | ||
| Q1 24 | $174.1M | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-13.1M | — |
| Free Cash FlowOCF − Capex | $-13.2M | — |
| FCF MarginFCF / Revenue | -1015.8% | — |
| Capex IntensityCapex / Revenue | 1.9% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-47.2M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-13.1M | — | ||
| Q3 25 | $-10.9M | — | ||
| Q2 25 | $-10.0M | — | ||
| Q1 25 | $-13.1M | — | ||
| Q4 24 | $-8.9M | — | ||
| Q3 24 | $22.0M | — | ||
| Q2 24 | $-12.3M | — | ||
| Q1 24 | $-20.8M | — |
| Q4 25 | $-13.2M | — | ||
| Q3 25 | $-11.0M | — | ||
| Q2 25 | $-10.0M | — | ||
| Q1 25 | $-13.1M | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | $-12.3M | — | ||
| Q1 24 | $-20.9M | — |
| Q4 25 | -1015.8% | — | ||
| Q3 25 | -332.1% | — | ||
| Q2 25 | -563.5% | — | ||
| Q1 25 | -900.3% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | -446.0% | — | ||
| Q1 24 | -873.6% | — |
| Q4 25 | 1.9% | — | ||
| Q3 25 | 0.7% | — | ||
| Q2 25 | 1.2% | — | ||
| Q1 25 | 3.0% | — | ||
| Q4 24 | 0.0% | — | ||
| Q3 24 | 0.0% | — | ||
| Q2 24 | 0.5% | — | ||
| Q1 24 | 5.6% | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
