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Side-by-side financial comparison of Aclaris Therapeutics, Inc. (ACRS) and Zoetis (ZTS). Click either name above to swap in a different company.
Zoetis is the larger business by last-quarter revenue ($2.4B vs $1.3M, roughly 1843.2× Aclaris Therapeutics, Inc.). Zoetis runs the higher net margin — 25.3% vs -1528.6%, a 1553.8% gap on every dollar of revenue. On growth, Zoetis posted the faster year-over-year revenue change (3.0% vs -85.9%). Zoetis produced more free cash flow last quarter ($732.0M vs $-13.2M). Over the past eight quarters, Zoetis's revenue compounded faster (4.4% CAGR vs -26.5%).
Aclaris Therapeutics, Inc. is a clinical-stage biopharmaceutical firm focused on developing targeted therapies for immunological, inflammatory, and dermatological diseases. Its pipeline includes candidates for unmet needs like alopecia areata and vitiligo, serving global patient groups.
Zoetis Inc. (/zō-EH-tis/) is an American drug company, the world's largest producer of medicine and vaccinations for pets and livestock. The company was a subsidiary of Pfizer, the world's largest drug maker, but with Pfizer's spinoff of its 83% interest in the firm it is now a completely independent company. The company directly markets its products in approximately 45 countries, and sells them in more than 100 countries. Operations outside the United States accounted for 50% of the total re...
ACRS vs ZTS — Head-to-Head
Income Statement — Q4 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $1.3M | $2.4B |
| Net Profit | $-19.8M | $603.0M |
| Gross Margin | 58.9% | 70.2% |
| Operating Margin | -1755.5% | 31.9% |
| Net Margin | -1528.6% | 25.3% |
| Revenue YoY | -85.9% | 3.0% |
| Net Profit YoY | 79.5% | 3.8% |
| EPS (diluted) | $-0.16 | $1.37 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $1.3M | $2.4B | ||
| Q3 25 | $3.3M | $2.4B | ||
| Q2 25 | $1.8M | $2.5B | ||
| Q1 25 | $1.5M | $2.2B | ||
| Q4 24 | $9.2M | $2.3B | ||
| Q3 24 | $4.3M | $2.4B | ||
| Q2 24 | $2.8M | $2.4B | ||
| Q1 24 | $2.4M | $2.2B |
| Q4 25 | $-19.8M | $603.0M | ||
| Q3 25 | $-14.6M | $721.0M | ||
| Q2 25 | $-15.4M | $718.0M | ||
| Q1 25 | $-15.1M | $631.0M | ||
| Q4 24 | $-96.6M | $581.0M | ||
| Q3 24 | $-7.6M | $682.0M | ||
| Q2 24 | $-11.0M | $624.0M | ||
| Q1 24 | $-16.9M | $599.0M |
| Q4 25 | 58.9% | 70.2% | ||
| Q3 25 | 83.7% | 71.5% | ||
| Q2 25 | 71.0% | 73.6% | ||
| Q1 25 | 65.2% | 72.0% | ||
| Q4 24 | 92.3% | 69.5% | ||
| Q3 24 | 85.0% | 70.6% | ||
| Q2 24 | 77.4% | 71.7% | ||
| Q1 24 | 66.3% | 70.6% |
| Q4 25 | -1755.5% | 31.9% | ||
| Q3 25 | -519.8% | 37.0% | ||
| Q2 25 | -1035.9% | 36.7% | ||
| Q1 25 | -1242.9% | 36.5% | ||
| Q4 24 | -1082.3% | 31.6% | ||
| Q3 24 | -240.9% | 36.6% | ||
| Q2 24 | -464.7% | 33.0% | ||
| Q1 24 | -789.4% | 34.1% |
| Q4 25 | -1528.6% | 25.3% | ||
| Q3 25 | -443.0% | 30.0% | ||
| Q2 25 | -868.3% | 29.2% | ||
| Q1 25 | -1036.8% | 28.4% | ||
| Q4 24 | -1048.3% | 25.1% | ||
| Q3 24 | -174.6% | 28.6% | ||
| Q2 24 | -397.2% | 26.4% | ||
| Q1 24 | -706.5% | 27.4% |
| Q4 25 | $-0.16 | $1.37 | ||
| Q3 25 | $-0.12 | $1.63 | ||
| Q2 25 | $-0.13 | $1.61 | ||
| Q1 25 | $-0.12 | $1.41 | ||
| Q4 24 | $-1.21 | $1.29 | ||
| Q3 24 | $-0.11 | $1.50 | ||
| Q2 24 | $-0.15 | $1.37 | ||
| Q1 24 | $-0.24 | $1.31 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $20.0M | — |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $103.1M | $3.3B |
| Total Assets | $160.5M | $15.5B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $20.0M | — | ||
| Q3 25 | $25.3M | $2.1B | ||
| Q2 25 | $25.4M | $1.4B | ||
| Q1 25 | $30.4M | $1.7B | ||
| Q4 24 | $24.6M | $2.0B | ||
| Q3 24 | $47.7M | $1.7B | ||
| Q2 24 | $22.8M | $1.6B | ||
| Q1 24 | $35.8M | $2.0B |
| Q4 25 | $103.1M | $3.3B | ||
| Q3 25 | $120.1M | $5.4B | ||
| Q2 25 | $131.7M | $5.0B | ||
| Q1 25 | $144.1M | $4.7B | ||
| Q4 24 | $155.6M | $4.8B | ||
| Q3 24 | $130.2M | $5.2B | ||
| Q2 24 | $133.8M | $5.0B | ||
| Q1 24 | $142.0M | $5.1B |
| Q4 25 | $160.5M | $15.5B | ||
| Q3 25 | $175.5M | $15.2B | ||
| Q2 25 | $189.1M | $14.5B | ||
| Q1 25 | $198.1M | $14.1B | ||
| Q4 24 | $220.3M | $14.2B | ||
| Q3 24 | $182.4M | $14.4B | ||
| Q2 24 | $161.1M | $14.2B | ||
| Q1 24 | $174.1M | $14.3B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-13.1M | $893.0M |
| Free Cash FlowOCF − Capex | $-13.2M | $732.0M |
| FCF MarginFCF / Revenue | -1015.8% | 30.7% |
| Capex IntensityCapex / Revenue | 1.9% | 6.7% |
| Cash ConversionOCF / Net Profit | — | 1.48× |
| TTM Free Cash FlowTrailing 4 quarters | $-47.2M | $2.3B |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-13.1M | $893.0M | ||
| Q3 25 | $-10.9M | $938.0M | ||
| Q2 25 | $-10.0M | $486.0M | ||
| Q1 25 | $-13.1M | $587.0M | ||
| Q4 24 | $-8.9M | $905.0M | ||
| Q3 24 | $22.0M | $951.0M | ||
| Q2 24 | $-12.3M | $502.0M | ||
| Q1 24 | $-20.8M | $595.0M |
| Q4 25 | $-13.2M | $732.0M | ||
| Q3 25 | $-11.0M | $805.0M | ||
| Q2 25 | $-10.0M | $308.0M | ||
| Q1 25 | $-13.1M | $438.0M | ||
| Q4 24 | — | $689.0M | ||
| Q3 24 | — | $784.0M | ||
| Q2 24 | $-12.3M | $370.0M | ||
| Q1 24 | $-20.9M | $455.0M |
| Q4 25 | -1015.8% | 30.7% | ||
| Q3 25 | -332.1% | 33.5% | ||
| Q2 25 | -563.5% | 12.5% | ||
| Q1 25 | -900.3% | 19.7% | ||
| Q4 24 | — | 29.7% | ||
| Q3 24 | — | 32.8% | ||
| Q2 24 | -446.0% | 15.7% | ||
| Q1 24 | -873.6% | 20.8% |
| Q4 25 | 1.9% | 6.7% | ||
| Q3 25 | 0.7% | 5.5% | ||
| Q2 25 | 1.2% | 7.2% | ||
| Q1 25 | 3.0% | 6.7% | ||
| Q4 24 | 0.0% | 9.3% | ||
| Q3 24 | 0.0% | 7.0% | ||
| Q2 24 | 0.5% | 5.6% | ||
| Q1 24 | 5.6% | 6.4% |
| Q4 25 | — | 1.48× | ||
| Q3 25 | — | 1.30× | ||
| Q2 25 | — | 0.68× | ||
| Q1 25 | — | 0.93× | ||
| Q4 24 | — | 1.56× | ||
| Q3 24 | — | 1.39× | ||
| Q2 24 | — | 0.80× | ||
| Q1 24 | — | 0.99× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ACRS
Segment breakdown not available.
ZTS
| Other | $1.3B | 56% |
| Livestock | $234.0M | 10% |
| Pain Sedation | $209.0M | 9% |
| Other Pharmaceuticals | $188.0M | 8% |
| Swine | $125.0M | 5% |
| Poultry | $117.0M | 5% |
| Fish | $81.0M | 3% |
| Other Non Pharmaceuticals | $70.0M | 3% |
| Manufactured Product Other | $18.0M | 1% |
| Medicated Feed Additives | $12.0M | 1% |
