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Side-by-side financial comparison of Enact Holdings, Inc. (ACT) and Ascendis Pharma A/S (ASND). Click either name above to swap in a different company.

Enact Holdings, Inc. is the larger business by last-quarter revenue ($312.7M vs $267.3M, roughly 1.2× Ascendis Pharma A/S). On growth, Ascendis Pharma A/S posted the faster year-over-year revenue change (42.3% vs 3.6%). Over the past eight quarters, Ascendis Pharma A/S's revenue compounded faster (60.7% CAGR vs 3.6%).

Enact Holdings, Inc. is a leading U.S.-based private mortgage insurance provider. It delivers risk mitigation solutions to residential mortgage lenders, banks, and credit unions, enabling borrowers with smaller down payments to access affordable home financing, and supports sustainable homeownership for diverse consumer groups across the United States.

Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication—it is one form of hormone therapy. Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, growth hormone was extracted from human pituitary glands. Growth hormone is now produced by recombinant DNA technology and is prescribed for a variety of reasons. GH therapy has been a focus of social and ethical controversies for 50 years.

ACT vs ASND — Head-to-Head

Bigger by revenue
ACT
ACT
1.2× larger
ACT
$312.7M
$267.3M
ASND
Growing faster (revenue YoY)
ASND
ASND
+38.7% gap
ASND
42.3%
3.6%
ACT
Faster 2-yr revenue CAGR
ASND
ASND
Annualised
ASND
60.7%
3.6%
ACT

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
ACT
ACT
ASND
ASND
Revenue
$312.7M
$267.3M
Net Profit
Gross Margin
90.5%
Operating Margin
71.3%
Net Margin
Revenue YoY
3.6%
42.3%
Net Profit YoY
EPS (diluted)
$1.23

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ACT
ACT
ASND
ASND
Q4 25
$312.7M
$267.3M
Q3 25
$311.5M
$230.7M
Q2 25
$304.9M
$170.7M
Q1 25
$306.8M
$109.0M
Q4 24
$301.8M
$187.8M
Q3 24
$309.6M
$62.5M
Q2 24
$298.8M
$38.9M
Q1 24
$291.6M
$103.6M
Net Profit
ACT
ACT
ASND
ASND
Q4 25
Q3 25
$-65.9M
Q2 25
$-42.0M
Q1 25
$-102.2M
Q4 24
Q3 24
$-107.1M
Q2 24
$-118.1M
Q1 24
$-141.5M
Gross Margin
ACT
ACT
ASND
ASND
Q4 25
90.5%
Q3 25
89.5%
Q2 25
80.1%
Q1 25
82.6%
Q4 24
91.9%
Q3 24
80.6%
Q2 24
68.2%
Q1 24
92.1%
Operating Margin
ACT
ACT
ASND
ASND
Q4 25
71.3%
Q3 25
67.4%
5.1%
Q2 25
70.4%
-33.5%
Q1 25
68.9%
-103.2%
Q4 24
68.9%
Q3 24
74.1%
-167.3%
Q2 24
78.6%
-370.2%
Q1 24
70.6%
-51.2%
Net Margin
ACT
ACT
ASND
ASND
Q4 25
Q3 25
-28.5%
Q2 25
-24.6%
Q1 25
-93.7%
Q4 24
Q3 24
-171.5%
Q2 24
-303.9%
Q1 24
-136.6%
EPS (diluted)
ACT
ACT
ASND
ASND
Q4 25
$1.23
Q3 25
$1.10
Q2 25
$1.11
Q1 25
$1.08
Q4 24
$1.05
Q3 24
$1.15
Q2 24
$1.16
Q1 24
$1.01

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ACT
ACT
ASND
ASND
Cash + ST InvestmentsLiquidity on hand
$582.5M
$665.3M
Total DebtLower is stronger
$744.5M
Stockholders' EquityBook value
$5.4B
$-175.8M
Total Assets
$6.9B
$1.4B
Debt / EquityLower = less leverage
0.14×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ACT
ACT
ASND
ASND
Q4 25
$582.5M
$665.3M
Q3 25
$545.6M
$582.2M
Q2 25
$616.0M
$533.6M
Q1 25
$639.0M
$559.4M
Q4 24
$602.8M
$604.3M
Q3 24
$674.9M
$675.6M
Q2 24
$711.3M
$279.4M
Q1 24
$624.3M
$345.9M
Total Debt
ACT
ACT
ASND
ASND
Q4 25
$744.5M
Q3 25
$744.1M
Q2 25
$743.8M
Q1 25
$743.4M
Q4 24
$743.0M
Q3 24
$742.7M
Q2 24
$742.4M
Q1 24
$746.1M
Stockholders' Equity
ACT
ACT
ASND
ASND
Q4 25
$5.4B
$-175.8M
Q3 25
$5.3B
$-188.0M
Q2 25
$5.2B
$-202.6M
Q1 25
$5.1B
$-205.0M
Q4 24
$5.0B
$-114.2M
Q3 24
$5.0B
$-105.1M
Q2 24
$4.8B
$-346.8M
Q1 24
$4.7B
$-257.2M
Total Assets
ACT
ACT
ASND
ASND
Q4 25
$6.9B
$1.4B
Q3 25
$6.9B
$1.2B
Q2 25
$6.8B
$1.2B
Q1 25
$6.7B
$1.1B
Q4 24
$6.5B
$1.3B
Q3 24
$6.6B
$1.2B
Q2 24
$6.3B
$819.0M
Q1 24
$6.3B
$866.7M
Debt / Equity
ACT
ACT
ASND
ASND
Q4 25
0.14×
Q3 25
0.14×
Q2 25
0.14×
Q1 25
0.15×
Q4 24
0.15×
Q3 24
0.15×
Q2 24
0.15×
Q1 24
0.16×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ACT
ACT
ASND
ASND
Operating Cash FlowLast quarter
$724.5M
$58.2M
Free Cash FlowOCF − Capex
FCF MarginFCF / Revenue
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ACT
ACT
ASND
ASND
Q4 25
$724.5M
$58.2M
Q3 25
$192.0M
Q2 25
$119.5M
Q1 25
$226.7M
$-15.5M
Q4 24
$686.3M
$-330.7M
Q3 24
$188.1M
Q2 24
$144.7M
Q1 24
$187.3M
$-109.7M

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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