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Side-by-side financial comparison of AGENUS INC (AGEN) and Amgen (AMGN). Click either name above to swap in a different company.
Amgen is the larger business by last-quarter revenue ($9.9B vs $34.2M, roughly 288.4× AGENUS INC). Amgen runs the higher net margin — 13.5% vs -31.0%, a 44.5% gap on every dollar of revenue. On growth, AGENUS INC posted the faster year-over-year revenue change (27.5% vs 8.6%). Over the past eight quarters, Amgen's revenue compounded faster (15.1% CAGR vs 10.5%).
Agenus Inc. is a Lexington, Massachusetts-based biotechnology company focused on immunotherapy including immuno-oncology, a field that uses the immune system to control or cure cancer. The company is developing checkpoint modulators (CPMs), patient-specific anti-cancer vaccines, and adjuvants designed for use with various vaccines. CPM development is a particularly fast-moving field, since early products have produced unprecedented clinical benefits for patients.
Amgen Inc. is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. The company is ranked 18th on the list of largest biomedical companies by revenue. The name "AMGen" is a portmanteau of the company's original name, Applied Molecular Genetics.
AGEN vs AMGN — Head-to-Head
Income Statement — Q4 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $34.2M | $9.9B |
| Net Profit | $-10.6M | $1.3B |
| Gross Margin | — | 69.8% |
| Operating Margin | 42.1% | 27.6% |
| Net Margin | -31.0% | 13.5% |
| Revenue YoY | 27.5% | 8.6% |
| Net Profit YoY | 77.3% | 112.6% |
| EPS (diluted) | $0.09 | $2.45 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $34.2M | $9.9B | ||
| Q3 25 | $30.2M | $9.6B | ||
| Q2 25 | $25.7M | $9.2B | ||
| Q1 25 | $24.1M | $8.1B | ||
| Q4 24 | $26.8M | $9.1B | ||
| Q3 24 | $25.1M | $8.5B | ||
| Q2 24 | $23.5M | $8.4B | ||
| Q1 24 | $28.0M | $7.4B |
| Q4 25 | $-10.6M | $1.3B | ||
| Q3 25 | $63.9M | $3.2B | ||
| Q2 25 | $-30.0M | $1.4B | ||
| Q1 25 | $-26.4M | $1.7B | ||
| Q4 24 | $-46.8M | $627.0M | ||
| Q3 24 | $-67.2M | $2.8B | ||
| Q2 24 | $-54.8M | $746.0M | ||
| Q1 24 | $-63.5M | $-113.0M |
| Q4 25 | — | 69.8% | ||
| Q3 25 | 97.9% | 67.8% | ||
| Q2 25 | 99.1% | 67.2% | ||
| Q1 25 | 99.4% | 63.6% | ||
| Q4 24 | 99.6% | 65.7% | ||
| Q3 24 | 99.4% | 61.1% | ||
| Q2 24 | 99.5% | 61.4% | ||
| Q1 24 | 99.6% | 57.0% |
| Q4 25 | 42.1% | 27.6% | ||
| Q3 25 | -15.0% | 26.4% | ||
| Q2 25 | -65.0% | 28.9% | ||
| Q1 25 | -55.3% | 14.5% | ||
| Q4 24 | -96.5% | 25.4% | ||
| Q3 24 | -125.5% | 24.1% | ||
| Q2 24 | -128.4% | 22.8% | ||
| Q1 24 | -117.4% | 13.3% |
| Q4 25 | -31.0% | 13.5% | ||
| Q3 25 | 211.4% | 33.7% | ||
| Q2 25 | -116.8% | 15.6% | ||
| Q1 25 | -109.6% | 21.2% | ||
| Q4 24 | -174.4% | 6.9% | ||
| Q3 24 | -267.7% | 33.3% | ||
| Q2 24 | -233.1% | 8.9% | ||
| Q1 24 | -226.6% | -1.5% |
| Q4 25 | $0.09 | $2.45 | ||
| Q3 25 | $1.94 | $5.93 | ||
| Q2 25 | $-1.00 | $2.65 | ||
| Q1 25 | $-1.03 | $3.20 | ||
| Q4 24 | $-1.95 | $1.17 | ||
| Q3 24 | $-3.08 | $5.22 | ||
| Q2 24 | $-2.52 | $1.38 | ||
| Q1 24 | $-3.04 | $-0.21 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $3.0M | $9.1B |
| Total DebtLower is stronger | $44.7M | $54.6B |
| Stockholders' EquityBook value | $-271.1M | $8.7B |
| Total Assets | $226.8M | $90.6B |
| Debt / EquityLower = less leverage | — | 6.31× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $3.0M | $9.1B | ||
| Q3 25 | $3.5M | $9.4B | ||
| Q2 25 | $9.5M | $8.0B | ||
| Q1 25 | $18.5M | $8.8B | ||
| Q4 24 | $40.4M | $12.0B | ||
| Q3 24 | $44.8M | $9.0B | ||
| Q2 24 | $93.7M | $9.3B | ||
| Q1 24 | $52.9M | $9.7B |
| Q4 25 | $44.7M | $54.6B | ||
| Q3 25 | $34.2M | $54.6B | ||
| Q2 25 | $33.9M | $56.2B | ||
| Q1 25 | $33.6M | $57.4B | ||
| Q4 24 | $33.2M | $60.1B | ||
| Q3 24 | — | $60.4B | ||
| Q2 24 | — | $62.6B | ||
| Q1 24 | — | $64.0B |
| Q4 25 | $-271.1M | $8.7B | ||
| Q3 25 | $-274.1M | $9.6B | ||
| Q2 25 | $-354.6M | $7.4B | ||
| Q1 25 | $-341.8M | $6.2B | ||
| Q4 24 | $-326.4M | $5.9B | ||
| Q3 24 | $-292.3M | $7.5B | ||
| Q2 24 | $-241.3M | $5.9B | ||
| Q1 24 | $-201.4M | $5.0B |
| Q4 25 | $226.8M | $90.6B | ||
| Q3 25 | $233.9M | $90.1B | ||
| Q2 25 | $185.2M | $87.9B | ||
| Q1 25 | $200.2M | $89.4B | ||
| Q4 24 | $226.3M | $91.8B | ||
| Q3 24 | $238.5M | $90.9B | ||
| Q2 24 | $292.4M | $90.9B | ||
| Q1 24 | $256.6M | $93.0B |
| Q4 25 | — | 6.31× | ||
| Q3 25 | — | 5.67× | ||
| Q2 25 | — | 7.57× | ||
| Q1 25 | — | 9.24× | ||
| Q4 24 | — | 10.23× | ||
| Q3 24 | — | 8.02× | ||
| Q2 24 | — | 10.57× | ||
| Q1 24 | — | 12.75× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-16.6M | $1.6B |
| Free Cash FlowOCF − Capex | — | $961.0M |
| FCF MarginFCF / Revenue | — | 9.7% |
| Capex IntensityCapex / Revenue | 0.0% | 6.5% |
| Cash ConversionOCF / Net Profit | — | 1.20× |
| TTM Free Cash FlowTrailing 4 quarters | — | $8.1B |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-16.6M | $1.6B | ||
| Q3 25 | $-14.7M | $4.7B | ||
| Q2 25 | $-20.2M | $2.3B | ||
| Q1 25 | $-25.6M | $1.4B | ||
| Q4 24 | $-28.7M | $4.8B | ||
| Q3 24 | $-53.3M | $3.6B | ||
| Q2 24 | $-38.2M | $2.5B | ||
| Q1 24 | $-38.2M | $689.0M |
| Q4 25 | — | $961.0M | ||
| Q3 25 | — | $4.2B | ||
| Q2 25 | $-20.2M | $1.9B | ||
| Q1 25 | $-25.6M | $980.0M | ||
| Q4 24 | $-28.7M | $4.4B | ||
| Q3 24 | $-53.3M | $3.3B | ||
| Q2 24 | $-38.6M | $2.2B | ||
| Q1 24 | $-38.2M | $459.0M |
| Q4 25 | — | 9.7% | ||
| Q3 25 | — | 44.4% | ||
| Q2 25 | -78.7% | 20.8% | ||
| Q1 25 | -106.5% | 12.0% | ||
| Q4 24 | -107.0% | 48.4% | ||
| Q3 24 | -212.2% | 39.0% | ||
| Q2 24 | -164.4% | 26.5% | ||
| Q1 24 | -136.5% | 6.2% |
| Q4 25 | 0.0% | 6.5% | ||
| Q3 25 | 0.0% | 4.6% | ||
| Q2 25 | 0.0% | 4.0% | ||
| Q1 25 | 0.0% | 5.0% | ||
| Q4 24 | 0.3% | 4.1% | ||
| Q3 24 | 0.0% | 3.0% | ||
| Q2 24 | 2.0% | 2.8% | ||
| Q1 24 | 0.1% | 3.1% |
| Q4 25 | — | 1.20× | ||
| Q3 25 | -0.23× | 1.46× | ||
| Q2 25 | — | 1.59× | ||
| Q1 25 | — | 0.80× | ||
| Q4 24 | — | 7.61× | ||
| Q3 24 | — | 1.26× | ||
| Q2 24 | — | 3.30× | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AGEN
Segment breakdown not available.
AMGN
| Products | $9.4B | 95% |
| Xgeva | $291.0M | 3% |
| Vectibix | $163.0M | 2% |
| Aranesp | $115.0M | 1% |
