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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and CF BANKSHARES INC. (CFBK). Click either name above to swap in a different company.
AGIOS PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($20.0M vs $15.7M, roughly 1.3× CF BANKSHARES INC.). CF BANKSHARES INC. runs the higher net margin — 40.0% vs -541.1%, a 581.1% gap on every dollar of revenue. On growth, AGIOS PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (86.1% vs 12.6%). CF BANKSHARES INC. produced more free cash flow last quarter ($18.2M vs $-97.3M). Over the past eight quarters, AGIOS PHARMACEUTICALS, INC.'s revenue compounded faster (56.1% CAGR vs 13.7%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
CF Bankshares Inc. is a U.S.-based regional bank holding company operating through its community bank subsidiary. It offers a full suite of personal and commercial banking solutions including deposit products, various loan options, wealth management services and digital banking tools, primarily serving individual consumers and small-to-medium business clients across the U.S. Midwest region.
AGIO vs CFBK — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $15.7M |
| Net Profit | $-108.0M | $5.7M |
| Gross Margin | 90.6% | — |
| Operating Margin | -608.9% | 43.4% |
| Net Margin | -541.1% | 40.0% |
| Revenue YoY | 86.1% | 12.6% |
| Net Profit YoY | -11.9% | 29.9% |
| EPS (diluted) | $-1.86 | $0.88 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $15.7M | ||
| Q3 25 | $12.9M | $15.5M | ||
| Q2 25 | $12.5M | $15.6M | ||
| Q1 25 | $8.7M | $14.1M | ||
| Q4 24 | $10.7M | $14.0M | ||
| Q3 24 | $9.0M | $13.1M | ||
| Q2 24 | $8.6M | $12.6M | ||
| Q1 24 | $8.2M | $12.2M |
| Q4 25 | $-108.0M | $5.7M | ||
| Q3 25 | $-103.4M | $2.3M | ||
| Q2 25 | $-112.0M | $5.0M | ||
| Q1 25 | $-89.3M | $4.4M | ||
| Q4 24 | $-96.5M | $4.4M | ||
| Q3 24 | $947.9M | $4.2M | ||
| Q2 24 | $-96.1M | $1.7M | ||
| Q1 24 | $-81.5M | $3.1M |
| Q4 25 | 90.6% | — | ||
| Q3 25 | 87.0% | — | ||
| Q2 25 | 86.3% | — | ||
| Q1 25 | 87.6% | — | ||
| Q4 24 | 88.3% | — | ||
| Q3 24 | 91.3% | — | ||
| Q2 24 | 82.6% | — | ||
| Q1 24 | 92.3% | — |
| Q4 25 | -608.9% | 43.4% | ||
| Q3 25 | -907.4% | 17.5% | ||
| Q2 25 | -1020.1% | 41.1% | ||
| Q1 25 | -1222.0% | 39.5% | ||
| Q4 24 | -1165.3% | 36.9% | ||
| Q3 24 | -1146.9% | 40.4% | ||
| Q2 24 | -1228.3% | 15.4% | ||
| Q1 24 | -1124.3% | 30.9% |
| Q4 25 | -541.1% | 40.0% | ||
| Q3 25 | -803.1% | 15.1% | ||
| Q2 25 | -899.4% | 32.3% | ||
| Q1 25 | -1023.3% | 31.4% | ||
| Q4 24 | -899.6% | 35.2% | ||
| Q3 24 | 10574.7% | 32.2% | ||
| Q2 24 | -1115.7% | 13.5% | ||
| Q1 24 | -995.8% | 25.2% |
| Q4 25 | $-1.86 | $0.88 | ||
| Q3 25 | $-1.78 | $0.36 | ||
| Q2 25 | $-1.93 | $0.77 | ||
| Q1 25 | $-1.55 | $0.68 | ||
| Q4 24 | $-1.44 | $0.68 | ||
| Q3 24 | $16.22 | $0.65 | ||
| Q2 24 | $-1.69 | $0.26 | ||
| Q1 24 | $-1.45 | $0.47 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | $259.0M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $184.4M |
| Total Assets | $1.3B | $2.1B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | $259.0M | ||
| Q3 25 | $92.7M | $272.4M | ||
| Q2 25 | $80.9M | $275.7M | ||
| Q1 25 | $79.0M | $241.0M | ||
| Q4 24 | $76.2M | $235.3M | ||
| Q3 24 | $253.7M | $233.5M | ||
| Q2 24 | $84.5M | $241.8M | ||
| Q1 24 | $118.8M | $236.9M |
| Q4 25 | $1.2B | $184.4M | ||
| Q3 25 | $1.3B | $179.3M | ||
| Q2 25 | $1.4B | $177.0M | ||
| Q1 25 | $1.5B | $172.7M | ||
| Q4 24 | $1.5B | $168.4M | ||
| Q3 24 | $1.6B | $164.0M | ||
| Q2 24 | $660.5M | $159.6M | ||
| Q1 24 | $743.9M | $158.0M |
| Q4 25 | $1.3B | $2.1B | ||
| Q3 25 | $1.4B | $2.1B | ||
| Q2 25 | $1.5B | $2.1B | ||
| Q1 25 | $1.6B | $2.1B | ||
| Q4 24 | $1.7B | $2.1B | ||
| Q3 24 | $1.8B | $2.1B | ||
| Q2 24 | $773.1M | $2.0B | ||
| Q1 24 | $849.7M | $2.0B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $18.7M |
| Free Cash FlowOCF − Capex | $-97.3M | $18.2M |
| FCF MarginFCF / Revenue | -487.5% | 115.6% |
| Capex IntensityCapex / Revenue | 5.6% | 3.1% |
| Cash ConversionOCF / Net Profit | — | 3.26× |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | $33.4M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $18.7M | ||
| Q3 25 | $-88.2M | $5.5M | ||
| Q2 25 | $-77.1M | $8.0M | ||
| Q1 25 | $-111.5M | $2.2M | ||
| Q4 24 | $-133.2M | $14.2M | ||
| Q3 24 | $-84.2M | $-1.3M | ||
| Q2 24 | $-72.6M | $4.0M | ||
| Q1 24 | $-99.9M | $-1.2M |
| Q4 25 | $-97.3M | $18.2M | ||
| Q3 25 | $-89.7M | $5.2M | ||
| Q2 25 | $-78.0M | $7.8M | ||
| Q1 25 | $-112.3M | $2.2M | ||
| Q4 24 | $-134.1M | $13.9M | ||
| Q3 24 | $-84.6M | $-1.3M | ||
| Q2 24 | $-72.7M | $4.0M | ||
| Q1 24 | $-100.0M | $-1.2M |
| Q4 25 | -487.5% | 115.6% | ||
| Q3 25 | -696.5% | 33.6% | ||
| Q2 25 | -626.2% | 50.3% | ||
| Q1 25 | -1286.4% | 15.2% | ||
| Q4 24 | -1250.1% | 99.6% | ||
| Q3 24 | -944.2% | -9.9% | ||
| Q2 24 | -844.4% | 31.6% | ||
| Q1 24 | -1221.2% | -9.5% |
| Q4 25 | 5.6% | 3.1% | ||
| Q3 25 | 12.1% | 1.7% | ||
| Q2 25 | 7.0% | 0.7% | ||
| Q1 25 | 8.8% | 0.4% | ||
| Q4 24 | 9.0% | 1.9% | ||
| Q3 24 | 4.7% | 0.2% | ||
| Q2 24 | 1.8% | 0.1% | ||
| Q1 24 | 1.7% | 0.0% |
| Q4 25 | — | 3.26× | ||
| Q3 25 | — | 2.34× | ||
| Q2 25 | — | 1.58× | ||
| Q1 25 | — | 0.50× | ||
| Q4 24 | — | 3.21× | ||
| Q3 24 | -0.09× | -0.30× | ||
| Q2 24 | — | 2.35× | ||
| Q1 24 | — | -0.38× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
