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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and CoastalSouth Bancshares, Inc. (COSO). Click either name above to swap in a different company.

CoastalSouth Bancshares, Inc. is the larger business by last-quarter revenue ($21.3M vs $20.0M, roughly 1.1× AGIOS PHARMACEUTICALS, INC.). CoastalSouth Bancshares, Inc. runs the higher net margin — 31.7% vs -541.1%, a 572.8% gap on every dollar of revenue. CoastalSouth Bancshares, Inc. produced more free cash flow last quarter ($-5.9M vs $-97.3M).

Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.

CoastalSouth Bancshares, Inc. is a U.S.-based regional bank holding company. It provides a full range of personal and commercial banking services including deposit accounts, consumer loans, mortgages, commercial financing and wealth management solutions for retail customers and small-to-medium enterprises across the U.S. Gulf Coast region.

AGIO vs COSO — Head-to-Head

Bigger by revenue
COSO
COSO
1.1× larger
COSO
$21.3M
$20.0M
AGIO
Higher net margin
COSO
COSO
572.8% more per $
COSO
31.7%
-541.1%
AGIO
More free cash flow
COSO
COSO
$91.4M more FCF
COSO
$-5.9M
$-97.3M
AGIO

Income Statement — Q4 FY2025 vs Q3 FY2025

Metric
AGIO
AGIO
COSO
COSO
Revenue
$20.0M
$21.3M
Net Profit
$-108.0M
$6.7M
Gross Margin
90.6%
Operating Margin
-608.9%
41.2%
Net Margin
-541.1%
31.7%
Revenue YoY
86.1%
Net Profit YoY
-11.9%
EPS (diluted)
$-1.86
$0.54

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
AGIO
AGIO
COSO
COSO
Q4 25
$20.0M
Q3 25
$12.9M
$21.3M
Q2 25
$12.5M
$19.9M
Q1 25
$8.7M
Q4 24
$10.7M
Q3 24
$9.0M
Q2 24
$8.6M
Q1 24
$8.2M
Net Profit
AGIO
AGIO
COSO
COSO
Q4 25
$-108.0M
Q3 25
$-103.4M
$6.7M
Q2 25
$-112.0M
$6.0M
Q1 25
$-89.3M
Q4 24
$-96.5M
Q3 24
$947.9M
Q2 24
$-96.1M
Q1 24
$-81.5M
Gross Margin
AGIO
AGIO
COSO
COSO
Q4 25
90.6%
Q3 25
87.0%
Q2 25
86.3%
Q1 25
87.6%
Q4 24
88.3%
Q3 24
91.3%
Q2 24
82.6%
Q1 24
92.3%
Operating Margin
AGIO
AGIO
COSO
COSO
Q4 25
-608.9%
Q3 25
-907.4%
41.2%
Q2 25
-1020.1%
35.4%
Q1 25
-1222.0%
Q4 24
-1165.3%
Q3 24
-1146.9%
Q2 24
-1228.3%
Q1 24
-1124.3%
Net Margin
AGIO
AGIO
COSO
COSO
Q4 25
-541.1%
Q3 25
-803.1%
31.7%
Q2 25
-899.4%
30.0%
Q1 25
-1023.3%
Q4 24
-899.6%
Q3 24
10574.7%
Q2 24
-1115.7%
Q1 24
-995.8%
EPS (diluted)
AGIO
AGIO
COSO
COSO
Q4 25
$-1.86
Q3 25
$-1.78
$0.54
Q2 25
$-1.93
$0.57
Q1 25
$-1.55
Q4 24
$-1.44
Q3 24
$16.22
Q2 24
$-1.69
Q1 24
$-1.45

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
AGIO
AGIO
COSO
COSO
Cash + ST InvestmentsLiquidity on hand
$89.1M
Total DebtLower is stronger
Stockholders' EquityBook value
$1.2B
$250.4M
Total Assets
$1.3B
$2.3B
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
AGIO
AGIO
COSO
COSO
Q4 25
$89.1M
Q3 25
$92.7M
Q2 25
$80.9M
Q1 25
$79.0M
Q4 24
$76.2M
Q3 24
$253.7M
Q2 24
$84.5M
Q1 24
$118.8M
Stockholders' Equity
AGIO
AGIO
COSO
COSO
Q4 25
$1.2B
Q3 25
$1.3B
$250.4M
Q2 25
$1.4B
$209.4M
Q1 25
$1.5B
Q4 24
$1.5B
Q3 24
$1.6B
Q2 24
$660.5M
Q1 24
$743.9M
Total Assets
AGIO
AGIO
COSO
COSO
Q4 25
$1.3B
Q3 25
$1.4B
$2.3B
Q2 25
$1.5B
$2.2B
Q1 25
$1.6B
Q4 24
$1.7B
Q3 24
$1.8B
Q2 24
$773.1M
Q1 24
$849.7M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
AGIO
AGIO
COSO
COSO
Operating Cash FlowLast quarter
$-96.2M
$-5.5M
Free Cash FlowOCF − Capex
$-97.3M
$-5.9M
FCF MarginFCF / Revenue
-487.5%
-27.7%
Capex IntensityCapex / Revenue
5.6%
1.9%
Cash ConversionOCF / Net Profit
-0.82×
TTM Free Cash FlowTrailing 4 quarters
$-377.3M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
AGIO
AGIO
COSO
COSO
Q4 25
$-96.2M
Q3 25
$-88.2M
$-5.5M
Q2 25
$-77.1M
$-16.8M
Q1 25
$-111.5M
Q4 24
$-133.2M
Q3 24
$-84.2M
Q2 24
$-72.6M
Q1 24
$-99.9M
Free Cash Flow
AGIO
AGIO
COSO
COSO
Q4 25
$-97.3M
Q3 25
$-89.7M
$-5.9M
Q2 25
$-78.0M
$-17.9M
Q1 25
$-112.3M
Q4 24
$-134.1M
Q3 24
$-84.6M
Q2 24
$-72.7M
Q1 24
$-100.0M
FCF Margin
AGIO
AGIO
COSO
COSO
Q4 25
-487.5%
Q3 25
-696.5%
-27.7%
Q2 25
-626.2%
-90.3%
Q1 25
-1286.4%
Q4 24
-1250.1%
Q3 24
-944.2%
Q2 24
-844.4%
Q1 24
-1221.2%
Capex Intensity
AGIO
AGIO
COSO
COSO
Q4 25
5.6%
Q3 25
12.1%
1.9%
Q2 25
7.0%
5.5%
Q1 25
8.8%
Q4 24
9.0%
Q3 24
4.7%
Q2 24
1.8%
Q1 24
1.7%
Cash Conversion
AGIO
AGIO
COSO
COSO
Q4 25
Q3 25
-0.82×
Q2 25
-2.82×
Q1 25
Q4 24
Q3 24
-0.09×
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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