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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and Crexendo, Inc. (CXDO). Click either name above to swap in a different company.
AGIOS PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($20.0M vs $18.1M, roughly 1.1× Crexendo, Inc.). Crexendo, Inc. runs the higher net margin — 6.7% vs -541.1%, a 547.8% gap on every dollar of revenue. On growth, AGIOS PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (86.1% vs 11.2%). Over the past eight quarters, AGIOS PHARMACEUTICALS, INC.'s revenue compounded faster (56.1% CAGR vs 12.4%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
Crexendo, Inc. is a U.S.-headquartered cloud communications technology provider. It delivers unified communications as a service (UCaaS), contact center solutions, business VoIP services, and collaborative work tools, primarily catering to small and medium-sized enterprises operating in the North American market.
AGIO vs CXDO — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $18.1M |
| Net Profit | $-108.0M | $1.2M |
| Gross Margin | 90.6% | — |
| Operating Margin | -608.9% | 6.3% |
| Net Margin | -541.1% | 6.7% |
| Revenue YoY | 86.1% | 11.2% |
| Net Profit YoY | -11.9% | 140.2% |
| EPS (diluted) | $-1.86 | $0.03 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $18.1M | ||
| Q3 25 | $12.9M | $17.5M | ||
| Q2 25 | $12.5M | $16.6M | ||
| Q1 25 | $8.7M | $16.1M | ||
| Q4 24 | $10.7M | $16.2M | ||
| Q3 24 | $9.0M | $15.6M | ||
| Q2 24 | $8.6M | $14.7M | ||
| Q1 24 | $8.2M | $14.3M |
| Q4 25 | $-108.0M | $1.2M | ||
| Q3 25 | $-103.4M | $1.4M | ||
| Q2 25 | $-112.0M | $1.2M | ||
| Q1 25 | $-89.3M | $1.2M | ||
| Q4 24 | $-96.5M | $507.0K | ||
| Q3 24 | $947.9M | $148.0K | ||
| Q2 24 | $-96.1M | $588.0K | ||
| Q1 24 | $-81.5M | $434.0K |
| Q4 25 | 90.6% | — | ||
| Q3 25 | 87.0% | — | ||
| Q2 25 | 86.3% | — | ||
| Q1 25 | 87.6% | — | ||
| Q4 24 | 88.3% | — | ||
| Q3 24 | 91.3% | — | ||
| Q2 24 | 82.6% | — | ||
| Q1 24 | 92.3% | — |
| Q4 25 | -608.9% | 6.3% | ||
| Q3 25 | -907.4% | 7.5% | ||
| Q2 25 | -1020.1% | 6.7% | ||
| Q1 25 | -1222.0% | 7.2% | ||
| Q4 24 | -1165.3% | 3.9% | ||
| Q3 24 | -1146.9% | 0.9% | ||
| Q2 24 | -1228.3% | 3.9% | ||
| Q1 24 | -1124.3% | 3.4% |
| Q4 25 | -541.1% | 6.7% | ||
| Q3 25 | -803.1% | 8.3% | ||
| Q2 25 | -899.4% | 7.4% | ||
| Q1 25 | -1023.3% | 7.3% | ||
| Q4 24 | -899.6% | 3.1% | ||
| Q3 24 | 10574.7% | 0.9% | ||
| Q2 24 | -1115.7% | 4.0% | ||
| Q1 24 | -995.8% | 3.0% |
| Q4 25 | $-1.86 | $0.03 | ||
| Q3 25 | $-1.78 | $0.05 | ||
| Q2 25 | $-1.93 | $0.04 | ||
| Q1 25 | $-1.55 | $0.04 | ||
| Q4 24 | $-1.44 | $0.03 | ||
| Q3 24 | $16.22 | $0.00 | ||
| Q2 24 | $-1.69 | $0.02 | ||
| Q1 24 | $-1.45 | $0.01 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | — |
| Total DebtLower is stronger | — | $114.0K |
| Stockholders' EquityBook value | $1.2B | $63.8M |
| Total Assets | $1.3B | $77.7M |
| Debt / EquityLower = less leverage | — | 0.00× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | — | ||
| Q3 25 | $92.7M | — | ||
| Q2 25 | $80.9M | — | ||
| Q1 25 | $79.0M | — | ||
| Q4 24 | $76.2M | — | ||
| Q3 24 | $253.7M | — | ||
| Q2 24 | $84.5M | — | ||
| Q1 24 | $118.8M | — |
| Q4 25 | — | $114.0K | ||
| Q3 25 | — | $236.0K | ||
| Q2 25 | — | $356.0K | ||
| Q1 25 | — | $475.0K | ||
| Q4 24 | — | $592.0K | ||
| Q3 24 | — | $709.0K | ||
| Q2 24 | — | $823.0K | ||
| Q1 24 | — | $937.0K |
| Q4 25 | $1.2B | $63.8M | ||
| Q3 25 | $1.3B | $61.3M | ||
| Q2 25 | $1.4B | $58.3M | ||
| Q1 25 | $1.5B | $55.2M | ||
| Q4 24 | $1.5B | $51.4M | ||
| Q3 24 | $1.6B | $49.5M | ||
| Q2 24 | $660.5M | $48.2M | ||
| Q1 24 | $743.9M | $46.8M |
| Q4 25 | $1.3B | $77.7M | ||
| Q3 25 | $1.4B | $76.0M | ||
| Q2 25 | $1.5B | $71.4M | ||
| Q1 25 | $1.6B | $67.4M | ||
| Q4 24 | $1.7B | $64.9M | ||
| Q3 24 | $1.8B | $62.3M | ||
| Q2 24 | $773.1M | $59.6M | ||
| Q1 24 | $849.7M | $57.5M |
| Q4 25 | — | 0.00× | ||
| Q3 25 | — | 0.00× | ||
| Q2 25 | — | 0.01× | ||
| Q1 25 | — | 0.01× | ||
| Q4 24 | — | 0.01× | ||
| Q3 24 | — | 0.01× | ||
| Q2 24 | — | 0.02× | ||
| Q1 24 | — | 0.02× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $2.3M |
| Free Cash FlowOCF − Capex | $-97.3M | — |
| FCF MarginFCF / Revenue | -487.5% | — |
| Capex IntensityCapex / Revenue | 5.6% | 0.0% |
| Cash ConversionOCF / Net Profit | — | 1.93× |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $2.3M | ||
| Q3 25 | $-88.2M | $4.4M | ||
| Q2 25 | $-77.1M | $1.3M | ||
| Q1 25 | $-111.5M | $1.2M | ||
| Q4 24 | $-133.2M | $2.2M | ||
| Q3 24 | $-84.2M | $1.6M | ||
| Q2 24 | $-72.6M | $2.7M | ||
| Q1 24 | $-99.9M | $-166.0K |
| Q4 25 | $-97.3M | — | ||
| Q3 25 | $-89.7M | — | ||
| Q2 25 | $-78.0M | $1.3M | ||
| Q1 25 | $-112.3M | — | ||
| Q4 24 | $-134.1M | $2.1M | ||
| Q3 24 | $-84.6M | — | ||
| Q2 24 | $-72.7M | — | ||
| Q1 24 | $-100.0M | — |
| Q4 25 | -487.5% | — | ||
| Q3 25 | -696.5% | — | ||
| Q2 25 | -626.2% | 7.7% | ||
| Q1 25 | -1286.4% | — | ||
| Q4 24 | -1250.1% | 13.2% | ||
| Q3 24 | -944.2% | — | ||
| Q2 24 | -844.4% | — | ||
| Q1 24 | -1221.2% | — |
| Q4 25 | 5.6% | 0.0% | ||
| Q3 25 | 12.1% | 0.0% | ||
| Q2 25 | 7.0% | 0.1% | ||
| Q1 25 | 8.8% | 0.0% | ||
| Q4 24 | 9.0% | 0.2% | ||
| Q3 24 | 4.7% | 0.0% | ||
| Q2 24 | 1.8% | 0.0% | ||
| Q1 24 | 1.7% | 0.0% |
| Q4 25 | — | 1.93× | ||
| Q3 25 | — | 3.05× | ||
| Q2 25 | — | 1.05× | ||
| Q1 25 | — | 1.06× | ||
| Q4 24 | — | 4.29× | ||
| Q3 24 | -0.09× | 10.95× | ||
| Q2 24 | — | 4.51× | ||
| Q1 24 | — | -0.38× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AGIO
Segment breakdown not available.
CXDO
| Services | $8.6M | 48% |
| Software Solution Segment | $8.3M | 46% |
| Products | $1.1M | 6% |
