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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and Orchid Island Capital, Inc. (ORC). Click either name above to swap in a different company.
Orchid Island Capital, Inc. is the larger business by last-quarter revenue ($38.5M vs $20.0M, roughly 1.9× AGIOS PHARMACEUTICALS, INC.). Orchid Island Capital, Inc. runs the higher net margin — 268.7% vs -541.1%, a 809.8% gap on every dollar of revenue. On growth, Orchid Island Capital, Inc. posted the faster year-over-year revenue change (372.6% vs 86.1%). Over the past eight quarters, Orchid Island Capital, Inc.'s revenue compounded faster (301.6% CAGR vs 56.1%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
Orchid Island Capital, Inc. is a U.S.-based specialty finance company operating as a real estate investment trust. It primarily invests in residential mortgage-backed securities, including agency and non-agency products, targeting consistent risk-adjusted returns for its investors across U.S. fixed income markets.
AGIO vs ORC — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $38.5M |
| Net Profit | $-108.0M | $103.4M |
| Gross Margin | 90.6% | — |
| Operating Margin | -608.9% | — |
| Net Margin | -541.1% | 268.7% |
| Revenue YoY | 86.1% | 372.6% |
| Net Profit YoY | -11.9% | 1764.9% |
| EPS (diluted) | $-1.86 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $38.5M | ||
| Q3 25 | $12.9M | $26.9M | ||
| Q2 25 | $12.5M | $23.2M | ||
| Q1 25 | $8.7M | $19.7M | ||
| Q4 24 | $10.7M | — | ||
| Q3 24 | $9.0M | $340.0K | ||
| Q2 24 | $8.6M | $-697.0K | ||
| Q1 24 | $8.2M | $-2.5M |
| Q4 25 | $-108.0M | $103.4M | ||
| Q3 25 | $-103.4M | $72.1M | ||
| Q2 25 | $-112.0M | $-33.6M | ||
| Q1 25 | $-89.3M | $17.1M | ||
| Q4 24 | $-96.5M | — | ||
| Q3 24 | $947.9M | $17.3M | ||
| Q2 24 | $-96.1M | $-5.0M | ||
| Q1 24 | $-81.5M | $19.8M |
| Q4 25 | 90.6% | — | ||
| Q3 25 | 87.0% | — | ||
| Q2 25 | 86.3% | — | ||
| Q1 25 | 87.6% | — | ||
| Q4 24 | 88.3% | — | ||
| Q3 24 | 91.3% | — | ||
| Q2 24 | 82.6% | — | ||
| Q1 24 | 92.3% | — |
| Q4 25 | -608.9% | — | ||
| Q3 25 | -907.4% | — | ||
| Q2 25 | -1020.1% | — | ||
| Q1 25 | -1222.0% | — | ||
| Q4 24 | -1165.3% | — | ||
| Q3 24 | -1146.9% | — | ||
| Q2 24 | -1228.3% | — | ||
| Q1 24 | -1124.3% | — |
| Q4 25 | -541.1% | 268.7% | ||
| Q3 25 | -803.1% | 267.8% | ||
| Q2 25 | -899.4% | -145.0% | ||
| Q1 25 | -1023.3% | 86.9% | ||
| Q4 24 | -899.6% | — | ||
| Q3 24 | 10574.7% | 5094.1% | ||
| Q2 24 | -1115.7% | 714.3% | ||
| Q1 24 | -995.8% | -794.2% |
| Q4 25 | $-1.86 | — | ||
| Q3 25 | $-1.78 | — | ||
| Q2 25 | $-1.93 | — | ||
| Q1 25 | $-1.55 | — | ||
| Q4 24 | $-1.44 | — | ||
| Q3 24 | $16.22 | — | ||
| Q2 24 | $-1.69 | — | ||
| Q1 24 | $-1.45 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | $665.9M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $1.4B |
| Total Assets | $1.3B | $11.7B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | $665.9M | ||
| Q3 25 | $92.7M | $583.9M | ||
| Q2 25 | $80.9M | $440.8M | ||
| Q1 25 | $79.0M | $396.4M | ||
| Q4 24 | $76.2M | — | ||
| Q3 24 | $253.7M | $322.1M | ||
| Q2 24 | $84.5M | $241.0M | ||
| Q1 24 | $118.8M | $190.4M |
| Q4 25 | $1.2B | $1.4B | ||
| Q3 25 | $1.3B | $1.1B | ||
| Q2 25 | $1.4B | $912.0M | ||
| Q1 25 | $1.5B | $855.9M | ||
| Q4 24 | $1.5B | — | ||
| Q3 24 | $1.6B | $656.0M | ||
| Q2 24 | $660.5M | $555.9M | ||
| Q1 24 | $743.9M | $481.6M |
| Q4 25 | $1.3B | $11.7B | ||
| Q3 25 | $1.4B | $9.1B | ||
| Q2 25 | $1.5B | $7.6B | ||
| Q1 25 | $1.6B | $7.3B | ||
| Q4 24 | $1.7B | — | ||
| Q3 24 | $1.8B | $5.9B | ||
| Q2 24 | $773.1M | $4.9B | ||
| Q1 24 | $849.7M | $4.2B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $120.4M |
| Free Cash FlowOCF − Capex | $-97.3M | — |
| FCF MarginFCF / Revenue | -487.5% | — |
| Capex IntensityCapex / Revenue | 5.6% | — |
| Cash ConversionOCF / Net Profit | — | 1.16× |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $120.4M | ||
| Q3 25 | $-88.2M | $28.0M | ||
| Q2 25 | $-77.1M | $18.4M | ||
| Q1 25 | $-111.5M | $25.8M | ||
| Q4 24 | $-133.2M | — | ||
| Q3 24 | $-84.2M | $-14.8M | ||
| Q2 24 | $-72.6M | $19.3M | ||
| Q1 24 | $-99.9M | $45.0M |
| Q4 25 | $-97.3M | — | ||
| Q3 25 | $-89.7M | — | ||
| Q2 25 | $-78.0M | — | ||
| Q1 25 | $-112.3M | — | ||
| Q4 24 | $-134.1M | — | ||
| Q3 24 | $-84.6M | — | ||
| Q2 24 | $-72.7M | — | ||
| Q1 24 | $-100.0M | — |
| Q4 25 | -487.5% | — | ||
| Q3 25 | -696.5% | — | ||
| Q2 25 | -626.2% | — | ||
| Q1 25 | -1286.4% | — | ||
| Q4 24 | -1250.1% | — | ||
| Q3 24 | -944.2% | — | ||
| Q2 24 | -844.4% | — | ||
| Q1 24 | -1221.2% | — |
| Q4 25 | 5.6% | — | ||
| Q3 25 | 12.1% | — | ||
| Q2 25 | 7.0% | — | ||
| Q1 25 | 8.8% | — | ||
| Q4 24 | 9.0% | — | ||
| Q3 24 | 4.7% | — | ||
| Q2 24 | 1.8% | — | ||
| Q1 24 | 1.7% | — |
| Q4 25 | — | 1.16× | ||
| Q3 25 | — | 0.39× | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 1.51× | ||
| Q4 24 | — | — | ||
| Q3 24 | -0.09× | -0.86× | ||
| Q2 24 | — | — | ||
| Q1 24 | — | 2.28× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
