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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and Spire Global, Inc. (SPIR). Click either name above to swap in a different company.
AGIOS PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($20.0M vs $15.8M, roughly 1.3× Spire Global, Inc.). Spire Global, Inc. runs the higher net margin — -176.6% vs -541.1%, a 364.5% gap on every dollar of revenue. On growth, AGIOS PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (86.1% vs -26.9%). Spire Global, Inc. produced more free cash flow last quarter ($-16.2M vs $-97.3M). Over the past eight quarters, AGIOS PHARMACEUTICALS, INC.'s revenue compounded faster (56.1% CAGR vs -32.6%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
Spire Global, Inc. is a space-to-cloud data and analytics company that specializes in the tracking of global data sets powered by a large constellation of nanosatellites, such as the tracking of maritime, aviation and weather patterns.
AGIO vs SPIR — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $15.8M |
| Net Profit | $-108.0M | $-28.0M |
| Gross Margin | 90.6% | 40.2% |
| Operating Margin | -608.9% | -164.1% |
| Net Margin | -541.1% | -176.6% |
| Revenue YoY | 86.1% | -26.9% |
| Net Profit YoY | -11.9% | 42.7% |
| EPS (diluted) | $-1.86 | $-0.85 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $15.8M | ||
| Q3 25 | $12.9M | $12.7M | ||
| Q2 25 | $12.5M | $19.2M | ||
| Q1 25 | $8.7M | $23.9M | ||
| Q4 24 | $10.7M | $21.7M | ||
| Q3 24 | $9.0M | $28.6M | ||
| Q2 24 | $8.6M | $25.4M | ||
| Q1 24 | $8.2M | $34.8M |
| Q4 25 | $-108.0M | $-28.0M | ||
| Q3 25 | $-103.4M | $-19.7M | ||
| Q2 25 | $-112.0M | $119.6M | ||
| Q1 25 | $-89.3M | $-20.7M | ||
| Q4 24 | $-96.5M | $-48.8M | ||
| Q3 24 | $947.9M | $-12.5M | ||
| Q2 24 | $-96.1M | $-16.6M | ||
| Q1 24 | $-81.5M | $-25.5M |
| Q4 25 | 90.6% | 40.2% | ||
| Q3 25 | 87.0% | 36.6% | ||
| Q2 25 | 86.3% | 48.9% | ||
| Q1 25 | 87.6% | 36.8% | ||
| Q4 24 | 88.3% | 32.4% | ||
| Q3 24 | 91.3% | 44.5% | ||
| Q2 24 | 82.6% | 43.0% | ||
| Q1 24 | 92.3% | 26.5% |
| Q4 25 | -608.9% | -164.1% | ||
| Q3 25 | -907.4% | -166.1% | ||
| Q2 25 | -1020.1% | -122.7% | ||
| Q1 25 | -1222.0% | -106.5% | ||
| Q4 24 | -1165.3% | -144.1% | ||
| Q3 24 | -1146.9% | -48.0% | ||
| Q2 24 | -1228.3% | -48.6% | ||
| Q1 24 | -1124.3% | -34.4% |
| Q4 25 | -541.1% | -176.6% | ||
| Q3 25 | -803.1% | -155.3% | ||
| Q2 25 | -899.4% | 623.4% | ||
| Q1 25 | -1023.3% | -86.5% | ||
| Q4 24 | -899.6% | -225.2% | ||
| Q3 24 | 10574.7% | -43.7% | ||
| Q2 24 | -1115.7% | -65.2% | ||
| Q1 24 | -995.8% | -73.3% |
| Q4 25 | $-1.86 | $-0.85 | ||
| Q3 25 | $-1.78 | $-0.61 | ||
| Q2 25 | $-1.93 | $3.72 | ||
| Q1 25 | $-1.55 | $-0.77 | ||
| Q4 24 | $-1.44 | $-1.93 | ||
| Q3 24 | $16.22 | $-0.50 | ||
| Q2 24 | $-1.69 | $-0.68 | ||
| Q1 24 | $-1.45 | $-1.17 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | $81.8M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $112.9M |
| Total Assets | $1.3B | $211.0M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | $81.8M | ||
| Q3 25 | $92.7M | $96.8M | ||
| Q2 25 | $80.9M | $117.6M | ||
| Q1 25 | $79.0M | $35.9M | ||
| Q4 24 | $76.2M | $19.2M | ||
| Q3 24 | $253.7M | $36.6M | ||
| Q2 24 | $84.5M | $45.8M | ||
| Q1 24 | $118.8M | $63.7M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | $103.7M | ||
| Q4 24 | — | $103.1M | ||
| Q3 24 | — | $4.9M | ||
| Q2 24 | — | $4.9M | ||
| Q1 24 | — | $123.1M |
| Q4 25 | $1.2B | $112.9M | ||
| Q3 25 | $1.3B | $133.1M | ||
| Q2 25 | $1.4B | $149.2M | ||
| Q1 25 | $1.5B | $3.7M | ||
| Q4 24 | $1.5B | $-11.7M | ||
| Q3 24 | $1.6B | $30.8M | ||
| Q2 24 | $660.5M | $40.3M | ||
| Q1 24 | $743.9M | $52.5M |
| Q4 25 | $1.3B | $211.0M | ||
| Q3 25 | $1.4B | $224.3M | ||
| Q2 25 | $1.5B | $239.5M | ||
| Q1 25 | $1.6B | $208.8M | ||
| Q4 24 | $1.7B | $193.6M | ||
| Q3 24 | $1.8B | $224.2M | ||
| Q2 24 | $773.1M | $230.8M | ||
| Q1 24 | $849.7M | $252.3M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 27.92× | ||
| Q4 24 | — | — | ||
| Q3 24 | — | 0.16× | ||
| Q2 24 | — | 0.12× | ||
| Q1 24 | — | 2.35× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $-4.3M |
| Free Cash FlowOCF − Capex | $-97.3M | $-16.2M |
| FCF MarginFCF / Revenue | -487.5% | -102.1% |
| Capex IntensityCapex / Revenue | 5.6% | 75.1% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | $-92.6M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $-4.3M | ||
| Q3 25 | $-88.2M | $-12.0M | ||
| Q2 25 | $-77.1M | $-35.1M | ||
| Q1 25 | $-111.5M | $-8.4M | ||
| Q4 24 | $-133.2M | $-19.2M | ||
| Q3 24 | $-84.2M | $14.0M | ||
| Q2 24 | $-72.6M | $-4.4M | ||
| Q1 24 | $-99.9M | $-8.8M |
| Q4 25 | $-97.3M | $-16.2M | ||
| Q3 25 | $-89.7M | $-20.4M | ||
| Q2 25 | $-78.0M | $-38.7M | ||
| Q1 25 | $-112.3M | $-17.3M | ||
| Q4 24 | $-134.1M | $-24.3M | ||
| Q3 24 | $-84.6M | $5.1M | ||
| Q2 24 | $-72.7M | $-9.9M | ||
| Q1 24 | $-100.0M | $-15.9M |
| Q4 25 | -487.5% | -102.1% | ||
| Q3 25 | -696.5% | -161.3% | ||
| Q2 25 | -626.2% | -201.7% | ||
| Q1 25 | -1286.4% | -72.6% | ||
| Q4 24 | -1250.1% | -112.2% | ||
| Q3 24 | -944.2% | 17.8% | ||
| Q2 24 | -844.4% | -39.0% | ||
| Q1 24 | -1221.2% | -45.7% |
| Q4 25 | 5.6% | 75.1% | ||
| Q3 25 | 12.1% | 66.2% | ||
| Q2 25 | 7.0% | 18.8% | ||
| Q1 25 | 8.8% | 37.3% | ||
| Q4 24 | 9.0% | 23.5% | ||
| Q3 24 | 4.7% | 31.2% | ||
| Q2 24 | 1.8% | 21.8% | ||
| Q1 24 | 1.7% | 20.3% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | -0.29× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | -0.09× | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
