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Side-by-side financial comparison of Alkermes plc. (ALKS) and CULLEN/FROST BANKERS, INC. (CFR). Click either name above to swap in a different company.
CULLEN/FROST BANKERS, INC. is the larger business by last-quarter revenue ($580.9M vs $384.5M, roughly 1.5× Alkermes plc.). CULLEN/FROST BANKERS, INC. runs the higher net margin — 28.6% vs 12.8%, a 15.8% gap on every dollar of revenue. On growth, CULLEN/FROST BANKERS, INC. posted the faster year-over-year revenue change (8.3% vs -10.6%). Alkermes plc. produced more free cash flow last quarter ($170.0M vs $127.3M). Over the past eight quarters, CULLEN/FROST BANKERS, INC.'s revenue compounded faster (7.6% CAGR vs 4.8%).
Alkermes plc is a fully-integrated biopharmaceutical company that focuses on developing medicines for psychiatric and neurological disorders. The company was founded in 1987 by Michael Wall. In September 2011 Alkermes, Inc. merged with Elan Drug Technologies (EDT), the former drug formulation and manufacturing division of Élan Corporation, plc. The company is headquartered in Dublin, and has an R&D center in Waltham, Massachusetts, and a manufacturing facility in Wilmington, Ohio.
Frost Bank is an American bank based in San Antonio that is chartered in Texas, with 200 branches and 1,750 automated teller machines in the state. It is the primary subsidiary of Cullen/Frost Bankers, Inc., a bank holding company. It is one of the 60 largest banks of the country by total assets.
ALKS vs CFR — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $384.5M | $580.9M |
| Net Profit | $49.3M | $166.3M |
| Gross Margin | 88.0% | — |
| Operating Margin | 15.1% | 34.1% |
| Net Margin | 12.8% | 28.6% |
| Revenue YoY | -10.6% | 8.3% |
| Net Profit YoY | -66.3% | 7.4% |
| EPS (diluted) | $0.29 | $2.56 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $384.5M | $580.9M | ||
| Q3 25 | $394.2M | $567.3M | ||
| Q2 25 | $390.7M | $546.9M | ||
| Q1 25 | $306.5M | $540.2M | ||
| Q4 24 | $430.0M | $536.3M | ||
| Q3 24 | $378.1M | $518.0M | ||
| Q2 24 | $399.1M | $507.9M | ||
| Q1 24 | $350.4M | $501.4M |
| Q4 25 | $49.3M | $166.3M | ||
| Q3 25 | $82.8M | $174.4M | ||
| Q2 25 | $87.1M | $157.0M | ||
| Q1 25 | $22.5M | $150.9M | ||
| Q4 24 | $146.5M | $154.9M | ||
| Q3 24 | $92.4M | $146.5M | ||
| Q2 24 | $91.4M | $145.5M | ||
| Q1 24 | $36.8M | $135.7M |
| Q4 25 | 88.0% | — | ||
| Q3 25 | 86.9% | — | ||
| Q2 25 | 87.3% | — | ||
| Q1 25 | 83.9% | — | ||
| Q4 24 | 85.6% | — | ||
| Q3 24 | 83.3% | — | ||
| Q2 24 | 84.6% | — | ||
| Q1 24 | 83.3% | — |
| Q4 25 | 15.1% | 34.1% | ||
| Q3 25 | 22.6% | 36.7% | ||
| Q2 25 | 23.8% | 34.1% | ||
| Q1 25 | 4.5% | 33.2% | ||
| Q4 24 | 37.8% | 34.3% | ||
| Q3 24 | 27.7% | 33.8% | ||
| Q2 24 | 27.5% | 34.5% | ||
| Q1 24 | 12.4% | 32.2% |
| Q4 25 | 12.8% | 28.6% | ||
| Q3 25 | 21.0% | 30.7% | ||
| Q2 25 | 22.3% | 28.7% | ||
| Q1 25 | 7.3% | 27.9% | ||
| Q4 24 | 34.1% | 28.9% | ||
| Q3 24 | 24.4% | 28.3% | ||
| Q2 24 | 22.9% | 28.6% | ||
| Q1 24 | 10.5% | 27.1% |
| Q4 25 | $0.29 | $2.56 | ||
| Q3 25 | $0.49 | $2.67 | ||
| Q2 25 | $0.52 | $2.39 | ||
| Q1 25 | $0.13 | $2.30 | ||
| Q4 24 | $0.88 | $2.36 | ||
| Q3 24 | $0.55 | $2.24 | ||
| Q2 24 | $0.53 | $2.21 | ||
| Q1 24 | $0.21 | $2.06 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $388.6M | — |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.8B | $4.6B |
| Total Assets | $2.5B | $53.0B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $388.6M | — | ||
| Q3 25 | $616.4M | — | ||
| Q2 25 | $521.2M | — | ||
| Q1 25 | $399.8M | — | ||
| Q4 24 | $291.1M | — | ||
| Q3 24 | $396.3M | — | ||
| Q2 24 | $535.1M | — | ||
| Q1 24 | $420.8M | — |
| Q4 25 | $1.8B | $4.6B | ||
| Q3 25 | $1.7B | $4.5B | ||
| Q2 25 | $1.6B | $4.2B | ||
| Q1 25 | $1.5B | $4.1B | ||
| Q4 24 | $1.5B | $3.9B | ||
| Q3 24 | $1.3B | $4.1B | ||
| Q2 24 | $1.3B | $3.7B | ||
| Q1 24 | $1.3B | $3.6B |
| Q4 25 | $2.5B | $53.0B | ||
| Q3 25 | $2.3B | $52.5B | ||
| Q2 25 | $2.3B | $51.4B | ||
| Q1 25 | $2.1B | $52.0B | ||
| Q4 24 | $2.1B | $52.5B | ||
| Q3 24 | $2.2B | $51.0B | ||
| Q2 24 | $2.2B | $48.8B | ||
| Q1 24 | $2.1B | $49.5B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $170.1M | $274.0M |
| Free Cash FlowOCF − Capex | $170.0M | $127.3M |
| FCF MarginFCF / Revenue | 44.2% | 21.9% |
| Capex IntensityCapex / Revenue | 0.0% | 25.2% |
| Cash ConversionOCF / Net Profit | 3.45× | 1.65× |
| TTM Free Cash FlowTrailing 4 quarters | $480.3M | $116.4M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $170.1M | $274.0M | ||
| Q3 25 | $101.7M | $248.6M | ||
| Q2 25 | $150.2M | $140.8M | ||
| Q1 25 | $98.8M | $-296.1M | ||
| Q4 24 | $190.4M | $989.5M | ||
| Q3 24 | $81.6M | $307.2M | ||
| Q2 24 | $146.0M | $129.6M | ||
| Q1 24 | $21.1M | $488.4M |
| Q4 25 | $170.0M | $127.3M | ||
| Q3 25 | $84.4M | $211.7M | ||
| Q2 25 | $137.2M | $114.5M | ||
| Q1 25 | $88.7M | $-337.1M | ||
| Q4 24 | $180.6M | $861.8M | ||
| Q3 24 | $73.3M | $281.9M | ||
| Q2 24 | $138.9M | $103.0M | ||
| Q1 24 | $12.8M | $450.3M |
| Q4 25 | 44.2% | 21.9% | ||
| Q3 25 | 21.4% | 37.3% | ||
| Q2 25 | 35.1% | 20.9% | ||
| Q1 25 | 28.9% | -62.4% | ||
| Q4 24 | 42.0% | 160.7% | ||
| Q3 24 | 19.4% | 54.4% | ||
| Q2 24 | 34.8% | 20.3% | ||
| Q1 24 | 3.6% | 89.8% |
| Q4 25 | 0.0% | 25.2% | ||
| Q3 25 | 4.4% | 6.5% | ||
| Q2 25 | 3.3% | 4.8% | ||
| Q1 25 | 3.3% | 7.6% | ||
| Q4 24 | 2.3% | 23.8% | ||
| Q3 24 | 2.2% | 4.9% | ||
| Q2 24 | 1.8% | 5.2% | ||
| Q1 24 | 2.4% | 7.6% |
| Q4 25 | 3.45× | 1.65× | ||
| Q3 25 | 1.23× | 1.43× | ||
| Q2 25 | 1.72× | 0.90× | ||
| Q1 25 | 4.40× | -1.96× | ||
| Q4 24 | 1.30× | 6.39× | ||
| Q3 24 | 0.88× | 2.10× | ||
| Q2 24 | 1.60× | 0.89× | ||
| Q1 24 | 0.57× | 3.60× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ALKS
| Vivitrol | $124.1M | 32% |
| Aristada And Aristada Initio | $97.2M | 25% |
| LYBALVI | $94.1M | 24% |
| Royalty | $65.7M | 17% |
| Manufacturing Revenue | $3.3M | 1% |
CFR
Segment breakdown not available.
