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Side-by-side financial comparison of Apellis Pharmaceuticals, Inc. (APLS) and PROASSURANCE CORP (PRA). Click either name above to swap in a different company.

PROASSURANCE CORP is the larger business by last-quarter revenue ($269.6M vs $199.9M, roughly 1.3× Apellis Pharmaceuticals, Inc.). PROASSURANCE CORP runs the higher net margin — 12.4% vs -29.5%, a 41.9% gap on every dollar of revenue. On growth, Apellis Pharmaceuticals, Inc. posted the faster year-over-year revenue change (-5.9% vs -7.1%). Over the past eight quarters, Apellis Pharmaceuticals, Inc.'s revenue compounded faster (7.7% CAGR vs -2.7%).

Apellis Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing targeted therapies that modulate the complement system to address serious unmet medical needs. Its core products target ophthalmic conditions like geographic atrophy secondary to age-related macular degeneration, as well as rare hematological and autoimmune disorders, with primary operations in the United States and European markets.

ProAssurance Corporation, headquartered in Birmingham, Alabama, is a property and casualty company that sells professional liability insurance to doctors. The company was founded in 1976 as Mutual Assurance and was later renamed to Medical Assurance in 1997. The name "ProAssurance" was created in 2001 when Medical Assurance merged with Professionals Group. The company is currently the fourth largest medical professional liability insurance writer and has over $6 billion in assets.

APLS vs PRA — Head-to-Head

Bigger by revenue
PRA
PRA
1.3× larger
PRA
$269.6M
$199.9M
APLS
Growing faster (revenue YoY)
APLS
APLS
+1.1% gap
APLS
-5.9%
-7.1%
PRA
Higher net margin
PRA
PRA
41.9% more per $
PRA
12.4%
-29.5%
APLS
Faster 2-yr revenue CAGR
APLS
APLS
Annualised
APLS
7.7%
-2.7%
PRA

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
APLS
APLS
PRA
PRA
Revenue
$199.9M
$269.6M
Net Profit
$-59.0M
$33.4M
Gross Margin
Operating Margin
-25.6%
17.3%
Net Margin
-29.5%
12.4%
Revenue YoY
-5.9%
-7.1%
Net Profit YoY
-62.2%
106.4%
EPS (diluted)
$-0.40
$0.65

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
APLS
APLS
PRA
PRA
Q4 25
$199.9M
$269.6M
Q3 25
$458.6M
$279.6M
Q2 25
$178.5M
$276.8M
Q1 25
$166.8M
$272.1M
Q4 24
$212.5M
$290.1M
Q3 24
$196.8M
$285.3M
Q2 24
$199.7M
$290.4M
Q1 24
$172.3M
$284.7M
Net Profit
APLS
APLS
PRA
PRA
Q4 25
$-59.0M
$33.4M
Q3 25
$215.7M
$1.4M
Q2 25
$-42.2M
$21.9M
Q1 25
$-92.2M
$-5.8M
Q4 24
$-36.4M
$16.2M
Q3 24
$-57.4M
$16.4M
Q2 24
$-37.7M
$15.5M
Q1 24
$-66.4M
$4.6M
Operating Margin
APLS
APLS
PRA
PRA
Q4 25
-25.6%
17.3%
Q3 25
48.7%
1.6%
Q2 25
-18.6%
9.9%
Q1 25
-50.0%
-2.3%
Q4 24
-12.3%
6.5%
Q3 24
-24.0%
7.4%
Q2 24
-14.7%
6.2%
Q1 24
-36.0%
1.9%
Net Margin
APLS
APLS
PRA
PRA
Q4 25
-29.5%
12.4%
Q3 25
47.0%
0.5%
Q2 25
-23.6%
7.9%
Q1 25
-55.3%
-2.1%
Q4 24
-17.1%
5.6%
Q3 24
-29.2%
5.8%
Q2 24
-18.9%
5.3%
Q1 24
-38.5%
1.6%
EPS (diluted)
APLS
APLS
PRA
PRA
Q4 25
$-0.40
$0.65
Q3 25
$1.67
$0.03
Q2 25
$-0.33
$0.42
Q1 25
$-0.74
$-0.11
Q4 24
$-0.30
$0.32
Q3 24
$-0.46
$0.32
Q2 24
$-0.30
$0.30
Q1 24
$-0.54
$0.09

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
APLS
APLS
PRA
PRA
Cash + ST InvestmentsLiquidity on hand
$466.2M
$36.5M
Total DebtLower is stronger
$420.4M
Stockholders' EquityBook value
$370.1M
$1.3B
Total Assets
$1.1B
$5.4B
Debt / EquityLower = less leverage
0.31×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
APLS
APLS
PRA
PRA
Q4 25
$466.2M
$36.5M
Q3 25
$479.2M
$54.5M
Q2 25
$370.0M
$41.6M
Q1 25
$358.4M
$43.5M
Q4 24
$411.3M
$54.9M
Q3 24
$396.9M
$45.3M
Q2 24
$360.1M
$36.9M
Q1 24
$325.9M
$65.4M
Total Debt
APLS
APLS
PRA
PRA
Q4 25
$420.4M
Q3 25
$421.5M
Q2 25
$422.6M
Q1 25
$423.7M
Q4 24
$424.9M
Q3 24
$425.9M
Q2 24
$426.9M
Q1 24
$93.1M
$427.8M
Stockholders' Equity
APLS
APLS
PRA
PRA
Q4 25
$370.1M
$1.3B
Q3 25
$401.2M
$1.3B
Q2 25
$156.3M
$1.3B
Q1 25
$164.2M
$1.2B
Q4 24
$228.5M
$1.2B
Q3 24
$237.1M
$1.2B
Q2 24
$264.3M
$1.1B
Q1 24
$266.7M
$1.1B
Total Assets
APLS
APLS
PRA
PRA
Q4 25
$1.1B
$5.4B
Q3 25
$1.1B
$5.6B
Q2 25
$821.4M
$5.5B
Q1 25
$807.3M
$5.5B
Q4 24
$885.1M
$5.6B
Q3 24
$901.9M
$5.7B
Q2 24
$904.5M
$5.6B
Q1 24
$831.9M
$5.7B
Debt / Equity
APLS
APLS
PRA
PRA
Q4 25
0.31×
Q3 25
0.32×
Q2 25
0.33×
Q1 25
0.34×
Q4 24
0.35×
Q3 24
0.35×
Q2 24
0.38×
Q1 24
0.35×
0.38×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
APLS
APLS
PRA
PRA
Operating Cash FlowLast quarter
$-14.2M
$-25.6M
Free Cash FlowOCF − Capex
$-14.3M
FCF MarginFCF / Revenue
-7.1%
Capex IntensityCapex / Revenue
0.1%
Cash ConversionOCF / Net Profit
-0.77×
TTM Free Cash FlowTrailing 4 quarters
$45.0M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
APLS
APLS
PRA
PRA
Q4 25
$-14.2M
$-25.6M
Q3 25
$108.5M
$27.2M
Q2 25
$4.4M
$-28.1M
Q1 25
$-53.4M
$-11.6M
Q4 24
$19.4M
$-10.7M
Q3 24
$34.1M
$14.0M
Q2 24
$-8.3M
$-12.8M
Q1 24
$-133.0M
$-11.6M
Free Cash Flow
APLS
APLS
PRA
PRA
Q4 25
$-14.3M
Q3 25
$108.3M
Q2 25
$4.4M
Q1 25
$-53.4M
Q4 24
$19.3M
Q3 24
Q2 24
$-8.4M
Q1 24
$-133.3M
FCF Margin
APLS
APLS
PRA
PRA
Q4 25
-7.1%
Q3 25
23.6%
Q2 25
2.5%
Q1 25
-32.0%
Q4 24
9.1%
Q3 24
Q2 24
-4.2%
Q1 24
-77.3%
Capex Intensity
APLS
APLS
PRA
PRA
Q4 25
0.1%
Q3 25
0.0%
Q2 25
0.0%
Q1 25
0.0%
Q4 24
0.0%
Q3 24
0.0%
Q2 24
0.0%
Q1 24
0.2%
Cash Conversion
APLS
APLS
PRA
PRA
Q4 25
-0.77×
Q3 25
0.50×
18.81×
Q2 25
-1.28×
Q1 25
Q4 24
-0.66×
Q3 24
0.85×
Q2 24
-0.83×
Q1 24
-2.52×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

APLS
APLS

Syfovre$155.2M78%
Empaveli Pegcetacoplan$35.1M18%
Licensing And Other Revenue$9.6M5%

PRA
PRA

Workers Compensation Insurance Segment$164.4M61%
Other$59.6M22%
Segregated Portfolio Cell Reinsurance$45.7M17%

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