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Side-by-side financial comparison of ARDELYX, INC. (ARDX) and SMARTFINANCIAL INC. (SMBK). Click either name above to swap in a different company.

ARDELYX, INC. is the larger business by last-quarter revenue ($94.5M vs $53.8M, roughly 1.8× SMARTFINANCIAL INC.). SMARTFINANCIAL INC. runs the higher net margin — 25.4% vs -39.8%, a 65.2% gap on every dollar of revenue. Over the past eight quarters, SMARTFINANCIAL INC.'s revenue compounded faster (15.4% CAGR vs 13.6%).

Ardelyx, Inc. is a commercial-stage biopharmaceutical firm developing and commercializing innovative therapies for gastrointestinal, cardiorenal and metabolic diseases with high unmet medical needs. Its lead product is approved in the US for irritable bowel syndrome with constipation, and it holds a robust pipeline of early and late-stage drug candidates.

SmartFinancial Inc. is a U.S.-based bank holding company that operates its wholly owned subsidiary SmartBank. It offers a full range of retail and commercial banking products including deposit accounts, personal and business loans, mortgage services, and wealth management solutions, primarily serving individual customers and small-to-medium enterprises across the Southeastern United States.

ARDX vs SMBK — Head-to-Head

Bigger by revenue
ARDX
ARDX
1.8× larger
ARDX
$94.5M
$53.8M
SMBK
Higher net margin
SMBK
SMBK
65.2% more per $
SMBK
25.4%
-39.8%
ARDX
Faster 2-yr revenue CAGR
SMBK
SMBK
Annualised
SMBK
15.4%
13.6%
ARDX

Income Statement — Q1 FY2026 vs Q1 FY2026

Metric
ARDX
ARDX
SMBK
SMBK
Revenue
$94.5M
$53.8M
Net Profit
$-37.6M
$13.7M
Gross Margin
Operating Margin
Net Margin
-39.8%
25.4%
Revenue YoY
27.5%
Net Profit YoY
21.6%
EPS (diluted)
$-0.15
$0.81

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ARDX
ARDX
SMBK
SMBK
Q1 26
$94.5M
$53.8M
Q4 25
$125.2M
$53.3M
Q3 25
$110.3M
$51.1M
Q2 25
$97.7M
$49.2M
Q1 25
$74.1M
$46.8M
Q4 24
$116.1M
$46.8M
Q3 24
$98.2M
$44.2M
Q2 24
$73.2M
$40.4M
Net Profit
ARDX
ARDX
SMBK
SMBK
Q1 26
$-37.6M
$13.7M
Q4 25
$-407.0K
$13.7M
Q3 25
$-969.0K
$13.7M
Q2 25
$-19.1M
$11.7M
Q1 25
$-41.1M
$11.3M
Q4 24
$4.6M
$9.6M
Q3 24
$-809.0K
$9.1M
Q2 24
$-16.5M
$8.0M
Gross Margin
ARDX
ARDX
SMBK
SMBK
Q1 26
Q4 25
91.3%
Q3 25
96.4%
Q2 25
87.3%
Q1 25
83.4%
Q4 24
84.3%
Q3 24
84.0%
Q2 24
87.1%
Operating Margin
ARDX
ARDX
SMBK
SMBK
Q1 26
Q4 25
4.1%
31.3%
Q3 25
4.2%
33.2%
Q2 25
-14.7%
29.0%
Q1 25
-49.0%
29.0%
Q4 24
7.0%
26.5%
Q3 24
2.3%
24.3%
Q2 24
-18.6%
25.6%
Net Margin
ARDX
ARDX
SMBK
SMBK
Q1 26
-39.8%
25.4%
Q4 25
-0.3%
25.7%
Q3 25
-0.9%
26.8%
Q2 25
-19.5%
23.8%
Q1 25
-55.5%
24.0%
Q4 24
4.0%
20.6%
Q3 24
-0.8%
20.7%
Q2 24
-22.5%
19.8%
EPS (diluted)
ARDX
ARDX
SMBK
SMBK
Q1 26
$-0.15
$0.81
Q4 25
$-0.01
$0.81
Q3 25
$0.00
$0.81
Q2 25
$-0.08
$0.69
Q1 25
$-0.17
$0.67
Q4 24
$0.01
$0.57
Q3 24
$0.00
$0.54
Q2 24
$-0.07
$0.48

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ARDX
ARDX
SMBK
SMBK
Cash + ST InvestmentsLiquidity on hand
$238.1M
$346.1M
Total DebtLower is stronger
$203.5M
Stockholders' EquityBook value
$148.6M
$562.2M
Total Assets
$504.5M
$5.9B
Debt / EquityLower = less leverage
1.37×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ARDX
ARDX
SMBK
SMBK
Q1 26
$238.1M
$346.1M
Q4 25
$68.0M
$464.4M
Q3 25
$42.7M
$557.1M
Q2 25
$90.0M
$365.1M
Q1 25
$30.8M
$423.0M
Q4 24
$64.9M
$387.6M
Q3 24
$47.4M
$192.9M
Q2 24
$41.9M
$342.8M
Total Debt
ARDX
ARDX
SMBK
SMBK
Q1 26
$203.5M
Q4 25
$202.8M
Q3 25
$202.1M
$1.3M
Q2 25
$201.4M
$7.0M
Q1 25
$151.3M
$7.6M
Q4 24
$150.9M
$8.1M
Q3 24
$100.7M
$9.0M
Q2 24
$100.2M
$12.7M
Stockholders' Equity
ARDX
ARDX
SMBK
SMBK
Q1 26
$148.6M
$562.2M
Q4 25
$166.9M
$552.4M
Q3 25
$154.3M
$538.4M
Q2 25
$139.5M
$519.0M
Q1 25
$145.7M
$505.8M
Q4 24
$173.3M
$491.3M
Q3 24
$158.3M
$489.0M
Q2 24
$147.0M
$472.5M
Total Assets
ARDX
ARDX
SMBK
SMBK
Q1 26
$504.5M
$5.9B
Q4 25
$501.6M
$5.9B
Q3 25
$486.2M
$5.8B
Q2 25
$466.8M
$5.5B
Q1 25
$410.2M
$5.4B
Q4 24
$435.8M
$5.3B
Q3 24
$367.9M
$4.9B
Q2 24
$343.5M
$4.9B
Debt / Equity
ARDX
ARDX
SMBK
SMBK
Q1 26
1.37×
Q4 25
1.21×
Q3 25
1.31×
0.00×
Q2 25
1.44×
0.01×
Q1 25
1.04×
0.02×
Q4 24
0.87×
0.02×
Q3 24
0.64×
0.02×
Q2 24
0.68×
0.03×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ARDX
ARDX

IBSRELA$70.1M74%
XPHOZAH$23.3M25%
Non-cash royalty revenue related to the sale of future royalties$695.0K1%
Product supply revenue$354.0K0%

SMBK
SMBK

Net Interest Income$45.9M85%
Noninterest Income$7.9M15%

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