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Side-by-side financial comparison of Assertio Holdings, Inc. (ASRT) and Spero Therapeutics, Inc. (SPRO). Click either name above to swap in a different company.

Assertio Holdings, Inc. is the larger business by last-quarter revenue ($13.5M vs $12.6M, roughly 1.1× Spero Therapeutics, Inc.). On growth, Spero Therapeutics, Inc. posted the faster year-over-year revenue change (24080.8% vs -57.9%). Over the past eight quarters, Spero Therapeutics, Inc.'s revenue compounded faster (847.7% CAGR vs -35.4%).

Assertio Therapeutics, Inc. is an American specialty pharmaceutical company. It mainly markets products for treatment in neurology, pain and diseases of the central nervous system. Depomed was founded in 1995 and is headquartered in Newark, California. It is a publicly traded company on NASDAQ, with several products approved by the United States Food and Drug Administration (FDA). On August 15, 2018, the company announced its name change from Depomed, Inc., to Assertio Therapeutics, Inc. As o...

ASRT vs SPRO — Head-to-Head

Bigger by revenue
ASRT
ASRT
1.1× larger
ASRT
$13.5M
$12.6M
SPRO
Growing faster (revenue YoY)
SPRO
SPRO
+24138.7% gap
SPRO
24080.8%
-57.9%
ASRT
Faster 2-yr revenue CAGR
SPRO
SPRO
Annualised
SPRO
847.7%
-35.4%
ASRT

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
ASRT
ASRT
SPRO
SPRO
Revenue
$13.5M
$12.6M
Net Profit
$31.5M
Gross Margin
Operating Margin
-86.7%
Net Margin
250.7%
Revenue YoY
-57.9%
24080.8%
Net Profit YoY
250.9%
EPS (diluted)
$-4.54
$0.56

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ASRT
ASRT
SPRO
SPRO
Q4 25
$13.5M
$12.6M
Q3 25
$49.5M
$0
Q2 25
$29.2M
$0
Q1 25
$26.5M
$12.0K
Q4 24
$32.2M
$52.0K
Q3 24
$29.2M
$65.0K
Q2 24
$31.1M
$114.0K
Q1 24
$32.4M
$140.0K
Net Profit
ASRT
ASRT
SPRO
SPRO
Q4 25
$31.5M
Q3 25
$11.4M
$-7.4M
Q2 25
$-16.4M
$-1.7M
Q1 25
$-13.5M
$-13.9M
Q4 24
Q3 24
$-2.9M
$-17.1M
Q2 24
$-3.7M
$-17.9M
Q1 24
$-4.5M
$-12.7M
Operating Margin
ASRT
ASRT
SPRO
SPRO
Q4 25
-86.7%
Q3 25
23.2%
Q2 25
-27.5%
Q1 25
-50.0%
-122758.3%
Q4 24
-41.9%
Q3 24
-10.4%
-28604.6%
Q2 24
-11.6%
-16720.2%
Q1 24
-13.4%
-9987.1%
Net Margin
ASRT
ASRT
SPRO
SPRO
Q4 25
250.7%
Q3 25
23.1%
Q2 25
-56.0%
Q1 25
-51.1%
-115550.0%
Q4 24
Q3 24
-10.0%
-26380.0%
Q2 24
-11.8%
-15668.4%
Q1 24
-13.9%
-9049.3%
EPS (diluted)
ASRT
ASRT
SPRO
SPRO
Q4 25
$-4.54
$0.56
Q3 25
$0.11
$-0.13
Q2 25
$-0.17
$-0.03
Q1 25
$-0.14
$-0.25
Q4 24
$-3.28
Q3 24
$-0.03
$-0.32
Q2 24
$-0.04
$-0.33
Q1 24
$-0.05
$-0.24

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ASRT
ASRT
SPRO
SPRO
Cash + ST InvestmentsLiquidity on hand
$63.4M
$40.3M
Total DebtLower is stronger
Stockholders' EquityBook value
$94.0M
$59.0M
Total Assets
$267.0M
$68.9M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ASRT
ASRT
SPRO
SPRO
Q4 25
$63.4M
$40.3M
Q3 25
$93.4M
$48.6M
Q2 25
$98.2M
$31.2M
Q1 25
$87.3M
$48.9M
Q4 24
$100.1M
$52.9M
Q3 24
$88.6M
$76.3M
Q2 24
$88.4M
$63.5M
Q1 24
$80.7M
$82.3M
Total Debt
ASRT
ASRT
SPRO
SPRO
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24
$38.6M
Stockholders' Equity
ASRT
ASRT
SPRO
SPRO
Q4 25
$94.0M
$59.0M
Q3 25
$105.8M
$26.5M
Q2 25
$93.3M
$32.8M
Q1 25
$108.5M
$33.8M
Q4 24
$121.1M
$46.1M
Q3 24
$130.5M
$65.5M
Q2 24
$132.2M
$80.5M
Q1 24
$134.5M
$96.2M
Total Assets
ASRT
ASRT
SPRO
SPRO
Q4 25
$267.0M
$68.9M
Q3 25
$319.8M
$54.2M
Q2 25
$273.8M
$62.1M
Q1 25
$286.4M
$77.7M
Q4 24
$284.7M
$110.5M
Q3 24
$276.0M
$135.2M
Q2 24
$279.4M
$149.9M
Q1 24
$282.0M
$167.7M
Debt / Equity
ASRT
ASRT
SPRO
SPRO
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24
0.29×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ASRT
ASRT
SPRO
SPRO
Operating Cash FlowLast quarter
$-30.0M
$-8.4M
Free Cash FlowOCF − Capex
FCF MarginFCF / Revenue
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
-0.26×
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ASRT
ASRT
SPRO
SPRO
Q4 25
$-30.0M
$-8.4M
Q3 25
$-4.8M
$17.4M
Q2 25
$19.1M
$-17.7M
Q1 25
$-12.5M
$-4.0M
Q4 24
$11.5M
$-23.4M
Q3 24
$-35.0K
$12.8M
Q2 24
$7.4M
$-18.7M
Q1 24
$7.5M
$5.9M
Capex Intensity
ASRT
ASRT
SPRO
SPRO
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
Q3 24
0.0%
Q2 24
Q1 24
Cash Conversion
ASRT
ASRT
SPRO
SPRO
Q4 25
-0.26×
Q3 25
-0.42×
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ASRT
ASRT

Products$12.8M95%
Other$719.0K5%

SPRO
SPRO

Segment breakdown not available.

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