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Side-by-side financial comparison of Avidity Biosciences, Inc. (RNA) and Spero Therapeutics, Inc. (SPRO). Click either name above to swap in a different company.
Spero Therapeutics, Inc. is the larger business by last-quarter revenue ($12.6M vs $12.5M, roughly 1.0× Avidity Biosciences, Inc.). Spero Therapeutics, Inc. runs the higher net margin — 250.7% vs -1398.3%, a 1649.0% gap on every dollar of revenue. On growth, Spero Therapeutics, Inc. posted the faster year-over-year revenue change (24080.8% vs 434.0%). Over the past eight quarters, Spero Therapeutics, Inc.'s revenue compounded faster (847.7% CAGR vs 138.5%).
Eli Lilly and Company, doing business as Lilly, is an American multinational pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by Eli Lilly, a pharmaceutical chemist and Union army veteran during the American Civil War for whom the company was later named.
RNA vs SPRO — Head-to-Head
Income Statement — Q3 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $12.5M | $12.6M |
| Net Profit | $-174.4M | $31.5M |
| Gross Margin | — | — |
| Operating Margin | -1513.5% | — |
| Net Margin | -1398.3% | 250.7% |
| Revenue YoY | 434.0% | 24080.8% |
| Net Profit YoY | -117.0% | 250.9% |
| EPS (diluted) | $-1.27 | $0.56 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $12.6M | ||
| Q3 25 | $12.5M | $0 | ||
| Q2 25 | $3.8M | $0 | ||
| Q1 25 | $1.6M | $12.0K | ||
| Q4 24 | $3.0M | $52.0K | ||
| Q3 24 | $2.3M | $65.0K | ||
| Q2 24 | $2.0M | $114.0K | ||
| Q1 24 | $3.5M | $140.0K |
| Q4 25 | — | $31.5M | ||
| Q3 25 | $-174.4M | $-7.4M | ||
| Q2 25 | $-157.3M | $-1.7M | ||
| Q1 25 | $-115.8M | $-13.9M | ||
| Q4 24 | $-102.3M | — | ||
| Q3 24 | $-80.4M | $-17.1M | ||
| Q2 24 | $-70.8M | $-17.9M | ||
| Q1 24 | $-68.9M | $-12.7M |
| Q4 25 | — | — | ||
| Q3 25 | -1513.5% | — | ||
| Q2 25 | -4448.7% | — | ||
| Q1 25 | -8360.9% | -122758.3% | ||
| Q4 24 | -4069.6% | — | ||
| Q3 24 | -4200.9% | -28604.6% | ||
| Q2 24 | -4040.4% | -16720.2% | ||
| Q1 24 | -2178.6% | -9987.1% |
| Q4 25 | — | 250.7% | ||
| Q3 25 | -1398.3% | — | ||
| Q2 25 | -4089.3% | — | ||
| Q1 25 | -7360.0% | -115550.0% | ||
| Q4 24 | -3439.5% | — | ||
| Q3 24 | -3441.7% | -26380.0% | ||
| Q2 24 | -3461.8% | -15668.4% | ||
| Q1 24 | -1943.4% | -9049.3% |
| Q4 25 | — | $0.56 | ||
| Q3 25 | $-1.27 | $-0.13 | ||
| Q2 25 | $-1.21 | $-0.03 | ||
| Q1 25 | $-0.90 | $-0.25 | ||
| Q4 24 | $-0.80 | — | ||
| Q3 24 | $-0.65 | $-0.32 | ||
| Q2 24 | $-0.65 | $-0.33 | ||
| Q1 24 | $-0.79 | $-0.24 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $350.2M | $40.3M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.9B | $59.0M |
| Total Assets | $2.1B | $68.9M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $40.3M | ||
| Q3 25 | $350.2M | $48.6M | ||
| Q2 25 | $243.9M | $31.2M | ||
| Q1 25 | $254.2M | $48.9M | ||
| Q4 24 | $219.9M | $52.9M | ||
| Q3 24 | $370.2M | $76.3M | ||
| Q2 24 | $575.8M | $63.5M | ||
| Q1 24 | $471.4M | $82.3M |
| Q4 25 | — | $59.0M | ||
| Q3 25 | $1.9B | $26.5M | ||
| Q2 25 | $1.2B | $32.8M | ||
| Q1 25 | $1.3B | $33.8M | ||
| Q4 24 | $1.4B | $46.1M | ||
| Q3 24 | $1.5B | $65.5M | ||
| Q2 24 | $1.2B | $80.5M | ||
| Q1 24 | $830.9M | $96.2M |
| Q4 25 | — | $68.9M | ||
| Q3 25 | $2.1B | $54.2M | ||
| Q2 25 | $1.4B | $62.1M | ||
| Q1 25 | $1.5B | $77.7M | ||
| Q4 24 | $1.6B | $110.5M | ||
| Q3 24 | $1.6B | $135.2M | ||
| Q2 24 | $1.3B | $149.9M | ||
| Q1 24 | $951.5M | $167.7M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-156.2M | $-8.4M |
| Free Cash FlowOCF − Capex | $-156.9M | — |
| FCF MarginFCF / Revenue | -1257.6% | — |
| Capex IntensityCapex / Revenue | 5.7% | — |
| Cash ConversionOCF / Net Profit | — | -0.26× |
| TTM Free Cash FlowTrailing 4 quarters | $-592.3M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $-8.4M | ||
| Q3 25 | $-156.2M | $17.4M | ||
| Q2 25 | $-199.7M | $-17.7M | ||
| Q1 25 | $-124.8M | $-4.0M | ||
| Q4 24 | $-99.9M | $-23.4M | ||
| Q3 24 | $-65.6M | $12.8M | ||
| Q2 24 | $-65.0M | $-18.7M | ||
| Q1 24 | $-70.4M | $5.9M |
| Q4 25 | — | — | ||
| Q3 25 | $-156.9M | — | ||
| Q2 25 | $-203.0M | — | ||
| Q1 25 | $-128.6M | — | ||
| Q4 24 | $-103.8M | — | ||
| Q3 24 | $-67.3M | — | ||
| Q2 24 | $-65.5M | — | ||
| Q1 24 | $-71.3M | — |
| Q4 25 | — | — | ||
| Q3 25 | -1257.6% | — | ||
| Q2 25 | -5277.1% | — | ||
| Q1 25 | -8174.3% | — | ||
| Q4 24 | -3491.0% | — | ||
| Q3 24 | -2881.8% | — | ||
| Q2 24 | -3204.6% | — | ||
| Q1 24 | -2012.3% | — |
| Q4 25 | — | — | ||
| Q3 25 | 5.7% | — | ||
| Q2 25 | 86.9% | — | ||
| Q1 25 | 238.6% | — | ||
| Q4 24 | 131.7% | — | ||
| Q3 24 | 72.9% | — | ||
| Q2 24 | 26.0% | — | ||
| Q1 24 | 25.8% | — |
| Q4 25 | — | -0.26× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
