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Side-by-side financial comparison of American Express (AXP) and CRISPR Therapeutics AG (CRSP). Click either name above to swap in a different company.
CRISPR Therapeutics AG is the larger business by last-quarter revenue ($35.7M vs $18.9M, roughly 1.9× American Express). American Express runs the higher net margin — 15.7% vs -104.5%, a 120.3% gap on every dollar of revenue. On growth, American Express posted the faster year-over-year revenue change (11.4% vs -82.3%).
American Express Company, together with its subsidiaries, provides charge and credit payment card products, and travel-related services worldwide. The company operates through three segments: Global Consumer Services Group, Global Commercial Services, and Global Merchant and Network Services. Its products and services include payment and financing products; network services; accounts payable expense management products and services; and travel and lifestyle services. The company's products an...
CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. The company does business as CRISPR Therapeutics, Inc. in the United States. It was one of the first companies formed to utilize the CRISPR gene editing platform to develop medicines for the treatment of various rare and common diseases. The company has approximately 500 employees and has offices in Zug, Switzerland, Boston, Massachusetts, San Francisco, California and London, United Kingdom. I...
AXP vs CRSP — Head-to-Head
Income Statement — Q1 FY2026 vs Q4 FY2024
| Metric | | |
|---|---|---|
| Revenue | $18.9M | $35.7M |
| Net Profit | $3.0M | $-37.3M |
| Gross Margin | — | — |
| Operating Margin | — | -181.0% |
| Net Margin | 15.7% | -104.5% |
| Revenue YoY | 11.4% | -82.3% |
| Net Profit YoY | 15.0% | -141.8% |
| EPS (diluted) | — | $-0.41 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | $18.9M | — | ||
| Q4 25 | $10.9B | — | ||
| Q3 25 | $10.4B | — | ||
| Q2 25 | $10.3B | — | ||
| Q1 25 | $9.6B | — | ||
| Q4 24 | $10.0B | $35.7M | ||
| Q3 24 | $9.7B | — | ||
| Q2 24 | $9.8B | — |
| Q1 26 | $3.0M | — | ||
| Q4 25 | $2.5B | — | ||
| Q3 25 | $2.9B | — | ||
| Q2 25 | $2.9B | — | ||
| Q1 25 | $2.6B | — | ||
| Q4 24 | $2.2B | $-37.3M | ||
| Q3 24 | $2.5B | — | ||
| Q2 24 | $3.0B | — |
| Q1 26 | — | — | ||
| Q4 25 | 28.2% | — | ||
| Q3 25 | 36.7% | — | ||
| Q2 25 | 34.4% | — | ||
| Q1 25 | 34.6% | — | ||
| Q4 24 | 27.7% | -181.0% | ||
| Q3 24 | 33.0% | — | ||
| Q2 24 | 38.6% | — |
| Q1 26 | 15.7% | — | ||
| Q4 25 | 22.5% | — | ||
| Q3 25 | 27.9% | — | ||
| Q2 25 | 28.0% | — | ||
| Q1 25 | 26.8% | — | ||
| Q4 24 | 21.8% | -104.5% | ||
| Q3 24 | 25.8% | — | ||
| Q2 24 | 30.7% | — |
| Q1 26 | — | — | ||
| Q4 25 | $3.52 | — | ||
| Q3 25 | $4.14 | — | ||
| Q2 25 | $4.08 | — | ||
| Q1 25 | $3.64 | — | ||
| Q4 24 | $3.04 | $-0.41 | ||
| Q3 24 | $3.49 | — | ||
| Q2 24 | $4.15 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | — | $1.9B |
| Total DebtLower is stronger | $60.4M | — |
| Stockholders' EquityBook value | $34.0M | $1.9B |
| Total Assets | $308.9M | $2.2B |
| Debt / EquityLower = less leverage | 1.78× | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $742.0M | — | ||
| Q3 25 | $1.3B | — | ||
| Q2 25 | $197.0M | — | ||
| Q1 25 | $261.0M | — | ||
| Q4 24 | $221.0M | $1.9B | ||
| Q3 24 | $120.0M | — | ||
| Q2 24 | $188.0M | — |
| Q1 26 | $60.4M | — | ||
| Q4 25 | $56.4B | — | ||
| Q3 25 | $57.8B | — | ||
| Q2 25 | $58.2B | — | ||
| Q1 25 | $51.2B | — | ||
| Q4 24 | $49.7B | — | ||
| Q3 24 | $53.5B | — | ||
| Q2 24 | $51.5B | — |
| Q1 26 | $34.0M | — | ||
| Q4 25 | $33.5B | — | ||
| Q3 25 | $32.4B | — | ||
| Q2 25 | $32.3B | — | ||
| Q1 25 | $31.2B | — | ||
| Q4 24 | $30.3B | $1.9B | ||
| Q3 24 | $29.7B | — | ||
| Q2 24 | $29.5B | — |
| Q1 26 | $308.9M | — | ||
| Q4 25 | $300.1B | — | ||
| Q3 25 | $297.6B | — | ||
| Q2 25 | $295.6B | — | ||
| Q1 25 | $282.2B | — | ||
| Q4 24 | $271.5B | $2.2B | ||
| Q3 24 | $271.0B | — | ||
| Q2 24 | $272.2B | — |
| Q1 26 | 1.78× | — | ||
| Q4 25 | 1.68× | — | ||
| Q3 25 | 1.78× | — | ||
| Q2 25 | 1.80× | — | ||
| Q1 25 | 1.64× | — | ||
| Q4 24 | 1.64× | — | ||
| Q3 24 | 1.80× | — | ||
| Q2 24 | 1.74× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | — | $-50.0M |
| Free Cash FlowOCF − Capex | — | $-50.3M |
| FCF MarginFCF / Revenue | — | -140.9% |
| Capex IntensityCapex / Revenue | — | 0.7% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-325.9M |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $3.1B | — | ||
| Q3 25 | $6.2B | — | ||
| Q2 25 | $4.4B | — | ||
| Q1 25 | $4.8B | — | ||
| Q4 24 | $5.8B | $-50.0M | ||
| Q3 24 | $-1.8B | — | ||
| Q2 24 | $4.5B | — |
| Q1 26 | — | — | ||
| Q4 25 | $2.3B | — | ||
| Q3 25 | $5.6B | — | ||
| Q2 25 | $3.7B | — | ||
| Q1 25 | $4.3B | — | ||
| Q4 24 | $5.3B | $-50.3M | ||
| Q3 24 | $-2.3B | — | ||
| Q2 24 | $4.0B | — |
| Q1 26 | — | — | ||
| Q4 25 | 21.4% | — | ||
| Q3 25 | 53.6% | — | ||
| Q2 25 | 36.3% | — | ||
| Q1 25 | 45.0% | — | ||
| Q4 24 | 53.1% | -140.9% | ||
| Q3 24 | -23.3% | — | ||
| Q2 24 | 40.4% | — |
| Q1 26 | — | — | ||
| Q4 25 | 6.6% | — | ||
| Q3 25 | 6.3% | — | ||
| Q2 25 | 6.0% | — | ||
| Q1 25 | 4.5% | — | ||
| Q4 24 | 5.0% | 0.7% | ||
| Q3 24 | 4.7% | — | ||
| Q2 24 | 5.8% | — |
| Q1 26 | — | — | ||
| Q4 25 | 1.25× | — | ||
| Q3 25 | 2.15× | — | ||
| Q2 25 | 1.51× | — | ||
| Q1 25 | 1.84× | — | ||
| Q4 24 | 2.66× | — | ||
| Q3 24 | -0.72× | — | ||
| Q2 24 | 1.50× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AXP
| Discount revenue | $9.5M | 50% |
| Other | $8.9M | 47% |
| Deposits with banks and other | $512.0K | 3% |
CRSP
| Collaboration Revenue | $35.0M | 98% |
| Grant | $2.3M | 6% |
