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Side-by-side financial comparison of Axsome Therapeutics, Inc. (AXSM) and Vertex, Inc. (VERX). Click either name above to swap in a different company.
Axsome Therapeutics, Inc. is the larger business by last-quarter revenue ($196.0M vs $194.7M, roughly 1.0× Vertex, Inc.). Vertex, Inc. runs the higher net margin — -3.6% vs -14.6%, a 11.0% gap on every dollar of revenue. On growth, Axsome Therapeutics, Inc. posted the faster year-over-year revenue change (65.0% vs 9.1%). Over the past eight quarters, Axsome Therapeutics, Inc.'s revenue compounded faster (61.7% CAGR vs 11.4%).
Jazz Pharmaceuticals plc is a global biopharmaceutical company with a focus on oncology and neuroscience. It was founded in 2003 in California, United States and is now headquartered in Dublin, Ireland.
Vertex Pharmaceuticals Incorporated is an American biopharmaceutical company based in Boston, Massachusetts. It was one of the first biotech firms to use an explicit strategy of rational drug design rather than combinatorial chemistry. It maintains headquarters in Boston, Massachusetts, and three research facilities, in San Diego, California, and Milton Park, Oxfordshire, England.
AXSM vs VERX — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $196.0M | $194.7M |
| Net Profit | $-28.6M | $-7.0M |
| Gross Margin | — | 64.8% |
| Operating Margin | -13.8% | -1.3% |
| Net Margin | -14.6% | -3.6% |
| Revenue YoY | 65.0% | 9.1% |
| Net Profit YoY | 61.9% | 89.7% |
| EPS (diluted) | $-0.55 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $196.0M | $194.7M | ||
| Q3 25 | $171.0M | $192.1M | ||
| Q2 25 | $150.0M | $184.6M | ||
| Q1 25 | $121.5M | $177.1M | ||
| Q4 24 | $118.8M | $178.5M | ||
| Q3 24 | $104.8M | $170.4M | ||
| Q2 24 | $87.2M | $161.1M | ||
| Q1 24 | $75.0M | $156.8M |
| Q4 25 | $-28.6M | $-7.0M | ||
| Q3 25 | $-47.2M | $4.0M | ||
| Q2 25 | $-48.0M | $-961.0K | ||
| Q1 25 | $-59.4M | $11.1M | ||
| Q4 24 | $-74.9M | $-67.8M | ||
| Q3 24 | $-64.6M | $7.2M | ||
| Q2 24 | $-79.3M | $5.2M | ||
| Q1 24 | $-68.4M | $2.7M |
| Q4 25 | — | 64.8% | ||
| Q3 25 | — | 63.1% | ||
| Q2 25 | — | 65.7% | ||
| Q1 25 | — | 63.8% | ||
| Q4 24 | — | 65.6% | ||
| Q3 24 | — | 64.8% | ||
| Q2 24 | — | 63.7% | ||
| Q1 24 | — | 61.1% |
| Q4 25 | -13.8% | -1.3% | ||
| Q3 25 | -27.0% | 2.2% | ||
| Q2 25 | -24.5% | -2.1% | ||
| Q1 25 | -46.9% | 2.5% | ||
| Q4 24 | -61.1% | -7.3% | ||
| Q3 24 | -59.8% | 2.9% | ||
| Q2 24 | -89.5% | 4.7% | ||
| Q1 24 | -89.7% | -1.0% |
| Q4 25 | -14.6% | -3.6% | ||
| Q3 25 | -27.6% | 2.1% | ||
| Q2 25 | -32.0% | -0.5% | ||
| Q1 25 | -48.9% | 6.3% | ||
| Q4 24 | -63.1% | -38.0% | ||
| Q3 24 | -61.7% | 4.2% | ||
| Q2 24 | -91.0% | 3.2% | ||
| Q1 24 | -91.1% | 1.7% |
| Q4 25 | $-0.55 | — | ||
| Q3 25 | $-0.94 | — | ||
| Q2 25 | $-0.97 | — | ||
| Q1 25 | $-1.22 | — | ||
| Q4 24 | $-1.54 | — | ||
| Q3 24 | $-1.34 | — | ||
| Q2 24 | $-1.67 | — | ||
| Q1 24 | $-1.44 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $322.9M | $314.0M |
| Total DebtLower is stronger | — | $337.5M |
| Stockholders' EquityBook value | $88.3M | $258.9M |
| Total Assets | $689.8M | $1.3B |
| Debt / EquityLower = less leverage | — | 1.30× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $322.9M | $314.0M | ||
| Q3 25 | $325.3M | $313.5M | ||
| Q2 25 | $303.0M | $284.4M | ||
| Q1 25 | $300.9M | $270.4M | ||
| Q4 24 | $315.4M | $296.1M | ||
| Q3 24 | $327.3M | $279.0M | ||
| Q2 24 | $315.7M | $325.5M | ||
| Q1 24 | $331.4M | $56.1M |
| Q4 25 | — | $337.5M | ||
| Q3 25 | — | $336.9M | ||
| Q2 25 | — | $336.3M | ||
| Q1 25 | — | $335.8M | ||
| Q4 24 | — | $335.2M | ||
| Q3 24 | — | $334.7M | ||
| Q2 24 | — | $334.1M | ||
| Q1 24 | — | $46.0M |
| Q4 25 | $88.3M | $258.9M | ||
| Q3 25 | $73.7M | $264.5M | ||
| Q2 25 | $73.1M | $248.0M | ||
| Q1 25 | $53.2M | $200.5M | ||
| Q4 24 | $57.0M | $179.4M | ||
| Q3 24 | $92.9M | $259.0M | ||
| Q2 24 | $102.9M | $233.1M | ||
| Q1 24 | $144.0M | $250.1M |
| Q4 25 | $689.8M | $1.3B | ||
| Q3 25 | $669.3M | $1.2B | ||
| Q2 25 | $639.8M | $1.2B | ||
| Q1 25 | $596.7M | $1.2B | ||
| Q4 24 | $568.5M | $1.2B | ||
| Q3 24 | $561.5M | $1.2B | ||
| Q2 24 | $548.2M | $1.0B | ||
| Q1 24 | $545.7M | $755.8M |
| Q4 25 | — | 1.30× | ||
| Q3 25 | — | 1.27× | ||
| Q2 25 | — | 1.36× | ||
| Q1 25 | — | 1.67× | ||
| Q4 24 | — | 1.87× | ||
| Q3 24 | — | 1.29× | ||
| Q2 24 | — | 1.43× | ||
| Q1 24 | — | 0.18× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-18.7M | $42.3M |
| Free Cash FlowOCF − Capex | $-18.7M | — |
| FCF MarginFCF / Revenue | -9.6% | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-93.9M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-18.7M | $42.3M | ||
| Q3 25 | $1.0M | $62.5M | ||
| Q2 25 | $-32.4M | $46.0M | ||
| Q1 25 | $-43.4M | $14.8M | ||
| Q4 24 | $-26.2M | $41.1M | ||
| Q3 24 | $-18.6M | $41.4M | ||
| Q2 24 | $-30.1M | $57.7M | ||
| Q1 24 | $-53.5M | $24.6M |
| Q4 25 | $-18.7M | — | ||
| Q3 25 | $988.0K | — | ||
| Q2 25 | $-32.4M | — | ||
| Q1 25 | $-43.7M | — | ||
| Q4 24 | $-26.2M | — | ||
| Q3 24 | $-18.7M | $-24.3M | ||
| Q2 24 | $-30.2M | — | ||
| Q1 24 | $-53.6M | $10.1M |
| Q4 25 | -9.6% | — | ||
| Q3 25 | 0.6% | — | ||
| Q2 25 | -21.6% | — | ||
| Q1 25 | -36.0% | — | ||
| Q4 24 | -22.1% | — | ||
| Q3 24 | -17.9% | -14.2% | ||
| Q2 24 | -34.6% | — | ||
| Q1 24 | -71.4% | 6.5% |
| Q4 25 | 0.0% | — | ||
| Q3 25 | 0.0% | — | ||
| Q2 25 | 0.0% | — | ||
| Q1 25 | 0.3% | — | ||
| Q4 24 | 0.0% | — | ||
| Q3 24 | 0.1% | 38.5% | ||
| Q2 24 | 0.1% | — | ||
| Q1 24 | 0.1% | 9.2% |
| Q4 25 | — | — | ||
| Q3 25 | — | 15.44× | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 1.33× | ||
| Q4 24 | — | — | ||
| Q3 24 | — | 5.73× | ||
| Q2 24 | — | 11.18× | ||
| Q1 24 | — | 9.15× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AXSM
Segment breakdown not available.
VERX
| Cloud Subscriptions | $94.6M | 49% |
| Software Licenses | $71.6M | 37% |
| Service Other | $28.5M | 15% |
