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Side-by-side financial comparison of BYLINE BANCORP, INC. (BY) and OPKO HEALTH, INC. (OPK). Click either name above to swap in a different company.
OPKO HEALTH, INC. is the larger business by last-quarter revenue ($148.5M vs $112.4M, roughly 1.3× BYLINE BANCORP, INC.). BYLINE BANCORP, INC. runs the higher net margin — 33.4% vs -21.1%, a 54.5% gap on every dollar of revenue. On growth, BYLINE BANCORP, INC. posted the faster year-over-year revenue change (9.0% vs -19.2%). Over the past eight quarters, BYLINE BANCORP, INC.'s revenue compounded faster (6.4% CAGR vs -7.5%).
Byline Bank is a bank headquartered in Chicago, Illinois, United States. It is the primary subsidiary of Byline Bancorp, Inc., a bank holding company, and the 4th largest SBA 7(a) lender.
OPKO Health, Inc. is a medical test and medication company focused on diagnostics and pharmaceuticals. The company is a publicly traded company on NASDAQ and TASE under the symbol "OPK".
BY vs OPK — Head-to-Head
Income Statement — Q1 FY2026 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $112.4M | $148.5M |
| Net Profit | $37.6M | $-31.3M |
| Gross Margin | — | 43.1% |
| Operating Margin | — | -25.8% |
| Net Margin | 33.4% | -21.1% |
| Revenue YoY | 9.0% | -19.2% |
| Net Profit YoY | 33.0% | -322.8% |
| EPS (diluted) | $0.83 | $-0.04 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | $112.4M | — | ||
| Q4 25 | $117.0M | $148.5M | ||
| Q3 25 | $115.7M | $151.7M | ||
| Q2 25 | $110.5M | $156.8M | ||
| Q1 25 | $103.1M | $150.0M | ||
| Q4 24 | $104.7M | $183.6M | ||
| Q3 24 | $101.8M | $173.6M | ||
| Q2 24 | $99.4M | $182.2M |
| Q1 26 | $37.6M | — | ||
| Q4 25 | $34.5M | $-31.3M | ||
| Q3 25 | $37.2M | $21.6M | ||
| Q2 25 | $30.1M | $-148.4M | ||
| Q1 25 | $28.2M | $-67.6M | ||
| Q4 24 | $30.3M | $14.0M | ||
| Q3 24 | $30.3M | $24.9M | ||
| Q2 24 | $29.7M | $-10.3M |
| Q1 26 | — | — | ||
| Q4 25 | — | 43.1% | ||
| Q3 25 | — | 32.9% | ||
| Q2 25 | — | 31.5% | ||
| Q1 25 | — | 28.4% | ||
| Q4 24 | — | 46.1% | ||
| Q3 24 | — | 23.1% | ||
| Q2 24 | — | 28.4% |
| Q1 26 | — | — | ||
| Q4 25 | 40.1% | -25.8% | ||
| Q3 25 | 43.1% | 31.7% | ||
| Q2 25 | 35.2% | -38.3% | ||
| Q1 25 | 36.4% | -44.8% | ||
| Q4 24 | 38.6% | -18.0% | ||
| Q3 24 | 39.3% | 8.2% | ||
| Q2 24 | 40.4% | -33.9% |
| Q1 26 | 33.4% | — | ||
| Q4 25 | 34.1% | -21.1% | ||
| Q3 25 | 32.1% | 14.3% | ||
| Q2 25 | 27.2% | -94.7% | ||
| Q1 25 | 27.4% | -45.1% | ||
| Q4 24 | 34.3% | 7.6% | ||
| Q3 24 | 29.8% | 14.3% | ||
| Q2 24 | 29.9% | -5.7% |
| Q1 26 | $0.83 | — | ||
| Q4 25 | $0.77 | $-0.04 | ||
| Q3 25 | $0.82 | $0.03 | ||
| Q2 25 | $0.66 | $-0.19 | ||
| Q1 25 | $0.64 | $-0.10 | ||
| Q4 24 | $0.68 | $0.02 | ||
| Q3 24 | $0.69 | $0.03 | ||
| Q2 24 | $0.68 | $-0.01 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $198.4M | $364.4M |
| Total DebtLower is stronger | — | $344.0M |
| Stockholders' EquityBook value | $1.3B | $1.3B |
| Total Assets | $9.9B | $1.9B |
| Debt / EquityLower = less leverage | — | 0.27× |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | $198.4M | — | ||
| Q4 25 | $149.1M | $364.4M | ||
| Q3 25 | $259.0M | $412.0M | ||
| Q2 25 | $218.3M | $267.3M | ||
| Q1 25 | $421.3M | $428.8M | ||
| Q4 24 | $563.1M | $426.6M | ||
| Q3 24 | $452.6M | $400.1M | ||
| Q2 24 | $730.5M | $40.6M |
| Q1 26 | — | — | ||
| Q4 25 | — | $344.0M | ||
| Q3 25 | — | $344.2M | ||
| Q2 25 | — | $343.3M | ||
| Q1 25 | — | $439.2M | ||
| Q4 24 | — | $437.2M | ||
| Q3 24 | — | $441.0M | ||
| Q2 24 | — | $201.9M |
| Q1 26 | $1.3B | — | ||
| Q4 25 | $1.3B | $1.3B | ||
| Q3 25 | $1.2B | $1.3B | ||
| Q2 25 | $1.2B | $1.3B | ||
| Q1 25 | $1.1B | $1.3B | ||
| Q4 24 | $1.1B | $1.4B | ||
| Q3 24 | $1.1B | $1.4B | ||
| Q2 24 | $1.0B | $1.4B |
| Q1 26 | $9.9B | — | ||
| Q4 25 | $9.7B | $1.9B | ||
| Q3 25 | $9.8B | $2.0B | ||
| Q2 25 | $9.7B | $2.0B | ||
| Q1 25 | $9.6B | $2.1B | ||
| Q4 24 | $9.5B | $2.2B | ||
| Q3 24 | $9.4B | $2.3B | ||
| Q2 24 | $9.6B | $2.0B |
| Q1 26 | — | — | ||
| Q4 25 | — | 0.27× | ||
| Q3 25 | — | 0.26× | ||
| Q2 25 | — | 0.26× | ||
| Q1 25 | — | 0.33× | ||
| Q4 24 | — | 0.32× | ||
| Q3 24 | — | 0.31× | ||
| Q2 24 | — | 0.14× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | — | $-25.9M |
| Free Cash FlowOCF − Capex | — | $-28.6M |
| FCF MarginFCF / Revenue | — | -19.3% |
| Capex IntensityCapex / Revenue | — | 1.8% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-190.8M |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $140.3M | $-25.9M | ||
| Q3 25 | $38.3M | $-34.6M | ||
| Q2 25 | $16.3M | $-83.4M | ||
| Q1 25 | $27.1M | $-34.6M | ||
| Q4 24 | $175.2M | $-44.4M | ||
| Q3 24 | $19.8M | $-77.1M | ||
| Q2 24 | $40.1M | $-26.4M |
| Q1 26 | — | — | ||
| Q4 25 | $136.3M | $-28.6M | ||
| Q3 25 | $38.0M | $-37.8M | ||
| Q2 25 | $15.2M | $-86.7M | ||
| Q1 25 | $25.0M | $-37.7M | ||
| Q4 24 | $171.2M | $-49.8M | ||
| Q3 24 | $19.1M | $-85.0M | ||
| Q2 24 | $39.4M | $-33.7M |
| Q1 26 | — | — | ||
| Q4 25 | 116.5% | -19.3% | ||
| Q3 25 | 32.8% | -24.9% | ||
| Q2 25 | 13.7% | -55.3% | ||
| Q1 25 | 24.3% | -25.2% | ||
| Q4 24 | 163.5% | -27.1% | ||
| Q3 24 | 18.8% | -49.0% | ||
| Q2 24 | 39.7% | -18.5% |
| Q1 26 | — | — | ||
| Q4 25 | 3.4% | 1.8% | ||
| Q3 25 | 0.3% | 2.1% | ||
| Q2 25 | 1.0% | 2.1% | ||
| Q1 25 | 2.0% | 2.1% | ||
| Q4 24 | 3.8% | 2.9% | ||
| Q3 24 | 0.6% | 4.6% | ||
| Q2 24 | 0.7% | 4.0% |
| Q1 26 | — | — | ||
| Q4 25 | 4.06× | — | ||
| Q3 25 | 1.03× | -1.60× | ||
| Q2 25 | 0.54× | — | ||
| Q1 25 | 0.96× | — | ||
| Q4 24 | 5.78× | -3.17× | ||
| Q3 24 | 0.65× | -3.10× | ||
| Q2 24 | 1.35× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
BY
Segment breakdown not available.
OPK
| Services | $71.1M | 48% |
| Transfer Of Intellectual Property And Other | $33.7M | 23% |
| IE | $22.1M | 15% |
| Rayaldee | $8.8M | 6% |
| Barda Agreement | $6.8M | 5% |
| MX | $6.3M | 4% |
