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Side-by-side financial comparison of CULLEN/FROST BANKERS, INC. (CFR) and MADRIGAL PHARMACEUTICALS, INC. (MDGL). Click either name above to swap in a different company.
CULLEN/FROST BANKERS, INC. is the larger business by last-quarter revenue ($580.9M vs $321.1M, roughly 1.8× MADRIGAL PHARMACEUTICALS, INC.). CULLEN/FROST BANKERS, INC. runs the higher net margin — 28.6% vs -18.2%, a 46.9% gap on every dollar of revenue. On growth, MADRIGAL PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (210.8% vs 8.3%). CULLEN/FROST BANKERS, INC. produced more free cash flow last quarter ($127.3M vs $-133.8M).
Frost Bank is an American bank based in San Antonio that is chartered in Texas, with 200 branches and 1,750 automated teller machines in the state. It is the primary subsidiary of Cullen/Frost Bankers, Inc., a bank holding company. It is one of the 60 largest banks of the country by total assets.
Intercept Pharmaceuticals, Inc. is an American biopharmaceutical company incorporated in 2002, focusing on the development of novel synthetic bile acid analogs to treat chronic liver diseases, such as primary biliary cirrhosis (PBC) now called primary biliary cholangitis, non-alcoholic fatty liver disease, cirrhosis, portal hypertension, primary sclerosing cholangitis and also the intestinal disorder, bile acid diarrhea.
CFR vs MDGL — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $580.9M | $321.1M |
| Net Profit | $166.3M | $-58.6M |
| Gross Margin | — | — |
| Operating Margin | 34.1% | -18.6% |
| Net Margin | 28.6% | -18.2% |
| Revenue YoY | 8.3% | 210.8% |
| Net Profit YoY | 7.4% | 1.4% |
| EPS (diluted) | $2.56 | $-2.55 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $580.9M | $321.1M | ||
| Q3 25 | $567.3M | $287.3M | ||
| Q2 25 | $546.9M | $212.8M | ||
| Q1 25 | $540.2M | $137.3M | ||
| Q4 24 | $536.3M | $103.3M | ||
| Q3 24 | $518.0M | $62.2M | ||
| Q2 24 | $507.9M | — | ||
| Q1 24 | $501.4M | $0 |
| Q4 25 | $166.3M | $-58.6M | ||
| Q3 25 | $174.4M | $-114.2M | ||
| Q2 25 | $157.0M | $-42.3M | ||
| Q1 25 | $150.9M | $-73.2M | ||
| Q4 24 | $154.9M | $-59.4M | ||
| Q3 24 | $146.5M | $-107.0M | ||
| Q2 24 | $145.5M | — | ||
| Q1 24 | $135.7M | $-147.5M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 96.7% | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | 34.1% | -18.6% | ||
| Q3 25 | 36.7% | -39.7% | ||
| Q2 25 | 34.1% | -22.2% | ||
| Q1 25 | 33.2% | -57.8% | ||
| Q4 24 | 34.3% | -64.8% | ||
| Q3 24 | 33.8% | -187.1% | ||
| Q2 24 | 34.5% | — | ||
| Q1 24 | 32.2% | — |
| Q4 25 | 28.6% | -18.2% | ||
| Q3 25 | 30.7% | -39.8% | ||
| Q2 25 | 28.7% | -19.9% | ||
| Q1 25 | 27.9% | -53.4% | ||
| Q4 24 | 28.9% | -57.5% | ||
| Q3 24 | 28.3% | -172.0% | ||
| Q2 24 | 28.6% | — | ||
| Q1 24 | 27.1% | — |
| Q4 25 | $2.56 | $-2.55 | ||
| Q3 25 | $2.67 | $-5.08 | ||
| Q2 25 | $2.39 | $-1.90 | ||
| Q1 25 | $2.30 | $-3.32 | ||
| Q4 24 | $2.36 | $-2.50 | ||
| Q3 24 | $2.24 | $-4.92 | ||
| Q2 24 | $2.21 | — | ||
| Q1 24 | $2.06 | $-7.38 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | — | $198.7M |
| Total DebtLower is stronger | — | $339.9M |
| Stockholders' EquityBook value | $4.6B | $602.7M |
| Total Assets | $53.0B | $1.3B |
| Debt / EquityLower = less leverage | — | 0.56× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $198.7M | ||
| Q3 25 | — | $295.7M | ||
| Q2 25 | — | $186.2M | ||
| Q1 25 | — | $183.6M | ||
| Q4 24 | — | $100.0M | ||
| Q3 24 | — | $232.7M | ||
| Q2 24 | — | — | ||
| Q1 24 | — | $622.5M |
| Q4 25 | — | $339.9M | ||
| Q3 25 | — | $339.8M | ||
| Q2 25 | — | $118.4M | ||
| Q1 25 | — | $118.0M | ||
| Q4 24 | — | $117.6M | ||
| Q3 24 | — | $117.1M | ||
| Q2 24 | — | — | ||
| Q1 24 | — | $116.1M |
| Q4 25 | $4.6B | $602.7M | ||
| Q3 25 | $4.5B | $625.7M | ||
| Q2 25 | $4.2B | $696.0M | ||
| Q1 25 | $4.1B | $710.6M | ||
| Q4 24 | $3.9B | $754.4M | ||
| Q3 24 | $4.1B | $777.2M | ||
| Q2 24 | $3.7B | — | ||
| Q1 24 | $3.6B | $850.8M |
| Q4 25 | $53.0B | $1.3B | ||
| Q3 25 | $52.5B | $1.4B | ||
| Q2 25 | $51.4B | $1.0B | ||
| Q1 25 | $52.0B | $996.6M | ||
| Q4 24 | $52.5B | $1.0B | ||
| Q3 24 | $51.0B | $1.1B | ||
| Q2 24 | $48.8B | — | ||
| Q1 24 | $49.5B | $1.1B |
| Q4 25 | — | 0.56× | ||
| Q3 25 | — | 0.54× | ||
| Q2 25 | — | 0.17× | ||
| Q1 25 | — | 0.17× | ||
| Q4 24 | — | 0.16× | ||
| Q3 24 | — | 0.15× | ||
| Q2 24 | — | — | ||
| Q1 24 | — | 0.14× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $274.0M | $-133.5M |
| Free Cash FlowOCF − Capex | $127.3M | $-133.8M |
| FCF MarginFCF / Revenue | 21.9% | -41.7% |
| Capex IntensityCapex / Revenue | 25.2% | 0.1% |
| Cash ConversionOCF / Net Profit | 1.65× | — |
| TTM Free Cash FlowTrailing 4 quarters | $116.4M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $274.0M | $-133.5M | ||
| Q3 25 | $248.6M | $79.8M | ||
| Q2 25 | $140.8M | $-47.1M | ||
| Q1 25 | $-296.1M | $-88.9M | ||
| Q4 24 | $989.5M | $-104.5M | ||
| Q3 24 | $307.2M | $-67.0M | ||
| Q2 24 | $129.6M | — | ||
| Q1 24 | $488.4M | $-149.2M |
| Q4 25 | $127.3M | $-133.8M | ||
| Q3 25 | $211.7M | $79.0M | ||
| Q2 25 | $114.5M | — | ||
| Q1 25 | $-337.1M | — | ||
| Q4 24 | $861.8M | $-104.7M | ||
| Q3 24 | $281.9M | $-67.8M | ||
| Q2 24 | $103.0M | — | ||
| Q1 24 | $450.3M | $-149.5M |
| Q4 25 | 21.9% | -41.7% | ||
| Q3 25 | 37.3% | 27.5% | ||
| Q2 25 | 20.9% | — | ||
| Q1 25 | -62.4% | — | ||
| Q4 24 | 160.7% | -101.3% | ||
| Q3 24 | 54.4% | -109.0% | ||
| Q2 24 | 20.3% | — | ||
| Q1 24 | 89.8% | — |
| Q4 25 | 25.2% | 0.1% | ||
| Q3 25 | 6.5% | 0.3% | ||
| Q2 25 | 4.8% | 0.0% | ||
| Q1 25 | 7.6% | 0.0% | ||
| Q4 24 | 23.8% | 0.2% | ||
| Q3 24 | 4.9% | 1.3% | ||
| Q2 24 | 5.2% | — | ||
| Q1 24 | 7.6% | — |
| Q4 25 | 1.65× | — | ||
| Q3 25 | 1.43× | — | ||
| Q2 25 | 0.90× | — | ||
| Q1 25 | -1.96× | — | ||
| Q4 24 | 6.39× | — | ||
| Q3 24 | 2.10× | — | ||
| Q2 24 | 0.89× | — | ||
| Q1 24 | 3.60× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CFR
Segment breakdown not available.
MDGL
| Rebates Customer Fees Credits Co Pay Assistance And Other | $208.5M | 65% |
| Other | $76.0M | 24% |
| Chargebacks Discounts For Prompt Pay And Other Allowances | $36.6M | 11% |
