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Side-by-side financial comparison of COMERICA INC (CMA) and ILLUMINA, INC. (ILMN). Click either name above to swap in a different company.

ILLUMINA, INC. is the larger business by last-quarter revenue ($1.1B vs $838.0M, roughly 1.3× COMERICA INC). COMERICA INC runs the higher net margin — 21.0% vs 12.3%, a 8.7% gap on every dollar of revenue. On growth, ILLUMINA, INC. posted the faster year-over-year revenue change (4.8% vs 3.3%). Over the past eight quarters, COMERICA INC's revenue compounded faster (108.9% CAGR vs -1.3%).

Comerica Incorporated is an American financial services company, headquartered in Dallas, Texas. It is the parent of Comerica Bank, a regional commercial bank with 413 branches in the U.S. states of Texas, Michigan, California, Florida and Arizona. Comerica is among the largest U.S. financial holding companies, with offices in a number of U.S. cities.

Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets, and serves more than 155 countries.

CMA vs ILMN — Head-to-Head

Bigger by revenue
ILMN
ILMN
1.3× larger
ILMN
$1.1B
$838.0M
CMA
Growing faster (revenue YoY)
ILMN
ILMN
+1.5% gap
ILMN
4.8%
3.3%
CMA
Higher net margin
CMA
CMA
8.7% more per $
CMA
21.0%
12.3%
ILMN
Faster 2-yr revenue CAGR
CMA
CMA
Annualised
CMA
108.9%
-1.3%
ILMN

Income Statement — Q3 FY2025 vs Q1 FY2027

Metric
CMA
CMA
ILMN
ILMN
Revenue
$838.0M
$1.1B
Net Profit
$176.0M
$134.0M
Gross Margin
66.1%
Operating Margin
19.2%
Net Margin
21.0%
12.3%
Revenue YoY
3.3%
4.8%
Net Profit YoY
-4.3%
EPS (diluted)
$1.35
$0.87

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
CMA
CMA
ILMN
ILMN
Q1 26
$1.1B
Q4 25
$1.2B
Q3 25
$838.0M
Q2 25
$849.0M
Q1 25
$829.0M
Q4 24
$825.0M
$1.1B
Q3 24
$811.0M
$1.1B
Q2 24
$824.0M
$1.1B
Net Profit
CMA
CMA
ILMN
ILMN
Q1 26
$134.0M
Q4 25
$334.0M
Q3 25
$176.0M
Q2 25
$199.0M
Q1 25
$172.0M
Q4 24
$170.0M
$186.0M
Q3 24
$184.0M
$705.0M
Q2 24
$206.0M
$-2.0B
Gross Margin
CMA
CMA
ILMN
ILMN
Q1 26
66.1%
Q4 25
65.5%
Q3 25
Q2 25
Q1 25
Q4 24
65.9%
Q3 24
69.0%
Q2 24
64.8%
Operating Margin
CMA
CMA
ILMN
ILMN
Q1 26
19.2%
Q4 25
17.4%
Q3 25
Q2 25
Q1 25
Q4 24
15.8%
Q3 24
68.6%
Q2 24
-147.2%
Net Margin
CMA
CMA
ILMN
ILMN
Q1 26
12.3%
Q4 25
28.8%
Q3 25
21.0%
Q2 25
23.4%
Q1 25
20.7%
Q4 24
20.6%
16.8%
Q3 24
22.7%
65.3%
Q2 24
25.0%
-178.8%
EPS (diluted)
CMA
CMA
ILMN
ILMN
Q1 26
$0.87
Q4 25
$2.16
Q3 25
$1.35
Q2 25
$1.42
Q1 25
$1.25
Q4 24
$1.22
$1.16
Q3 24
$1.33
$4.42
Q2 24
$1.49
$-12.48

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
CMA
CMA
ILMN
ILMN
Cash + ST InvestmentsLiquidity on hand
$1.2B
Total DebtLower is stronger
$5.4B
Stockholders' EquityBook value
$7.4B
$2.7B
Total Assets
$77.4B
$6.6B
Debt / EquityLower = less leverage
0.73×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
CMA
CMA
ILMN
ILMN
Q1 26
$1.2B
Q4 25
$1.6B
Q3 25
Q2 25
Q1 25
Q4 24
$93.0M
Q3 24
$70.0M
Q2 24
$74.0M
Total Debt
CMA
CMA
ILMN
ILMN
Q1 26
Q4 25
Q3 25
$5.4B
Q2 25
$5.8B
Q1 25
$5.7B
Q4 24
$6.7B
Q3 24
$6.8B
Q2 24
$7.1B
Stockholders' Equity
CMA
CMA
ILMN
ILMN
Q1 26
$2.7B
Q4 25
$2.7B
Q3 25
$7.4B
Q2 25
$6.9B
Q1 25
$7.1B
Q4 24
$6.5B
$2.4B
Q3 24
$7.4B
$2.1B
Q2 24
$6.2B
$1.4B
Total Assets
CMA
CMA
ILMN
ILMN
Q1 26
$6.6B
Q4 25
$6.6B
Q3 25
$77.4B
Q2 25
$78.0B
Q1 25
$77.6B
Q4 24
$79.3B
$6.3B
Q3 24
$79.7B
$6.0B
Q2 24
$79.6B
$6.1B
Debt / Equity
CMA
CMA
ILMN
ILMN
Q1 26
Q4 25
Q3 25
0.73×
Q2 25
0.84×
Q1 25
0.81×
Q4 24
1.02×
Q3 24
0.92×
Q2 24
1.15×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
CMA
CMA
ILMN
ILMN
Operating Cash FlowLast quarter
$-270.0M
$289.0M
Free Cash FlowOCF − Capex
$251.0M
FCF MarginFCF / Revenue
23.0%
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
-1.53×
2.16×
TTM Free Cash FlowTrailing 4 quarters
$1.1B

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
CMA
CMA
ILMN
ILMN
Q1 26
$289.0M
Q4 25
$321.0M
Q3 25
$-270.0M
Q2 25
$476.0M
Q1 25
$273.0M
Q4 24
$601.0M
$364.0M
Q3 24
$1.0B
$316.0M
Q2 24
$111.0M
$80.0M
Free Cash Flow
CMA
CMA
ILMN
ILMN
Q1 26
$251.0M
Q4 25
$267.0M
Q3 25
Q2 25
Q1 25
Q4 24
$335.0M
Q3 24
$284.0M
Q2 24
$49.0M
FCF Margin
CMA
CMA
ILMN
ILMN
Q1 26
23.0%
Q4 25
23.0%
Q3 25
Q2 25
Q1 25
Q4 24
30.3%
Q3 24
26.3%
Q2 24
4.4%
Capex Intensity
CMA
CMA
ILMN
ILMN
Q1 26
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
2.6%
Q3 24
3.0%
Q2 24
2.8%
Cash Conversion
CMA
CMA
ILMN
ILMN
Q1 26
2.16×
Q4 25
0.96×
Q3 25
-1.53×
Q2 25
2.39×
Q1 25
1.59×
Q4 24
3.54×
1.96×
Q3 24
5.70×
0.45×
Q2 24
0.54×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

CMA
CMA

Segment breakdown not available.

ILMN
ILMN

Product revenue$917.0M84%
Service and other revenue$174.0M16%

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