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Side-by-side financial comparison of CATALYST PHARMACEUTICALS, INC. (CPRX) and PTC THERAPEUTICS, INC. (PTCT). Click either name above to swap in a different company.
PTC THERAPEUTICS, INC. is the larger business by last-quarter revenue ($164.7M vs $152.6M, roughly 1.1× CATALYST PHARMACEUTICALS, INC.). CATALYST PHARMACEUTICALS, INC. runs the higher net margin — 34.5% vs -82.0%, a 116.5% gap on every dollar of revenue. On growth, CATALYST PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (7.6% vs -22.7%). CATALYST PHARMACEUTICALS, INC. produced more free cash flow last quarter ($44.9M vs $-36.6M). Over the past eight quarters, CATALYST PHARMACEUTICALS, INC.'s revenue compounded faster (24.5% CAGR vs -11.5%).
Catalyst Pharmaceuticals, Inc. is a biopharmaceutical company based in Coral Gables, Florida, United States. The company develops medicines for rare diseases, including the phosphate salt of amifampridine for the treatment of Lambert–Eaton myasthenic syndrome (LEMS). The drug is referred to under the trade name Firdapse, which was approved by the FDA for approved use in children 6 years and older with LEMS in addition to the prior approval for use in adults with LEMS on November 28, 2018. Fir...
PTC Therapeutics, Inc. is a US pharmaceutical company focused on the development of orally administered small molecule drugs and gene therapy which regulate gene expression by targeting post-transcriptional control (PTC) mechanisms in orphan diseases.
CPRX vs PTCT — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $152.6M | $164.7M |
| Net Profit | $52.7M | $-135.0M |
| Gross Margin | 82.9% | — |
| Operating Margin | 40.5% | -43.3% |
| Net Margin | 34.5% | -82.0% |
| Revenue YoY | 7.6% | -22.7% |
| Net Profit YoY | -5.8% | -104.8% |
| EPS (diluted) | $0.40 | $-1.63 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $152.6M | $164.7M | ||
| Q3 25 | $148.4M | $211.0M | ||
| Q2 25 | $146.6M | $178.9M | ||
| Q1 25 | $141.4M | $1.2B | ||
| Q4 24 | $141.8M | $213.2M | ||
| Q3 24 | $128.7M | $196.8M | ||
| Q2 24 | $122.7M | $186.7M | ||
| Q1 24 | $98.5M | $210.1M |
| Q4 25 | $52.7M | $-135.0M | ||
| Q3 25 | $52.8M | $15.9M | ||
| Q2 25 | $52.1M | $-64.8M | ||
| Q1 25 | $56.7M | $866.6M | ||
| Q4 24 | $55.9M | $-65.9M | ||
| Q3 24 | $43.9M | $-106.7M | ||
| Q2 24 | $40.8M | $-99.2M | ||
| Q1 24 | $23.3M | $-91.6M |
| Q4 25 | 82.9% | — | ||
| Q3 25 | 84.7% | — | ||
| Q2 25 | 85.9% | — | ||
| Q1 25 | 87.3% | — | ||
| Q4 24 | 84.7% | — | ||
| Q3 24 | 85.0% | — | ||
| Q2 24 | 87.4% | — | ||
| Q1 24 | 87.3% | — |
| Q4 25 | 40.5% | -43.3% | ||
| Q3 25 | 44.7% | 1.4% | ||
| Q2 25 | 45.2% | -19.5% | ||
| Q1 25 | 44.8% | 82.5% | ||
| Q4 24 | 44.3% | -76.2% | ||
| Q3 24 | 39.6% | -27.7% | ||
| Q2 24 | 44.2% | -21.5% | ||
| Q1 24 | 27.5% | -21.6% |
| Q4 25 | 34.5% | -82.0% | ||
| Q3 25 | 35.6% | 7.5% | ||
| Q2 25 | 35.6% | -36.3% | ||
| Q1 25 | 40.1% | 73.7% | ||
| Q4 24 | 39.4% | -30.9% | ||
| Q3 24 | 34.1% | -54.2% | ||
| Q2 24 | 33.2% | -53.1% | ||
| Q1 24 | 23.6% | -43.6% |
| Q4 25 | $0.40 | $-1.63 | ||
| Q3 25 | $0.42 | $0.20 | ||
| Q2 25 | $0.41 | $-0.83 | ||
| Q1 25 | $0.45 | $10.04 | ||
| Q4 24 | $0.44 | $-0.85 | ||
| Q3 24 | $0.35 | $-1.39 | ||
| Q2 24 | $0.33 | $-1.29 | ||
| Q1 24 | $0.19 | $-1.20 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $709.2M | $1.9B |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $954.3M | $-205.3M |
| Total Assets | $1.1B | $2.9B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $709.2M | $1.9B | ||
| Q3 25 | $689.9M | $1.7B | ||
| Q2 25 | $652.8M | $2.0B | ||
| Q1 25 | $580.7M | $2.0B | ||
| Q4 24 | $517.6M | $1.1B | ||
| Q3 24 | $442.3M | $1.0B | ||
| Q2 24 | $375.7M | $1.1B | ||
| Q1 24 | $310.4M | $884.8M |
| Q4 25 | $954.3M | $-205.3M | ||
| Q3 25 | $920.2M | $-155.8M | ||
| Q2 25 | $856.0M | $-206.5M | ||
| Q1 25 | $794.3M | $-185.8M | ||
| Q4 24 | $727.6M | $-1.1B | ||
| Q3 24 | $660.9M | $-1.1B | ||
| Q2 24 | $608.7M | $-980.2M | ||
| Q1 24 | $561.4M | $-893.9M |
| Q4 25 | $1.1B | $2.9B | ||
| Q3 25 | $1.1B | $2.6B | ||
| Q2 25 | $971.9M | $2.6B | ||
| Q1 25 | $908.9M | $2.7B | ||
| Q4 24 | $851.4M | $1.7B | ||
| Q3 24 | $772.0M | $1.8B | ||
| Q2 24 | $706.4M | $1.9B | ||
| Q1 24 | $646.7M | $1.8B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $44.9M | $-34.3M |
| Free Cash FlowOCF − Capex | $44.9M | $-36.6M |
| FCF MarginFCF / Revenue | 29.4% | -22.3% |
| Capex IntensityCapex / Revenue | 0.0% | 1.4% |
| Cash ConversionOCF / Net Profit | 0.85× | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $702.3M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $44.9M | $-34.3M | ||
| Q3 25 | $32.4M | $-66.3M | ||
| Q2 25 | $71.3M | $-58.3M | ||
| Q1 25 | $60.0M | $870.1M | ||
| Q4 24 | $70.9M | $-30.0M | ||
| Q3 24 | $72.9M | $-77.0M | ||
| Q2 24 | $64.1M | $-71.5M | ||
| Q1 24 | $31.9M | $70.8M |
| Q4 25 | $44.9M | $-36.6M | ||
| Q3 25 | — | $-69.7M | ||
| Q2 25 | $71.3M | $-59.6M | ||
| Q1 25 | — | $868.4M | ||
| Q4 24 | $70.8M | $-33.8M | ||
| Q3 24 | $72.6M | $-77.5M | ||
| Q2 24 | $64.1M | $-78.8M | ||
| Q1 24 | $31.7M | $61.2M |
| Q4 25 | 29.4% | -22.3% | ||
| Q3 25 | — | -33.1% | ||
| Q2 25 | 48.6% | -33.3% | ||
| Q1 25 | — | 73.8% | ||
| Q4 24 | 49.9% | -15.8% | ||
| Q3 24 | 56.4% | -39.4% | ||
| Q2 24 | 52.3% | -42.2% | ||
| Q1 24 | 32.2% | 29.1% |
| Q4 25 | 0.0% | 1.4% | ||
| Q3 25 | 0.0% | 1.6% | ||
| Q2 25 | 0.0% | 0.7% | ||
| Q1 25 | 0.0% | 0.1% | ||
| Q4 24 | 0.1% | 1.8% | ||
| Q3 24 | 0.2% | 0.3% | ||
| Q2 24 | 0.0% | 4.0% | ||
| Q1 24 | 0.2% | 4.6% |
| Q4 25 | 0.85× | — | ||
| Q3 25 | 0.61× | -4.17× | ||
| Q2 25 | 1.37× | — | ||
| Q1 25 | 1.06× | 1.00× | ||
| Q4 24 | 1.27× | — | ||
| Q3 24 | 1.66× | — | ||
| Q2 24 | 1.57× | — | ||
| Q1 24 | 1.37× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CPRX
| Firdapse | $97.6M | 64% |
| Agamree | $35.3M | 23% |
| Fycompa | $19.6M | 13% |
PTCT
Segment breakdown not available.
