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Side-by-side financial comparison of CASTLE BIOSCIENCES INC (CSTL) and HEALTHSTREAM INC (HSTM). Click either name above to swap in a different company.

CASTLE BIOSCIENCES INC is the larger business by last-quarter revenue ($87.0M vs $79.7M, roughly 1.1× HEALTHSTREAM INC). On growth, HEALTHSTREAM INC posted the faster year-over-year revenue change (7.4% vs 0.8%). CASTLE BIOSCIENCES INC produced more free cash flow last quarter ($19.7M vs $13.0M). Over the past eight quarters, CASTLE BIOSCIENCES INC's revenue compounded faster (9.2% CAGR vs 4.7%).

Castle Biosciences Inc. is a commercial-stage diagnostic firm that develops and markets proprietary, clinically actionable tests for dermatological conditions such as melanoma and other skin cancers, plus rare diseases. It operates mainly in the U.S. healthcare market, focusing on segments with high unmet need for more accurate diagnostics to guide treatment choices.

HealthStream Inc is a leading U.S.-based provider of workforce development, compliance, and training solutions tailored for the healthcare industry. It offers cloud-based platforms covering clinical skill training, talent management, patient safety education, and regulatory adherence tools, serving over 4,000 healthcare organizations including hospitals, clinics, and long-term care facilities nationwide.

CSTL vs HSTM — Head-to-Head

Bigger by revenue
CSTL
CSTL
1.1× larger
CSTL
$87.0M
$79.7M
HSTM
Growing faster (revenue YoY)
HSTM
HSTM
+6.6% gap
HSTM
7.4%
0.8%
CSTL
More free cash flow
CSTL
CSTL
$6.8M more FCF
CSTL
$19.7M
$13.0M
HSTM
Faster 2-yr revenue CAGR
CSTL
CSTL
Annualised
CSTL
9.2%
4.7%
HSTM

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
CSTL
CSTL
HSTM
HSTM
Revenue
$87.0M
$79.7M
Net Profit
Gross Margin
79.0%
Operating Margin
-4.4%
3.0%
Net Margin
Revenue YoY
0.8%
7.4%
Net Profit YoY
EPS (diluted)
$-0.06
$0.09

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
CSTL
CSTL
HSTM
HSTM
Q4 25
$87.0M
$79.7M
Q3 25
$83.0M
$76.5M
Q2 25
$86.2M
$74.4M
Q1 25
$88.0M
$73.5M
Q4 24
$86.3M
$74.2M
Q3 24
$85.8M
$73.1M
Q2 24
$87.0M
$71.6M
Q1 24
$73.0M
$72.8M
Net Profit
CSTL
CSTL
HSTM
HSTM
Q4 25
Q3 25
$-501.0K
$6.1M
Q2 25
$4.5M
$5.4M
Q1 25
$-25.8M
$4.3M
Q4 24
Q3 24
$2.3M
$5.7M
Q2 24
$8.9M
$4.2M
Q1 24
$-2.5M
$5.2M
Gross Margin
CSTL
CSTL
HSTM
HSTM
Q4 25
79.0%
Q3 25
77.5%
Q2 25
79.5%
Q1 25
81.4%
Q4 24
81.3%
Q3 24
81.8%
Q2 24
83.3%
Q1 24
81.0%
Operating Margin
CSTL
CSTL
HSTM
HSTM
Q4 25
-4.4%
3.0%
Q3 25
-8.2%
9.9%
Q2 25
-4.9%
7.9%
Q1 25
-31.7%
6.0%
Q4 24
4.7%
6.3%
Q3 24
5.9%
8.9%
Q2 24
5.8%
6.2%
Q1 24
-7.5%
7.8%
Net Margin
CSTL
CSTL
HSTM
HSTM
Q4 25
Q3 25
-0.6%
8.0%
Q2 25
5.2%
7.2%
Q1 25
-29.4%
5.9%
Q4 24
Q3 24
2.6%
7.8%
Q2 24
10.3%
5.8%
Q1 24
-3.5%
7.2%
EPS (diluted)
CSTL
CSTL
HSTM
HSTM
Q4 25
$-0.06
$0.09
Q3 25
$-0.02
$0.20
Q2 25
$0.15
$0.18
Q1 25
$-0.90
$0.14
Q4 24
$0.32
$0.16
Q3 24
$0.08
$0.19
Q2 24
$0.31
$0.14
Q1 24
$-0.09
$0.17

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
CSTL
CSTL
HSTM
HSTM
Cash + ST InvestmentsLiquidity on hand
$299.5M
$36.2M
Total DebtLower is stronger
$10.1M
Stockholders' EquityBook value
$470.9M
$354.0M
Total Assets
$578.6M
$520.4M
Debt / EquityLower = less leverage
0.02×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
CSTL
CSTL
HSTM
HSTM
Q4 25
$299.5M
$36.2M
Q3 25
$287.5M
$53.5M
Q2 25
$275.9M
$52.1M
Q1 25
$275.2M
$77.3M
Q4 24
$293.1M
$59.5M
Q3 24
$95.0M
$57.5M
Q2 24
$85.6M
$46.1M
Q1 24
$82.9M
$52.4M
Total Debt
CSTL
CSTL
HSTM
HSTM
Q4 25
$10.1M
Q3 25
$10.0M
Q2 25
$10.0M
Q1 25
$10.0M
Q4 24
$10.0M
Q3 24
$10.0M
Q2 24
$10.0M
Q1 24
$10.0M
Stockholders' Equity
CSTL
CSTL
HSTM
HSTM
Q4 25
$470.9M
$354.0M
Q3 25
$467.0M
$349.2M
Q2 25
$455.4M
$350.6M
Q1 25
$440.3M
$362.8M
Q4 24
$455.8M
$359.4M
Q3 24
$441.1M
$355.5M
Q2 24
$423.9M
$349.2M
Q1 24
$402.5M
$344.9M
Total Assets
CSTL
CSTL
HSTM
HSTM
Q4 25
$578.6M
$520.4M
Q3 25
$562.8M
$499.9M
Q2 25
$544.7M
$500.1M
Q1 25
$501.7M
$524.0M
Q4 24
$531.2M
$510.8M
Q3 24
$514.6M
$502.8M
Q2 24
$487.3M
$499.6M
Q1 24
$458.5M
$511.6M
Debt / Equity
CSTL
CSTL
HSTM
HSTM
Q4 25
0.02×
Q3 25
0.02×
Q2 25
0.02×
Q1 25
0.02×
Q4 24
0.02×
Q3 24
0.02×
Q2 24
0.02×
Q1 24
0.02×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
CSTL
CSTL
HSTM
HSTM
Operating Cash FlowLast quarter
$26.9M
$13.2M
Free Cash FlowOCF − Capex
$19.7M
$13.0M
FCF MarginFCF / Revenue
22.7%
16.3%
Capex IntensityCapex / Revenue
8.3%
0.3%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$28.3M
$59.6M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
CSTL
CSTL
HSTM
HSTM
Q4 25
$26.9M
$13.2M
Q3 25
$22.6M
$18.0M
Q2 25
$20.8M
$5.0M
Q1 25
$-6.0M
$27.1M
Q4 24
$24.4M
$11.2M
Q3 24
$23.3M
$19.1M
Q2 24
$24.0M
$6.5M
Q1 24
$-6.8M
$20.9M
Free Cash Flow
CSTL
CSTL
HSTM
HSTM
Q4 25
$19.7M
$13.0M
Q3 25
$7.8M
$17.9M
Q2 25
$11.6M
$2.7M
Q1 25
$-10.8M
$26.0M
Q4 24
$16.8M
$11.0M
Q3 24
$17.0M
$18.8M
Q2 24
$18.8M
$6.3M
Q1 24
$-16.0M
$20.2M
FCF Margin
CSTL
CSTL
HSTM
HSTM
Q4 25
22.7%
16.3%
Q3 25
9.4%
23.4%
Q2 25
13.4%
3.6%
Q1 25
-12.2%
35.4%
Q4 24
19.5%
14.8%
Q3 24
19.8%
25.8%
Q2 24
21.6%
8.8%
Q1 24
-21.9%
27.8%
Capex Intensity
CSTL
CSTL
HSTM
HSTM
Q4 25
8.3%
0.3%
Q3 25
17.9%
0.1%
Q2 25
10.7%
3.1%
Q1 25
5.4%
1.4%
Q4 24
8.8%
0.3%
Q3 24
7.4%
0.4%
Q2 24
6.0%
0.2%
Q1 24
12.5%
1.0%
Cash Conversion
CSTL
CSTL
HSTM
HSTM
Q4 25
Q3 25
2.96×
Q2 25
4.60×
0.93×
Q1 25
6.25×
Q4 24
Q3 24
10.29×
3.34×
Q2 24
2.69×
1.55×
Q1 24
4.01×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

CSTL
CSTL

Dermatologic$48.6M56%
Non Dermatologic$38.4M44%

HSTM
HSTM

Subscription Services$77.0M97%
Professional Services$2.7M3%

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