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Side-by-side financial comparison of Cue Biopharma, Inc. (CUE) and Esquire Financial Holdings, Inc. (ESQ). Click either name above to swap in a different company.
Esquire Financial Holdings, Inc. is the larger business by last-quarter revenue ($40.5M vs $21.9M, roughly 1.8× Cue Biopharma, Inc.). Esquire Financial Holdings, Inc. runs the higher net margin — 30.2% vs 7.2%, a 23.0% gap on every dollar of revenue. Over the past eight quarters, Cue Biopharma, Inc.'s revenue compounded faster (257.5% CAGR vs 15.0%).
Cue Biopharma is a clinical-stage biotechnology company focused on developing novel targeted immunotherapies for cancer, autoimmune disorders, and inflammatory diseases. Its proprietary platform enables precise T-cell activity modulation, with core operations in North America and global pharma partnerships to advance lead product candidates through clinical trials.
Esquire Financial Holdings, Inc. is a U.S.-headquartered bank holding company that provides comprehensive commercial and consumer banking products and services. Its core offerings include deposit accounts, business loans, mortgage services, and wealth management solutions, primarily serving small to medium enterprises, legal industry professionals, and local retail clients.
CUE vs ESQ — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $21.9M | $40.5M |
| Net Profit | $1.6M | $12.2M |
| Gross Margin | — | — |
| Operating Margin | 9.0% | — |
| Net Margin | 7.2% | 30.2% |
| Revenue YoY | 1292.3% | — |
| Net Profit YoY | 116.7% | 7.0% |
| EPS (diluted) | $0.05 | $1.40 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $40.5M | ||
| Q4 25 | $21.9M | $39.4M | ||
| Q3 25 | $2.1M | $37.6M | ||
| Q2 25 | $3.0M | $35.8M | ||
| Q1 25 | $421.0K | $33.8M | ||
| Q4 24 | $1.6M | $33.1M | ||
| Q3 24 | $3.3M | $31.9M | ||
| Q2 24 | $2.7M | $30.6M |
| Q1 26 | — | $12.2M | ||
| Q4 25 | $1.6M | $13.5M | ||
| Q3 25 | $-7.4M | $14.1M | ||
| Q2 25 | $-8.5M | $11.9M | ||
| Q1 25 | $-12.3M | $11.4M | ||
| Q4 24 | — | $11.8M | ||
| Q3 24 | $-8.7M | $11.4M | ||
| Q2 24 | $-10.2M | $10.5M |
| Q1 26 | — | — | ||
| Q4 25 | 9.0% | 44.3% | ||
| Q3 25 | -353.4% | 46.5% | ||
| Q2 25 | -292.3% | 42.5% | ||
| Q1 25 | -2921.4% | 45.9% | ||
| Q4 24 | — | 47.4% | ||
| Q3 24 | -264.2% | 48.8% | ||
| Q2 24 | -390.6% | 46.9% |
| Q1 26 | — | 30.2% | ||
| Q4 25 | 7.2% | 34.2% | ||
| Q3 25 | -346.6% | 37.4% | ||
| Q2 25 | -287.1% | 33.2% | ||
| Q1 25 | -2911.4% | 33.8% | ||
| Q4 24 | — | 35.6% | ||
| Q3 24 | -259.6% | 35.6% | ||
| Q2 24 | -382.7% | 34.3% |
| Q1 26 | — | $1.40 | ||
| Q4 25 | $0.05 | $1.54 | ||
| Q3 25 | $-0.07 | $1.62 | ||
| Q2 25 | $-0.09 | $1.38 | ||
| Q1 25 | $-0.17 | $1.33 | ||
| Q4 24 | — | $1.35 | ||
| Q3 24 | $-0.17 | $1.34 | ||
| Q2 24 | $-0.20 | $1.25 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $27.1M | $222.2M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $26.4M | $301.3M |
| Total Assets | $42.2M | $2.4B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | $222.2M | ||
| Q4 25 | $27.1M | $235.9M | ||
| Q3 25 | $11.7M | $240.8M | ||
| Q2 25 | $27.5M | $163.0M | ||
| Q1 25 | $13.1M | $173.0M | ||
| Q4 24 | $22.5M | $126.3M | ||
| Q3 24 | $32.4M | $147.7M | ||
| Q2 24 | $30.0M | $152.7M |
| Q1 26 | — | — | ||
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $1.0M | — | ||
| Q2 24 | $2.0M | — |
| Q1 26 | — | $301.3M | ||
| Q4 25 | $26.4M | $289.6M | ||
| Q3 25 | $13.2M | $279.2M | ||
| Q2 25 | $18.2M | $263.6M | ||
| Q1 25 | $6.6M | $250.7M | ||
| Q4 24 | $17.5M | $237.1M | ||
| Q3 24 | $25.4M | $232.6M | ||
| Q2 24 | $21.6M | $217.4M |
| Q1 26 | — | $2.4B | ||
| Q4 25 | $42.2M | $2.4B | ||
| Q3 25 | $31.6M | $2.2B | ||
| Q2 25 | $40.7M | $2.1B | ||
| Q1 25 | $22.3M | $2.0B | ||
| Q4 24 | $32.2M | $1.9B | ||
| Q3 24 | $44.8M | $1.8B | ||
| Q2 24 | $42.3M | $1.7B |
| Q1 26 | — | — | ||
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 0.04× | — | ||
| Q2 24 | 0.09× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-1.1M | — |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | -0.68× | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $-1.1M | $59.8M | ||
| Q3 25 | $-9.0M | $16.8M | ||
| Q2 25 | $-3.4M | $10.5M | ||
| Q1 25 | $-8.2M | $15.8M | ||
| Q4 24 | $-36.3M | $42.2M | ||
| Q3 24 | $-7.5M | $10.5M | ||
| Q2 24 | $-10.0M | $7.2M |
| Q1 26 | — | — | ||
| Q4 25 | — | $56.7M | ||
| Q3 25 | — | $16.2M | ||
| Q2 25 | $-3.4M | $9.3M | ||
| Q1 25 | $-8.3M | $14.7M | ||
| Q4 24 | $-36.4M | $41.5M | ||
| Q3 24 | $-7.5M | $10.5M | ||
| Q2 24 | $-10.0M | $6.9M |
| Q1 26 | — | — | ||
| Q4 25 | — | 143.9% | ||
| Q3 25 | — | 43.2% | ||
| Q2 25 | -116.5% | 26.0% | ||
| Q1 25 | -1976.7% | 43.4% | ||
| Q4 24 | -2309.3% | 125.5% | ||
| Q3 24 | -225.7% | 32.8% | ||
| Q2 24 | -376.2% | 22.5% |
| Q1 26 | — | — | ||
| Q4 25 | 0.0% | 8.0% | ||
| Q3 25 | 0.0% | 1.3% | ||
| Q2 25 | 0.9% | 3.2% | ||
| Q1 25 | 35.6% | 3.4% | ||
| Q4 24 | 4.2% | 2.2% | ||
| Q3 24 | 0.0% | 0.2% | ||
| Q2 24 | 0.4% | 1.1% |
| Q1 26 | — | — | ||
| Q4 25 | -0.68× | 4.44× | ||
| Q3 25 | — | 1.19× | ||
| Q2 25 | — | 0.88× | ||
| Q1 25 | — | 1.39× | ||
| Q4 24 | — | 3.59× | ||
| Q3 24 | — | 0.93× | ||
| Q2 24 | — | 0.69× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CUE
| Immuno Scape Collaboration And License Agreement | $9.5M | 43% |
| BI Collaboration And License Agreement | $8.1M | 37% |
| Other | $4.3M | 20% |
ESQ
| Net Interest Income | $34.0M | 84% |
| Noninterest Income | $6.5M | 16% |
