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Side-by-side financial comparison of Cue Biopharma, Inc. (CUE) and NexPoint Real Estate Finance, Inc. (NREF). Click either name above to swap in a different company.
Cue Biopharma, Inc. is the larger business by last-quarter revenue ($21.9M vs $11.1M, roughly 2.0× NexPoint Real Estate Finance, Inc.). NexPoint Real Estate Finance, Inc. runs the higher net margin — 216.6% vs 7.2%, a 209.4% gap on every dollar of revenue. On growth, Cue Biopharma, Inc. posted the faster year-over-year revenue change (1292.3% vs -48.8%).
Cue Biopharma is a clinical-stage biotechnology company focused on developing novel targeted immunotherapies for cancer, autoimmune disorders, and inflammatory diseases. Its proprietary platform enables precise T-cell activity modulation, with core operations in North America and global pharma partnerships to advance lead product candidates through clinical trials.
NexPoint Real Estate Finance, Inc. is a US-based commercial real estate finance firm that offers structured financing solutions for multifamily, office, industrial, and hospitality properties. It focuses on originating, managing and servicing a diversified portfolio of mortgage loans and real estate-related investments to deliver stable risk-adjusted returns to stakeholders.
CUE vs NREF — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $21.9M | $11.1M |
| Net Profit | $1.6M | $24.0M |
| Gross Margin | — | — |
| Operating Margin | 9.0% | — |
| Net Margin | 7.2% | 216.6% |
| Revenue YoY | 1292.3% | -48.8% |
| Net Profit YoY | 116.7% | 58.7% |
| EPS (diluted) | $0.05 | $0.47 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $21.9M | $11.1M | ||
| Q3 25 | $2.1M | $12.5M | ||
| Q2 25 | $3.0M | $12.1M | ||
| Q1 25 | $421.0K | $11.5M | ||
| Q4 24 | $1.6M | $21.7M | ||
| Q3 24 | $3.3M | $12.5M | ||
| Q2 24 | $2.7M | $6.7M | ||
| Q1 24 | $1.7M | $-12.8M |
| Q4 25 | $1.6M | $24.0M | ||
| Q3 25 | $-7.4M | $50.9M | ||
| Q2 25 | $-8.5M | $22.3M | ||
| Q1 25 | $-12.3M | $26.0M | ||
| Q4 24 | — | $15.2M | ||
| Q3 24 | $-8.7M | $23.3M | ||
| Q2 24 | $-10.2M | $12.1M | ||
| Q1 24 | $-12.3M | $-14.6M |
| Q4 25 | 9.0% | — | ||
| Q3 25 | -353.4% | — | ||
| Q2 25 | -292.3% | — | ||
| Q1 25 | -2921.4% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | -264.2% | — | ||
| Q2 24 | -390.6% | — | ||
| Q1 24 | -737.8% | — |
| Q4 25 | 7.2% | 216.6% | ||
| Q3 25 | -346.6% | 407.0% | ||
| Q2 25 | -287.1% | 184.5% | ||
| Q1 25 | -2911.4% | 225.6% | ||
| Q4 24 | — | 69.9% | ||
| Q3 24 | -259.6% | 186.4% | ||
| Q2 24 | -382.7% | 179.7% | ||
| Q1 24 | -719.1% | 114.3% |
| Q4 25 | $0.05 | $0.47 | ||
| Q3 25 | $-0.07 | $1.14 | ||
| Q2 25 | $-0.09 | $0.54 | ||
| Q1 25 | $-0.17 | $0.70 | ||
| Q4 24 | — | $0.71 | ||
| Q3 24 | $-0.17 | $0.74 | ||
| Q2 24 | $-0.20 | $0.40 | ||
| Q1 24 | $-0.25 | $-0.83 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $27.1M | $31.1M |
| Total DebtLower is stronger | — | $771.2M |
| Stockholders' EquityBook value | $26.4M | $388.0M |
| Total Assets | $42.2M | $5.3B |
| Debt / EquityLower = less leverage | — | 1.99× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $27.1M | $31.1M | ||
| Q3 25 | $11.7M | $17.9M | ||
| Q2 25 | $27.5M | $9.1M | ||
| Q1 25 | $13.1M | $19.2M | ||
| Q4 24 | $22.5M | $3.9M | ||
| Q3 24 | $32.4M | $34.7M | ||
| Q2 24 | $30.0M | $4.3M | ||
| Q1 24 | $41.0M | $13.5M |
| Q4 25 | — | $771.2M | ||
| Q3 25 | — | $720.9M | ||
| Q2 25 | — | $815.6M | ||
| Q1 25 | — | $831.5M | ||
| Q4 24 | — | $799.3M | ||
| Q3 24 | $1.0M | $815.5M | ||
| Q2 24 | $2.0M | $861.0M | ||
| Q1 24 | $3.0M | $843.3M |
| Q4 25 | $26.4M | $388.0M | ||
| Q3 25 | $13.2M | $375.4M | ||
| Q2 25 | $18.2M | $348.2M | ||
| Q1 25 | $6.6M | $343.7M | ||
| Q4 24 | $17.5M | $336.5M | ||
| Q3 24 | $25.4M | $335.8M | ||
| Q2 24 | $21.6M | $327.5M | ||
| Q1 24 | $30.0M | $327.1M |
| Q4 25 | $42.2M | $5.3B | ||
| Q3 25 | $31.6M | $5.3B | ||
| Q2 25 | $40.7M | $5.4B | ||
| Q1 25 | $22.3M | $5.4B | ||
| Q4 24 | $32.2M | $5.4B | ||
| Q3 24 | $44.8M | $5.7B | ||
| Q2 24 | $42.3M | $6.6B | ||
| Q1 24 | $54.0M | $7.1B |
| Q4 25 | — | 1.99× | ||
| Q3 25 | — | 1.92× | ||
| Q2 25 | — | 2.34× | ||
| Q1 25 | — | 2.42× | ||
| Q4 24 | — | 2.38× | ||
| Q3 24 | 0.04× | 2.43× | ||
| Q2 24 | 0.09× | 2.63× | ||
| Q1 24 | 0.10× | 2.58× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-1.1M | $-4.5M |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | -0.68× | -0.19× |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-1.1M | $-4.5M | ||
| Q3 25 | $-9.0M | $8.1M | ||
| Q2 25 | $-3.4M | $3.3M | ||
| Q1 25 | $-8.2M | $16.0M | ||
| Q4 24 | $-36.3M | $4.4M | ||
| Q3 24 | $-7.5M | $14.7M | ||
| Q2 24 | $-10.0M | $-7.5M | ||
| Q1 24 | $-9.8M | $17.7M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | $-3.4M | — | ||
| Q1 25 | $-8.3M | — | ||
| Q4 24 | $-36.4M | — | ||
| Q3 24 | $-7.5M | — | ||
| Q2 24 | $-10.0M | — | ||
| Q1 24 | $-9.8M | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | -116.5% | — | ||
| Q1 25 | -1976.7% | — | ||
| Q4 24 | -2309.3% | — | ||
| Q3 24 | -225.7% | — | ||
| Q2 24 | -376.2% | — | ||
| Q1 24 | -573.0% | — |
| Q4 25 | 0.0% | — | ||
| Q3 25 | 0.0% | — | ||
| Q2 25 | 0.9% | — | ||
| Q1 25 | 35.6% | — | ||
| Q4 24 | 4.2% | — | ||
| Q3 24 | 0.0% | — | ||
| Q2 24 | 0.4% | — | ||
| Q1 24 | 3.2% | — |
| Q4 25 | -0.68× | -0.19× | ||
| Q3 25 | — | 0.16× | ||
| Q2 25 | — | 0.15× | ||
| Q1 25 | — | 0.62× | ||
| Q4 24 | — | 0.29× | ||
| Q3 24 | — | 0.63× | ||
| Q2 24 | — | -0.62× | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CUE
| Immuno Scape Collaboration And License Agreement | $9.5M | 43% |
| BI Collaboration And License Agreement | $8.1M | 37% |
| Other | $4.3M | 20% |
NREF
Segment breakdown not available.
