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Side-by-side financial comparison of Cryoport, Inc. (CYRX) and Esquire Financial Holdings, Inc. (ESQ). Click either name above to swap in a different company.
Cryoport, Inc. is the larger business by last-quarter revenue ($45.5M vs $40.5M, roughly 1.1× Esquire Financial Holdings, Inc.). Esquire Financial Holdings, Inc. runs the higher net margin — 30.2% vs -17.5%, a 47.7% gap on every dollar of revenue. Over the past eight quarters, Esquire Financial Holdings, Inc.'s revenue compounded faster (15.0% CAGR vs 10.4%).
Cryoport, Inc. is a global provider of specialized temperature-controlled logistics and supply chain solutions focused on the life sciences, biopharmaceutical, and cell and gene therapy sectors. It partners with research institutions, biotech firms, and pharmaceutical manufacturers globally to support the safe transport of sensitive biological materials including clinical trial samples and advanced therapy products.
Esquire Financial Holdings, Inc. is a U.S.-headquartered bank holding company that provides comprehensive commercial and consumer banking products and services. Its core offerings include deposit accounts, business loans, mortgage services, and wealth management solutions, primarily serving small to medium enterprises, legal industry professionals, and local retail clients.
CYRX vs ESQ — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $45.5M | $40.5M |
| Net Profit | $-8.0M | $12.2M |
| Gross Margin | 47.8% | — |
| Operating Margin | -17.0% | — |
| Net Margin | -17.5% | 30.2% |
| Revenue YoY | 9.6% | — |
| Net Profit YoY | 57.4% | 7.0% |
| EPS (diluted) | $-0.19 | $1.40 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $40.5M | ||
| Q4 25 | $45.5M | $39.4M | ||
| Q3 25 | $44.2M | $37.6M | ||
| Q2 25 | $45.5M | $35.8M | ||
| Q1 25 | $41.0M | $33.8M | ||
| Q4 24 | $41.5M | $33.1M | ||
| Q3 24 | $38.3M | $31.9M | ||
| Q2 24 | $39.7M | $30.6M |
| Q1 26 | — | $12.2M | ||
| Q4 25 | $-8.0M | $13.5M | ||
| Q3 25 | $-6.9M | $14.1M | ||
| Q2 25 | $105.2M | $11.9M | ||
| Q1 25 | $-12.0M | $11.4M | ||
| Q4 24 | $-18.7M | $11.8M | ||
| Q3 24 | $805.0K | $11.4M | ||
| Q2 24 | $-78.0M | $10.5M |
| Q1 26 | — | — | ||
| Q4 25 | 47.8% | — | ||
| Q3 25 | 48.2% | — | ||
| Q2 25 | 47.0% | — | ||
| Q1 25 | 45.4% | — | ||
| Q4 24 | 47.0% | — | ||
| Q3 24 | 45.5% | — | ||
| Q2 24 | 44.5% | — |
| Q1 26 | — | — | ||
| Q4 25 | -17.0% | 44.3% | ||
| Q3 25 | -22.5% | 46.5% | ||
| Q2 25 | -21.2% | 42.5% | ||
| Q1 25 | -23.1% | 45.9% | ||
| Q4 24 | -30.7% | 47.4% | ||
| Q3 24 | -34.9% | 48.8% | ||
| Q2 24 | -196.5% | 46.9% |
| Q1 26 | — | 30.2% | ||
| Q4 25 | -17.5% | 34.2% | ||
| Q3 25 | -15.7% | 37.4% | ||
| Q2 25 | 231.4% | 33.2% | ||
| Q1 25 | -29.2% | 33.8% | ||
| Q4 24 | -45.1% | 35.6% | ||
| Q3 24 | 2.1% | 35.6% | ||
| Q2 24 | -196.4% | 34.3% |
| Q1 26 | — | $1.40 | ||
| Q4 25 | $-0.19 | $1.54 | ||
| Q3 25 | $-0.18 | $1.62 | ||
| Q2 25 | $2.05 | $1.38 | ||
| Q1 25 | $-0.28 | $1.33 | ||
| Q4 24 | $-0.42 | $1.35 | ||
| Q3 24 | $-0.02 | $1.34 | ||
| Q2 24 | $-1.62 | $1.25 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $411.2M | $222.2M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $502.6M | $301.3M |
| Total Assets | $765.0M | $2.4B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | $222.2M | ||
| Q4 25 | $411.2M | $235.9M | ||
| Q3 25 | $421.3M | $240.8M | ||
| Q2 25 | $426.0M | $163.0M | ||
| Q1 25 | $244.0M | $173.0M | ||
| Q4 24 | $250.6M | $126.3M | ||
| Q3 24 | $259.4M | $147.7M | ||
| Q2 24 | $414.9M | $152.7M |
| Q1 26 | — | $301.3M | ||
| Q4 25 | $502.6M | $289.6M | ||
| Q3 25 | $513.3M | $279.2M | ||
| Q2 25 | $519.1M | $263.6M | ||
| Q1 25 | $398.8M | $250.7M | ||
| Q4 24 | $401.9M | $237.1M | ||
| Q3 24 | $418.6M | $232.6M | ||
| Q2 24 | $400.1M | $217.4M |
| Q1 26 | — | $2.4B | ||
| Q4 25 | $765.0M | $2.4B | ||
| Q3 25 | $774.3M | $2.2B | ||
| Q2 25 | $773.9M | $2.1B | ||
| Q1 25 | $699.8M | $2.0B | ||
| Q4 24 | $703.5M | $1.9B | ||
| Q3 24 | $701.8M | $1.8B | ||
| Q2 24 | $852.3M | $1.7B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $919.0K | — |
| Free Cash FlowOCF − Capex | $-4.5M | — |
| FCF MarginFCF / Revenue | -10.0% | — |
| Capex IntensityCapex / Revenue | 12.0% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-25.0M | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $919.0K | $59.8M | ||
| Q3 25 | $2.2M | $16.8M | ||
| Q2 25 | $-7.3M | $10.5M | ||
| Q1 25 | $-4.3M | $15.8M | ||
| Q4 24 | $-5.5M | $42.2M | ||
| Q3 24 | $447.0K | $10.5M | ||
| Q2 24 | $-8.0M | $7.2M |
| Q1 26 | — | — | ||
| Q4 25 | $-4.5M | $56.7M | ||
| Q3 25 | $-1.3M | $16.2M | ||
| Q2 25 | $-11.7M | $9.3M | ||
| Q1 25 | $-7.5M | $14.7M | ||
| Q4 24 | $-10.7M | $41.5M | ||
| Q3 24 | $-3.8M | $10.5M | ||
| Q2 24 | $-11.8M | $6.9M |
| Q1 26 | — | — | ||
| Q4 25 | -10.0% | 143.9% | ||
| Q3 25 | -2.9% | 43.2% | ||
| Q2 25 | -25.7% | 26.0% | ||
| Q1 25 | -18.3% | 43.4% | ||
| Q4 24 | -25.8% | 125.5% | ||
| Q3 24 | -9.9% | 32.8% | ||
| Q2 24 | -29.8% | 22.5% |
| Q1 26 | — | — | ||
| Q4 25 | 12.0% | 8.0% | ||
| Q3 25 | 7.8% | 1.3% | ||
| Q2 25 | 9.6% | 3.2% | ||
| Q1 25 | 7.7% | 3.4% | ||
| Q4 24 | 12.6% | 2.2% | ||
| Q3 24 | 11.1% | 0.2% | ||
| Q2 24 | 9.5% | 1.1% |
| Q1 26 | — | — | ||
| Q4 25 | — | 4.44× | ||
| Q3 25 | — | 1.19× | ||
| Q2 25 | -0.07× | 0.88× | ||
| Q1 25 | — | 1.39× | ||
| Q4 24 | — | 3.59× | ||
| Q3 24 | 0.56× | 0.93× | ||
| Q2 24 | — | 0.69× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CYRX
Segment breakdown not available.
ESQ
| Net Interest Income | $34.0M | 84% |
| Noninterest Income | $6.5M | 16% |
