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Side-by-side financial comparison of Esperion Therapeutics, Inc. (ESPR) and Protagonist Therapeutics, Inc (PTGX). Click either name above to swap in a different company.
Protagonist Therapeutics, Inc is the larger business by last-quarter revenue ($170.6M vs $168.4M, roughly 1.0× Esperion Therapeutics, Inc.). On growth, Protagonist Therapeutics, Inc posted the faster year-over-year revenue change (184.4% vs 143.7%).
Esperion Therapeutics, Inc. is a publicly traded American pharmaceutical company focused on the development of bempedoic acid, an orally available small molecule designed to lower elevated levels of LDL-C. The company is headquartered in Ann Arbor, Michigan.
Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing novel peptide-based targeted therapies for unmet medical needs, primarily covering gastrointestinal disorders, inflammatory diseases and rare disease indications. Its lead product candidates target inflammatory bowel disease and other chronic immune-related conditions, with operations spanning global R&D and partnership collaborations.
ESPR vs PTGX — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2024
| Metric | | |
|---|---|---|
| Revenue | $168.4M | $170.6M |
| Net Profit | — | $131.7M |
| Gross Margin | — | — |
| Operating Margin | 50.6% | 74.3% |
| Net Margin | — | 77.2% |
| Revenue YoY | 143.7% | 184.4% |
| Net Profit YoY | — | 381.7% |
| EPS (diluted) | $0.32 | $2.01 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $168.4M | — | ||
| Q3 25 | $87.3M | — | ||
| Q2 25 | $82.4M | — | ||
| Q1 25 | $65.0M | — | ||
| Q4 24 | $69.1M | $170.6M | ||
| Q3 24 | $51.6M | — | ||
| Q2 24 | $73.8M | — | ||
| Q1 24 | $137.7M | $255.0M |
| Q4 25 | — | — | ||
| Q3 25 | $-31.3M | — | ||
| Q2 25 | $-12.7M | — | ||
| Q1 25 | $-40.5M | — | ||
| Q4 24 | — | $131.7M | ||
| Q3 24 | $-29.5M | — | ||
| Q2 24 | $-61.9M | — | ||
| Q1 24 | $61.0M | $207.3M |
| Q4 25 | 50.6% | — | ||
| Q3 25 | -11.4% | — | ||
| Q2 25 | 8.6% | — | ||
| Q1 25 | -34.0% | — | ||
| Q4 24 | -6.4% | 74.3% | ||
| Q3 24 | -31.0% | — | ||
| Q2 24 | 3.5% | — | ||
| Q1 24 | 52.5% | 80.9% |
| Q4 25 | — | — | ||
| Q3 25 | -35.9% | — | ||
| Q2 25 | -15.4% | — | ||
| Q1 25 | -62.2% | — | ||
| Q4 24 | — | 77.2% | ||
| Q3 24 | -57.2% | — | ||
| Q2 24 | -83.9% | — | ||
| Q1 24 | 44.3% | 81.3% |
| Q4 25 | $0.32 | — | ||
| Q3 25 | $-0.16 | — | ||
| Q2 25 | $-0.06 | — | ||
| Q1 25 | $-0.21 | — | ||
| Q4 24 | $-0.14 | $2.01 | ||
| Q3 24 | $-0.15 | — | ||
| Q2 24 | $-0.33 | — | ||
| Q1 24 | $0.34 | $3.26 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $167.9M | $418.9M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $-302.0M | $675.3M |
| Total Assets | $465.9M | $744.7M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $167.9M | — | ||
| Q3 25 | $92.4M | — | ||
| Q2 25 | $86.1M | — | ||
| Q1 25 | $114.6M | — | ||
| Q4 24 | $144.8M | $418.9M | ||
| Q3 24 | $144.7M | — | ||
| Q2 24 | $189.3M | — | ||
| Q1 24 | $226.6M | $322.6M |
| Q4 25 | $-302.0M | — | ||
| Q3 25 | $-451.4M | — | ||
| Q2 25 | $-433.5M | — | ||
| Q1 25 | $-426.2M | — | ||
| Q4 24 | $-388.7M | $675.3M | ||
| Q3 24 | $-370.2M | — | ||
| Q2 24 | $-344.2M | — | ||
| Q1 24 | $-294.3M | $560.4M |
| Q4 25 | $465.9M | — | ||
| Q3 25 | $364.0M | — | ||
| Q2 25 | $347.1M | — | ||
| Q1 25 | $324.0M | — | ||
| Q4 24 | $343.8M | $744.7M | ||
| Q3 24 | $314.1M | — | ||
| Q2 24 | $352.3M | — | ||
| Q1 24 | $373.1M | $629.3M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $45.2M | $184.2M |
| Free Cash FlowOCF − Capex | — | $182.8M |
| FCF MarginFCF / Revenue | — | 107.1% |
| Capex IntensityCapex / Revenue | 0.0% | 0.8% |
| Cash ConversionOCF / Net Profit | — | 1.40× |
| TTM Free Cash FlowTrailing 4 quarters | — | $101.7M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $45.2M | — | ||
| Q3 25 | $-4.3M | — | ||
| Q2 25 | $-31.4M | — | ||
| Q1 25 | $-22.6M | — | ||
| Q4 24 | $-35.0M | $184.2M | ||
| Q3 24 | $-35.3M | — | ||
| Q2 24 | $-7.2M | — | ||
| Q1 24 | $53.8M | $-27.4M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | $182.8M | ||
| Q3 24 | $-35.5M | — | ||
| Q2 24 | $-7.3M | — | ||
| Q1 24 | $53.8M | $-27.7M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 107.1% | ||
| Q3 24 | -68.7% | — | ||
| Q2 24 | -9.9% | — | ||
| Q1 24 | 39.0% | -10.9% |
| Q4 25 | 0.0% | — | ||
| Q3 25 | 0.0% | — | ||
| Q2 25 | 0.0% | — | ||
| Q1 25 | 0.0% | — | ||
| Q4 24 | 0.0% | 0.8% | ||
| Q3 24 | 0.3% | — | ||
| Q2 24 | 0.1% | — | ||
| Q1 24 | 0.1% | 0.1% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 1.40× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | 0.88× | -0.13× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ESPR
| Collaboration Revenue | $124.7M | 74% |
| Products | $43.7M | 26% |
PTGX
Segment breakdown not available.
