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Side-by-side financial comparison of EXELIXIS, INC. (EXEL) and RYAN SPECIALTY HOLDINGS, INC. (RYAN). Click either name above to swap in a different company.
RYAN SPECIALTY HOLDINGS, INC. is the larger business by last-quarter revenue ($738.0M vs $598.7M, roughly 1.2× EXELIXIS, INC.). EXELIXIS, INC. runs the higher net margin — 40.8% vs 1.1%, a 39.8% gap on every dollar of revenue. On growth, RYAN SPECIALTY HOLDINGS, INC. posted the faster year-over-year revenue change (13.6% vs 5.6%). Over the past eight quarters, EXELIXIS, INC.'s revenue compounded faster (18.7% CAGR vs 17.1%).
Exelixis, Inc. is a genomics-based drug discovery company located in Alameda, California, and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer.
Aon plc is a British-American professional services firm. The company operates two divisions: Risk Capital, which provides brokerage and consulting services for risk management and insurance and reinsurance, and Human Capital, which provides services for health insurance, retirement plans, pension plans, and talent advisory.
EXEL vs RYAN — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $598.7M | $738.0M |
| Net Profit | $244.5M | $8.0M |
| Gross Margin | 95.6% | — |
| Operating Margin | 39.3% | 12.4% |
| Net Margin | 40.8% | 1.1% |
| Revenue YoY | 5.6% | 13.6% |
| Net Profit YoY | 74.8% | -42.0% |
| EPS (diluted) | $0.89 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | $598.7M | — | ||
| Q4 25 | $597.8M | $738.0M | ||
| Q3 25 | $568.3M | $739.6M | ||
| Q2 25 | $555.4M | $840.9M | ||
| Q1 25 | $566.8M | $676.1M | ||
| Q4 24 | — | $649.4M | ||
| Q3 24 | $539.5M | $588.1M | ||
| Q2 24 | $637.2M | $680.2M |
| Q1 26 | $244.5M | — | ||
| Q4 25 | $193.6M | $8.0M | ||
| Q3 25 | $184.8M | $31.1M | ||
| Q2 25 | $159.6M | $52.0M | ||
| Q1 25 | $139.9M | $-27.6M | ||
| Q4 24 | — | $13.8M | ||
| Q3 24 | $118.0M | $17.6M | ||
| Q2 24 | $226.1M | $46.8M |
| Q1 26 | 95.6% | — | ||
| Q4 25 | 96.9% | — | ||
| Q3 25 | 96.6% | — | ||
| Q2 25 | 96.5% | — | ||
| Q1 25 | 96.5% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 96.8% | — | ||
| Q2 24 | 97.2% | — |
| Q1 26 | 39.3% | — | ||
| Q4 25 | 39.6% | 12.4% | ||
| Q3 25 | 37.6% | 15.0% | ||
| Q2 25 | 33.6% | 22.7% | ||
| Q1 25 | 28.8% | 14.8% | ||
| Q4 24 | — | 16.8% | ||
| Q3 24 | 25.2% | 13.9% | ||
| Q2 24 | 43.3% | 24.2% |
| Q1 26 | 40.8% | — | ||
| Q4 25 | 32.4% | 1.1% | ||
| Q3 25 | 32.5% | 4.2% | ||
| Q2 25 | 28.7% | 6.2% | ||
| Q1 25 | 24.7% | -4.1% | ||
| Q4 24 | — | 2.1% | ||
| Q3 24 | 21.9% | 3.0% | ||
| Q2 24 | 35.5% | 6.9% |
| Q1 26 | $0.89 | — | ||
| Q4 25 | $0.69 | — | ||
| Q3 25 | $0.65 | — | ||
| Q2 25 | $0.55 | — | ||
| Q1 25 | $0.47 | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $0.40 | — | ||
| Q2 24 | $0.77 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $1.1B | $158.3M |
| Total DebtLower is stronger | — | $3.3B |
| Stockholders' EquityBook value | $2.2B | $648.1M |
| Total Assets | $2.8B | $10.6B |
| Debt / EquityLower = less leverage | — | 5.16× |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | $1.1B | — | ||
| Q4 25 | $988.5M | $158.3M | ||
| Q3 25 | $791.1M | $153.5M | ||
| Q2 25 | $1.0B | $172.6M | ||
| Q1 25 | $1.1B | $203.5M | ||
| Q4 24 | — | $540.2M | ||
| Q3 24 | $1.2B | $235.2M | ||
| Q2 24 | $1.0B | $1.7B |
| Q1 26 | — | — | ||
| Q4 25 | — | $3.3B | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | $3.3B | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — |
| Q1 26 | $2.2B | — | ||
| Q4 25 | $2.2B | $648.1M | ||
| Q3 25 | $2.0B | $630.5M | ||
| Q2 25 | $2.1B | $610.1M | ||
| Q1 25 | $2.2B | $542.5M | ||
| Q4 24 | — | $627.7M | ||
| Q3 24 | $2.3B | $632.8M | ||
| Q2 24 | $2.1B | $605.9M |
| Q1 26 | $2.8B | — | ||
| Q4 25 | $2.8B | $10.6B | ||
| Q3 25 | $2.7B | $9.9B | ||
| Q2 25 | $2.8B | $10.6B | ||
| Q1 25 | $2.9B | $9.9B | ||
| Q4 24 | — | $9.6B | ||
| Q3 24 | $3.0B | $8.5B | ||
| Q2 24 | $2.8B | $8.3B |
| Q1 26 | — | — | ||
| Q4 25 | — | 5.16× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 5.22× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $333.5M | $263.2M |
| Free Cash FlowOCF − Capex | $332.4M | — |
| FCF MarginFCF / Revenue | 55.5% | — |
| Capex IntensityCapex / Revenue | 0.2% | 0.0% |
| Cash ConversionOCF / Net Profit | 1.36× | 32.99× |
| TTM Free Cash FlowTrailing 4 quarters | $875.8M | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | $333.5M | — | ||
| Q4 25 | $290.3M | $263.2M | ||
| Q3 25 | $49.0M | $169.7M | ||
| Q2 25 | $211.4M | $353.6M | ||
| Q1 25 | $240.3M | $-142.8M | ||
| Q4 24 | — | $259.6M | ||
| Q3 24 | $271.3M | $100.9M | ||
| Q2 24 | $119.5M | $270.8M |
| Q1 26 | $332.4M | — | ||
| Q4 25 | $288.8M | — | ||
| Q3 25 | $46.2M | $167.3M | ||
| Q2 25 | $208.5M | — | ||
| Q1 25 | $236.3M | $-143.5M | ||
| Q4 24 | — | — | ||
| Q3 24 | $263.1M | — | ||
| Q2 24 | $113.0M | — |
| Q1 26 | 55.5% | — | ||
| Q4 25 | 48.3% | — | ||
| Q3 25 | 8.1% | 22.6% | ||
| Q2 25 | 37.5% | — | ||
| Q1 25 | 41.7% | -21.2% | ||
| Q4 24 | — | — | ||
| Q3 24 | 48.8% | — | ||
| Q2 24 | 17.7% | — |
| Q1 26 | 0.2% | — | ||
| Q4 25 | 0.2% | 0.0% | ||
| Q3 25 | 0.5% | 0.3% | ||
| Q2 25 | 0.5% | 0.0% | ||
| Q1 25 | 0.7% | 0.1% | ||
| Q4 24 | — | 0.0% | ||
| Q3 24 | 1.5% | 0.0% | ||
| Q2 24 | 1.0% | 0.0% |
| Q1 26 | 1.36× | — | ||
| Q4 25 | 1.50× | 32.99× | ||
| Q3 25 | 0.27× | 5.46× | ||
| Q2 25 | 1.32× | 6.80× | ||
| Q1 25 | 1.72× | — | ||
| Q4 24 | — | 18.88× | ||
| Q3 24 | 2.30× | 5.74× | ||
| Q2 24 | 0.53× | 5.79× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
EXEL
| Cabometyx | $544.7M | 91% |
| Collaboration | $52.1M | 9% |
| Collaborative Arrangementwith Takeda | $5.9M | 1% |
| Cometriq | $1.8M | 0% |
RYAN
| Wholesale Brokerage | $385.7M | 52% |
| Underwriting Management | $268.3M | 36% |
| Binding Authorities | $84.0M | 11% |
