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Side-by-side financial comparison of Guardant Health, Inc. (GH) and OSI SYSTEMS INC (OSIS). Click either name above to swap in a different company.
OSI SYSTEMS INC is the larger business by last-quarter revenue ($464.1M vs $281.3M, roughly 1.6× Guardant Health, Inc.). OSI SYSTEMS INC runs the higher net margin — 8.3% vs -45.7%, a 54.0% gap on every dollar of revenue. On growth, Guardant Health, Inc. posted the faster year-over-year revenue change (39.4% vs 10.5%). OSI SYSTEMS INC produced more free cash flow last quarter ($55.5M vs $-54.2M). Over the past eight quarters, Guardant Health, Inc.'s revenue compounded faster (29.2% CAGR vs 7.0%).
Guardant Health, Inc. is an American biotechnology company based in Palo Alto, California. Co-founders Helmy Eltoukhy and AmirAli Talasaz serve as co-chief executive officers.
OSI Systems, Inc. is an American company based in California that develops and markets security and inspection systems such as airport security X-ray machines and metal detectors, medical monitoring and anesthesia systems, and optoelectronic devices. As of June 2010, the company employs approximately 3,180 personnel globally and includes subsidiary companies Spacelabs Healthcare, Rapiscan Systems and OSI Optoelectronics.
GH vs OSIS — Head-to-Head
Income Statement — Q4 FY2025 vs Q2 FY2026
| Metric | | |
|---|---|---|
| Revenue | $281.3M | $464.1M |
| Net Profit | $-128.5M | $38.7M |
| Gross Margin | 64.6% | 32.7% |
| Operating Margin | -43.0% | 12.7% |
| Net Margin | -45.7% | 8.3% |
| Revenue YoY | 39.4% | 10.5% |
| Net Profit YoY | -15.8% | 2.3% |
| EPS (diluted) | $-1.01 | $2.22 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $281.3M | $464.1M | ||
| Q3 25 | $265.2M | $384.6M | ||
| Q2 25 | $232.1M | $505.0M | ||
| Q1 25 | $203.5M | $444.4M | ||
| Q4 24 | $201.8M | $419.8M | ||
| Q3 24 | $191.5M | $344.0M | ||
| Q2 24 | $177.2M | $480.9M | ||
| Q1 24 | $168.5M | $405.4M |
| Q4 25 | $-128.5M | $38.7M | ||
| Q3 25 | $-92.7M | $20.6M | ||
| Q2 25 | $-99.9M | $52.7M | ||
| Q1 25 | $-95.2M | $41.1M | ||
| Q4 24 | $-111.0M | $37.8M | ||
| Q3 24 | $-107.8M | $17.9M | ||
| Q2 24 | $-102.6M | $44.7M | ||
| Q1 24 | $-115.0M | $34.0M |
| Q4 25 | 64.6% | 32.7% | ||
| Q3 25 | 64.7% | 32.0% | ||
| Q2 25 | 65.0% | 33.3% | ||
| Q1 25 | 63.3% | 33.8% | ||
| Q4 24 | 61.6% | 35.1% | ||
| Q3 24 | 61.1% | 35.3% | ||
| Q2 24 | 59.1% | 32.1% | ||
| Q1 24 | 61.2% | 33.6% |
| Q4 25 | -43.0% | 12.7% | ||
| Q3 25 | -37.3% | 8.6% | ||
| Q2 25 | -45.9% | 14.5% | ||
| Q1 25 | -54.6% | 12.7% | ||
| Q4 24 | -62.4% | 13.8% | ||
| Q3 24 | -61.3% | 8.8% | ||
| Q2 24 | -56.8% | 13.1% | ||
| Q1 24 | -59.2% | 12.7% |
| Q4 25 | -45.7% | 8.3% | ||
| Q3 25 | -35.0% | 5.3% | ||
| Q2 25 | -43.0% | 10.4% | ||
| Q1 25 | -46.8% | 9.3% | ||
| Q4 24 | -55.0% | 9.0% | ||
| Q3 24 | -56.3% | 5.2% | ||
| Q2 24 | -57.9% | 9.3% | ||
| Q1 24 | -68.2% | 8.4% |
| Q4 25 | $-1.01 | $2.22 | ||
| Q3 25 | $-0.74 | $1.18 | ||
| Q2 25 | $-0.80 | $3.04 | ||
| Q1 25 | $-0.77 | $2.40 | ||
| Q4 24 | $-0.90 | $2.22 | ||
| Q3 24 | $-0.88 | $1.05 | ||
| Q2 24 | $-0.84 | $2.57 | ||
| Q1 24 | $-0.94 | $1.95 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $378.2M | $336.7M |
| Total DebtLower is stronger | $1.5B | $1.0B |
| Stockholders' EquityBook value | $-99.3M | $845.5M |
| Total Assets | $2.0B | $2.5B |
| Debt / EquityLower = less leverage | — | 1.19× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $378.2M | $336.7M | ||
| Q3 25 | $580.0M | $124.4M | ||
| Q2 25 | $629.1M | $106.4M | ||
| Q1 25 | $698.6M | $95.8M | ||
| Q4 24 | $525.5M | $101.6M | ||
| Q3 24 | $585.0M | $85.1M | ||
| Q2 24 | $933.7M | $95.4M | ||
| Q1 24 | $1.0B | $101.4M |
| Q4 25 | $1.5B | $1.0B | ||
| Q3 25 | $1.1B | $442.2M | ||
| Q2 25 | $1.1B | $471.6M | ||
| Q1 25 | $1.1B | $473.2M | ||
| Q4 24 | $1.1B | $474.8M | ||
| Q3 24 | — | $476.3M | ||
| Q2 24 | — | $137.6M | ||
| Q1 24 | — | — |
| Q4 25 | $-99.3M | $845.5M | ||
| Q3 25 | $-354.5M | $946.0M | ||
| Q2 25 | $-305.5M | $951.1M | ||
| Q1 25 | $-250.8M | $879.3M | ||
| Q4 24 | $-139.6M | $825.8M | ||
| Q3 24 | $-60.1M | $786.5M | ||
| Q2 24 | $-1.6M | $863.5M | ||
| Q1 24 | $68.3M | $813.4M |
| Q4 25 | $2.0B | $2.5B | ||
| Q3 25 | $1.3B | $2.3B | ||
| Q2 25 | $1.3B | $2.2B | ||
| Q1 25 | $1.3B | $2.1B | ||
| Q4 24 | $1.5B | $2.1B | ||
| Q3 24 | $1.5B | $2.1B | ||
| Q2 24 | $1.6B | $1.9B | ||
| Q1 24 | $1.7B | $1.8B |
| Q4 25 | — | 1.19× | ||
| Q3 25 | — | 0.47× | ||
| Q2 25 | — | 0.50× | ||
| Q1 25 | — | 0.54× | ||
| Q4 24 | — | 0.57× | ||
| Q3 24 | — | 0.61× | ||
| Q2 24 | — | 0.16× | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-26.4M | $62.2M |
| Free Cash FlowOCF − Capex | $-54.2M | $55.5M |
| FCF MarginFCF / Revenue | -19.3% | 12.0% |
| Capex IntensityCapex / Revenue | 9.9% | 1.4% |
| Cash ConversionOCF / Net Profit | — | 1.61× |
| TTM Free Cash FlowTrailing 4 quarters | $-233.1M | $137.2M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-26.4M | $62.2M | ||
| Q3 25 | $-35.4M | $17.1M | ||
| Q2 25 | $-60.3M | $562.0K | ||
| Q1 25 | $-62.7M | $81.6M | ||
| Q4 24 | $-64.5M | $52.5M | ||
| Q3 24 | $-51.1M | $-37.2M | ||
| Q2 24 | $-94.0M | $-29.0M | ||
| Q1 24 | $-30.3M | $-52.1M |
| Q4 25 | $-54.2M | $55.5M | ||
| Q3 25 | $-45.8M | $10.1M | ||
| Q2 25 | $-65.9M | $-5.6M | ||
| Q1 25 | $-67.1M | $77.1M | ||
| Q4 24 | $-83.4M | $47.1M | ||
| Q3 24 | $-55.3M | $-44.9M | ||
| Q2 24 | $-99.1M | $-37.5M | ||
| Q1 24 | $-37.2M | $-57.0M |
| Q4 25 | -19.3% | 12.0% | ||
| Q3 25 | -17.3% | 2.6% | ||
| Q2 25 | -28.4% | -1.1% | ||
| Q1 25 | -33.0% | 17.4% | ||
| Q4 24 | -41.3% | 11.2% | ||
| Q3 24 | -28.9% | -13.0% | ||
| Q2 24 | -55.9% | -7.8% | ||
| Q1 24 | -22.1% | -14.1% |
| Q4 25 | 9.9% | 1.4% | ||
| Q3 25 | 3.9% | 1.8% | ||
| Q2 25 | 2.4% | 1.2% | ||
| Q1 25 | 2.2% | 1.0% | ||
| Q4 24 | 9.4% | 1.3% | ||
| Q3 24 | 2.2% | 2.2% | ||
| Q2 24 | 2.9% | 1.8% | ||
| Q1 24 | 4.1% | 1.2% |
| Q4 25 | — | 1.61× | ||
| Q3 25 | — | 0.83× | ||
| Q2 25 | — | 0.01× | ||
| Q1 25 | — | 1.98× | ||
| Q4 24 | — | 1.39× | ||
| Q3 24 | — | -2.07× | ||
| Q2 24 | — | -0.65× | ||
| Q1 24 | — | -1.53× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
GH
| Oncology | $189.9M | 68% |
| Biopharma Data | $54.0M | 19% |
| Screening | $35.1M | 12% |
| Licensing Other | $2.2M | 1% |
OSIS
| Security Division | $334.7M | 72% |
| Optoelectronics And Manufacturing Division | $92.8M | 20% |
| Healthcare Division | $36.5M | 8% |
