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Side-by-side financial comparison of Health Catalyst, Inc. (HCAT) and Twist Bioscience Corp (TWST). Click either name above to swap in a different company.
Twist Bioscience Corp is the larger business by last-quarter revenue ($103.7M vs $74.7M, roughly 1.4× Health Catalyst, Inc.). Twist Bioscience Corp runs the higher net margin — -29.4% vs -121.9%, a 92.5% gap on every dollar of revenue. On growth, Twist Bioscience Corp posted the faster year-over-year revenue change (16.9% vs -6.2%). Health Catalyst, Inc. produced more free cash flow last quarter ($9.6M vs $-34.8M).
Catalyst Pharmaceuticals, Inc. is a biopharmaceutical company based in Coral Gables, Florida, United States. The company develops medicines for rare diseases, including the phosphate salt of amifampridine for the treatment of Lambert–Eaton myasthenic syndrome (LEMS). The drug is referred to under the trade name Firdapse, which was approved by the FDA for approved use in children 6 years and older with LEMS in addition to the prior approval for use in adults with LEMS on November 28, 2018. Fir...
Twist Bioscience is a public biotechnology company based in South San Francisco that manufactures synthetic DNA and DNA products for customers in a wide range of industries. Twist was founded in 2013 by Emily Leproust, Bill Banyai, and Bill Peck.
HCAT vs TWST — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $74.7M | $103.7M |
| Net Profit | $-91.0M | $-30.5M |
| Gross Margin | — | 52.0% |
| Operating Margin | -115.3% | -31.7% |
| Net Margin | -121.9% | -29.4% |
| Revenue YoY | -6.2% | 16.9% |
| Net Profit YoY | -340.3% | 3.4% |
| EPS (diluted) | $-1.29 | $-0.50 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $74.7M | $103.7M | ||
| Q3 25 | $76.3M | — | ||
| Q2 25 | $80.7M | — | ||
| Q1 25 | $79.4M | — | ||
| Q4 24 | $79.6M | — | ||
| Q3 24 | $76.4M | — | ||
| Q2 24 | $75.9M | — | ||
| Q1 24 | $74.7M | — |
| Q4 25 | $-91.0M | $-30.5M | ||
| Q3 25 | $-22.2M | — | ||
| Q2 25 | $-41.0M | — | ||
| Q1 25 | $-23.7M | — | ||
| Q4 24 | $-20.7M | — | ||
| Q3 24 | $-14.7M | — | ||
| Q2 24 | $-13.5M | — | ||
| Q1 24 | $-20.6M | — |
| Q4 25 | — | 52.0% | ||
| Q3 25 | 52.6% | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 47.5% | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | -115.3% | -31.7% | ||
| Q3 25 | -22.9% | — | ||
| Q2 25 | -46.0% | — | ||
| Q1 25 | -25.4% | — | ||
| Q4 24 | -22.0% | — | ||
| Q3 24 | -17.9% | — | ||
| Q2 24 | -20.8% | — | ||
| Q1 24 | -30.5% | — |
| Q4 25 | -121.9% | -29.4% | ||
| Q3 25 | -29.1% | — | ||
| Q2 25 | -50.8% | — | ||
| Q1 25 | -29.9% | — | ||
| Q4 24 | -26.0% | — | ||
| Q3 24 | -19.3% | — | ||
| Q2 24 | -17.8% | — | ||
| Q1 24 | -27.6% | — |
| Q4 25 | $-1.29 | $-0.50 | ||
| Q3 25 | $-0.32 | — | ||
| Q2 25 | $-0.59 | — | ||
| Q1 25 | $-0.35 | — | ||
| Q4 24 | $-0.33 | — | ||
| Q3 24 | $-0.24 | — | ||
| Q2 24 | $-0.23 | — | ||
| Q1 24 | $-0.35 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $95.7M | $197.9M |
| Total DebtLower is stronger | $153.3M | — |
| Stockholders' EquityBook value | $245.8M | $456.1M |
| Total Assets | $502.6M | $638.1M |
| Debt / EquityLower = less leverage | 0.62× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $95.7M | $197.9M | ||
| Q3 25 | $91.5M | — | ||
| Q2 25 | $97.3M | — | ||
| Q1 25 | $342.0M | — | ||
| Q4 24 | $392.0M | — | ||
| Q3 24 | $387.3M | — | ||
| Q2 24 | $308.3M | — | ||
| Q1 24 | $327.8M | — |
| Q4 25 | $153.3M | — | ||
| Q3 25 | $153.1M | — | ||
| Q2 25 | $153.0M | — | ||
| Q1 25 | $382.9M | — | ||
| Q4 24 | $382.4M | — | ||
| Q3 24 | $345.0M | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $245.8M | $456.1M | ||
| Q3 25 | $331.9M | — | ||
| Q2 25 | $347.5M | — | ||
| Q1 25 | $376.8M | — | ||
| Q4 24 | $365.2M | — | ||
| Q3 24 | $355.0M | — | ||
| Q2 24 | $357.0M | — | ||
| Q1 24 | $357.2M | — |
| Q4 25 | $502.6M | $638.1M | ||
| Q3 25 | $587.1M | — | ||
| Q2 25 | $616.2M | — | ||
| Q1 25 | $891.5M | — | ||
| Q4 24 | $858.9M | — | ||
| Q3 24 | $813.0M | — | ||
| Q2 24 | $691.7M | — | ||
| Q1 24 | $695.1M | — |
| Q4 25 | 0.62× | — | ||
| Q3 25 | 0.46× | — | ||
| Q2 25 | 0.44× | — | ||
| Q1 25 | 1.02× | — | ||
| Q4 24 | 1.05× | — | ||
| Q3 24 | 0.97× | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $9.9M | $-24.8M |
| Free Cash FlowOCF − Capex | $9.6M | $-34.8M |
| FCF MarginFCF / Revenue | 12.9% | -33.5% |
| Capex IntensityCapex / Revenue | 0.4% | 9.6% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-697.0K | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $9.9M | $-24.8M | ||
| Q3 25 | $-464.0K | — | ||
| Q2 25 | $-9.0M | — | ||
| Q1 25 | $280.0K | — | ||
| Q4 24 | $-3.5M | — | ||
| Q3 24 | $6.2M | — | ||
| Q2 24 | $1.6M | — | ||
| Q1 24 | $10.3M | — |
| Q4 25 | $9.6M | $-34.8M | ||
| Q3 25 | $-719.0K | — | ||
| Q2 25 | $-9.2M | — | ||
| Q1 25 | $-390.0K | — | ||
| Q4 24 | $-3.9M | — | ||
| Q3 24 | $5.5M | — | ||
| Q2 24 | $1.3M | — | ||
| Q1 24 | $10.1M | — |
| Q4 25 | 12.9% | -33.5% | ||
| Q3 25 | -0.9% | — | ||
| Q2 25 | -11.4% | — | ||
| Q1 25 | -0.5% | — | ||
| Q4 24 | -4.9% | — | ||
| Q3 24 | 7.2% | — | ||
| Q2 24 | 1.7% | — | ||
| Q1 24 | 13.5% | — |
| Q4 25 | 0.4% | 9.6% | ||
| Q3 25 | 0.3% | — | ||
| Q2 25 | 0.3% | — | ||
| Q1 25 | 0.8% | — | ||
| Q4 24 | 0.5% | — | ||
| Q3 24 | 0.9% | — | ||
| Q2 24 | 0.4% | — | ||
| Q1 24 | 0.3% | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
HCAT
| Recurring Technology | $51.9M | 69% |
| Professional Services | $22.8M | 31% |
TWST
| Industrial Chemicals | $37.2M | 36% |
| Diagnostics | $35.3M | 34% |
| Food Or Agriculture | $12.8M | 12% |
| Academic Research | $12.2M | 12% |
| Health Care | $6.1M | 6% |
