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Side-by-side financial comparison of HERON THERAPEUTICS, INC. (HRTX) and STEM, INC. (STEM). Click either name above to swap in a different company.
STEM, INC. is the larger business by last-quarter revenue ($47.1M vs $40.6M, roughly 1.2× HERON THERAPEUTICS, INC.). HERON THERAPEUTICS, INC. runs the higher net margin — -7.3% vs -33.9%, a 26.6% gap on every dollar of revenue. On growth, HERON THERAPEUTICS, INC. posted the faster year-over-year revenue change (-0.5% vs -15.6%). Over the past eight quarters, STEM, INC.'s revenue compounded faster (36.1% CAGR vs 8.2%).
Antibe Therapeutics was a Toronto-based pharmaceutical company that develops pain and inflammation-reducing drugs based on gaseous mediator technology. Antibe was founded by John L. Wallace, also a co-founder of NicOx, the first company to develop drugs utilizing gaseous mediators. Founded in 2009, the company listed on the TSX Venture Exchange in 2013 and was moved to the Toronto Stock Exchange in November 2020. In 2015, Antibe acquired Citagenix, a distributor involved in regenerative medic...
StemCells, Inc. is a public biopharmaceutical company headquartered in Newark, California, that is developing purified human neural stem cells (HuCNS-SCs) in the hopes of treating central nervous system disorders and paralysis. StemCells' HuCNS-SCs have the ability to differentiate into the three main types of cells found in the central nervous system: neurons, astrocytes and oligodendrocytes.
HRTX vs STEM — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $40.6M | $47.1M |
| Net Profit | $-3.0M | $-16.0M |
| Gross Margin | 72.6% | 48.9% |
| Operating Margin | 0.1% | -17.7% |
| Net Margin | -7.3% | -33.9% |
| Revenue YoY | -0.5% | -15.6% |
| Net Profit YoY | -180.6% | 68.8% |
| EPS (diluted) | $-0.01 | $-4.40 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $40.6M | $47.1M | ||
| Q3 25 | $38.2M | $38.2M | ||
| Q2 25 | $37.2M | $38.4M | ||
| Q1 25 | $38.9M | $32.5M | ||
| Q4 24 | $40.8M | $55.8M | ||
| Q3 24 | $32.8M | $29.3M | ||
| Q2 24 | $36.0M | $34.0M | ||
| Q1 24 | $34.7M | $25.5M |
| Q4 25 | $-3.0M | $-16.0M | ||
| Q3 25 | $-17.5M | $-23.8M | ||
| Q2 25 | $-2.4M | $202.5M | ||
| Q1 25 | $2.6M | $-25.0M | ||
| Q4 24 | $3.7M | $-51.1M | ||
| Q3 24 | $-4.8M | $-148.3M | ||
| Q2 24 | $-9.2M | $-582.3M | ||
| Q1 24 | $-3.2M | $-72.3M |
| Q4 25 | 72.6% | 48.9% | ||
| Q3 25 | 68.8% | 35.5% | ||
| Q2 25 | 73.5% | 33.4% | ||
| Q1 25 | 78.3% | 32.4% | ||
| Q4 24 | 74.9% | -4.4% | ||
| Q3 24 | 71.2% | 21.2% | ||
| Q2 24 | 70.8% | 27.6% | ||
| Q1 24 | 75.6% | -95.0% |
| Q4 25 | 0.1% | -17.7% | ||
| Q3 25 | -10.7% | -33.6% | ||
| Q2 25 | -4.4% | -34.8% | ||
| Q1 25 | 8.1% | -65.0% | ||
| Q4 24 | 10.2% | -84.4% | ||
| Q3 24 | -13.6% | -493.2% | ||
| Q2 24 | -17.9% | -1705.5% | ||
| Q1 24 | -13.8% | -267.0% |
| Q4 25 | -7.3% | -33.9% | ||
| Q3 25 | -45.8% | -62.2% | ||
| Q2 25 | -6.4% | 527.8% | ||
| Q1 25 | 6.8% | -76.9% | ||
| Q4 24 | 9.0% | -91.6% | ||
| Q3 24 | -14.8% | -506.3% | ||
| Q2 24 | -25.6% | -1712.6% | ||
| Q1 24 | -9.1% | -283.9% |
| Q4 25 | $-0.01 | $-4.40 | ||
| Q3 25 | $-0.10 | $-2.84 | ||
| Q2 25 | $-0.02 | $-1.79 | ||
| Q1 25 | $0.01 | $-0.15 | ||
| Q4 24 | $0.02 | $-15.29 | ||
| Q3 24 | $-0.03 | $-18.24 | ||
| Q2 24 | $-0.06 | $-71.81 | ||
| Q1 24 | $-0.02 | $-0.46 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $28.6M | $48.9M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $14.3M | $-249.4M |
| Total Assets | $255.9M | $308.9M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $28.6M | $48.9M | ||
| Q3 25 | $43.1M | $43.1M | ||
| Q2 25 | $16.5M | $40.8M | ||
| Q1 25 | $19.3M | $58.6M | ||
| Q4 24 | $25.8M | $56.3M | ||
| Q3 24 | $25.7M | $75.4M | ||
| Q2 24 | $18.4M | $89.6M | ||
| Q1 24 | $20.4M | $112.8M |
| Q4 25 | $14.3M | $-249.4M | ||
| Q3 25 | $14.9M | $-235.7M | ||
| Q2 25 | $-27.3M | $-214.1M | ||
| Q1 25 | $-28.5M | $-417.5M | ||
| Q4 24 | $-33.7M | $-398.4M | ||
| Q3 24 | $-40.0M | $-344.1M | ||
| Q2 24 | $-37.9M | $-203.2M | ||
| Q1 24 | $-33.8M | $371.6M |
| Q4 25 | $255.9M | $308.9M | ||
| Q3 25 | $248.9M | $362.6M | ||
| Q2 25 | $232.1M | $379.2M | ||
| Q1 25 | $235.8M | $405.1M | ||
| Q4 24 | $233.1M | $437.4M | ||
| Q3 24 | $220.8M | $537.8M | ||
| Q2 24 | $218.1M | $691.5M | ||
| Q1 24 | $217.9M | $1.3B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-9.2M | $8.2M |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-9.2M | $8.2M | ||
| Q3 25 | $1.3M | $11.4M | ||
| Q2 25 | $-10.9M | $-21.3M | ||
| Q1 25 | $-8.9M | $8.5M | ||
| Q4 24 | $-11.8M | $-14.7M | ||
| Q3 24 | $3.4M | $-9.4M | ||
| Q2 24 | $-4.6M | $-11.9M | ||
| Q1 24 | $-9.5M | $-621.0K |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | $-11.1M | — | ||
| Q1 25 | $-9.0M | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $2.9M | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | -29.8% | — | ||
| Q1 25 | -23.1% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 9.0% | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | 0.0% | — | ||
| Q3 25 | 0.0% | — | ||
| Q2 25 | 0.6% | — | ||
| Q1 25 | 0.3% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 1.3% | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | -0.11× | ||
| Q1 25 | -3.37× | — | ||
| Q4 24 | -3.22× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
HRTX
| CINVANTI | $22.9M | 56% |
| ZYNRELEF | $12.5M | 31% |
| Aponvie | $3.8M | 9% |
| SUSTOL | $1.3M | 3% |
STEM
Segment breakdown not available.
