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Side-by-side financial comparison of HEALTHSTREAM INC (HSTM) and OPKO HEALTH, INC. (OPK). Click either name above to swap in a different company.

OPKO HEALTH, INC. is the larger business by last-quarter revenue ($148.5M vs $79.7M, roughly 1.9× HEALTHSTREAM INC). On growth, HEALTHSTREAM INC posted the faster year-over-year revenue change (7.4% vs -19.2%). HEALTHSTREAM INC produced more free cash flow last quarter ($13.0M vs $-28.6M). Over the past eight quarters, HEALTHSTREAM INC's revenue compounded faster (4.7% CAGR vs -7.5%).

HealthStream Inc is a leading U.S.-based provider of workforce development, compliance, and training solutions tailored for the healthcare industry. It offers cloud-based platforms covering clinical skill training, talent management, patient safety education, and regulatory adherence tools, serving over 4,000 healthcare organizations including hospitals, clinics, and long-term care facilities nationwide.

OPKO Health, Inc. is a medical test and medication company focused on diagnostics and pharmaceuticals. The company is a publicly traded company on NASDAQ and TASE under the symbol "OPK".

HSTM vs OPK — Head-to-Head

Bigger by revenue
OPK
OPK
1.9× larger
OPK
$148.5M
$79.7M
HSTM
Growing faster (revenue YoY)
HSTM
HSTM
+26.5% gap
HSTM
7.4%
-19.2%
OPK
More free cash flow
HSTM
HSTM
$41.6M more FCF
HSTM
$13.0M
$-28.6M
OPK
Faster 2-yr revenue CAGR
HSTM
HSTM
Annualised
HSTM
4.7%
-7.5%
OPK

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
HSTM
HSTM
OPK
OPK
Revenue
$79.7M
$148.5M
Net Profit
$-31.3M
Gross Margin
43.1%
Operating Margin
3.0%
-25.8%
Net Margin
-21.1%
Revenue YoY
7.4%
-19.2%
Net Profit YoY
-322.8%
EPS (diluted)
$0.09
$-0.04

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
HSTM
HSTM
OPK
OPK
Q4 25
$79.7M
$148.5M
Q3 25
$76.5M
$151.7M
Q2 25
$74.4M
$156.8M
Q1 25
$73.5M
$150.0M
Q4 24
$74.2M
$183.6M
Q3 24
$73.1M
$173.6M
Q2 24
$71.6M
$182.2M
Q1 24
$72.8M
$173.7M
Net Profit
HSTM
HSTM
OPK
OPK
Q4 25
$-31.3M
Q3 25
$6.1M
$21.6M
Q2 25
$5.4M
$-148.4M
Q1 25
$4.3M
$-67.6M
Q4 24
$14.0M
Q3 24
$5.7M
$24.9M
Q2 24
$4.2M
$-10.3M
Q1 24
$5.2M
$-81.8M
Gross Margin
HSTM
HSTM
OPK
OPK
Q4 25
43.1%
Q3 25
32.9%
Q2 25
31.5%
Q1 25
28.4%
Q4 24
46.1%
Q3 24
23.1%
Q2 24
28.4%
Q1 24
24.2%
Operating Margin
HSTM
HSTM
OPK
OPK
Q4 25
3.0%
-25.8%
Q3 25
9.9%
31.7%
Q2 25
7.9%
-38.3%
Q1 25
6.0%
-44.8%
Q4 24
6.3%
-18.0%
Q3 24
8.9%
8.2%
Q2 24
6.2%
-33.9%
Q1 24
7.8%
-41.2%
Net Margin
HSTM
HSTM
OPK
OPK
Q4 25
-21.1%
Q3 25
8.0%
14.3%
Q2 25
7.2%
-94.7%
Q1 25
5.9%
-45.1%
Q4 24
7.6%
Q3 24
7.8%
14.3%
Q2 24
5.8%
-5.7%
Q1 24
7.2%
-47.1%
EPS (diluted)
HSTM
HSTM
OPK
OPK
Q4 25
$0.09
$-0.04
Q3 25
$0.20
$0.03
Q2 25
$0.18
$-0.19
Q1 25
$0.14
$-0.10
Q4 24
$0.16
$0.02
Q3 24
$0.19
$0.03
Q2 24
$0.14
$-0.01
Q1 24
$0.17
$-0.12

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
HSTM
HSTM
OPK
OPK
Cash + ST InvestmentsLiquidity on hand
$36.2M
$364.4M
Total DebtLower is stronger
$344.0M
Stockholders' EquityBook value
$354.0M
$1.3B
Total Assets
$520.4M
$1.9B
Debt / EquityLower = less leverage
0.27×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
HSTM
HSTM
OPK
OPK
Q4 25
$36.2M
$364.4M
Q3 25
$53.5M
$412.0M
Q2 25
$52.1M
$267.3M
Q1 25
$77.3M
$428.8M
Q4 24
$59.5M
$426.6M
Q3 24
$57.5M
$400.1M
Q2 24
$46.1M
$40.6M
Q1 24
$52.4M
$75.6M
Total Debt
HSTM
HSTM
OPK
OPK
Q4 25
$344.0M
Q3 25
$344.2M
Q2 25
$343.3M
Q1 25
$439.2M
Q4 24
$437.2M
Q3 24
$441.0M
Q2 24
$201.9M
Q1 24
$350.1M
Stockholders' Equity
HSTM
HSTM
OPK
OPK
Q4 25
$354.0M
$1.3B
Q3 25
$349.2M
$1.3B
Q2 25
$350.6M
$1.3B
Q1 25
$362.8M
$1.3B
Q4 24
$359.4M
$1.4B
Q3 24
$355.5M
$1.4B
Q2 24
$349.2M
$1.4B
Q1 24
$344.9M
$1.3B
Total Assets
HSTM
HSTM
OPK
OPK
Q4 25
$520.4M
$1.9B
Q3 25
$499.9M
$2.0B
Q2 25
$500.1M
$2.0B
Q1 25
$524.0M
$2.1B
Q4 24
$510.8M
$2.2B
Q3 24
$502.8M
$2.3B
Q2 24
$499.6M
$2.0B
Q1 24
$511.6M
$2.0B
Debt / Equity
HSTM
HSTM
OPK
OPK
Q4 25
0.27×
Q3 25
0.26×
Q2 25
0.26×
Q1 25
0.33×
Q4 24
0.32×
Q3 24
0.31×
Q2 24
0.14×
Q1 24
0.28×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
HSTM
HSTM
OPK
OPK
Operating Cash FlowLast quarter
$13.2M
$-25.9M
Free Cash FlowOCF − Capex
$13.0M
$-28.6M
FCF MarginFCF / Revenue
16.3%
-19.3%
Capex IntensityCapex / Revenue
0.3%
1.8%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$59.6M
$-190.8M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
HSTM
HSTM
OPK
OPK
Q4 25
$13.2M
$-25.9M
Q3 25
$18.0M
$-34.6M
Q2 25
$5.0M
$-83.4M
Q1 25
$27.1M
$-34.6M
Q4 24
$11.2M
$-44.4M
Q3 24
$19.1M
$-77.1M
Q2 24
$6.5M
$-26.4M
Q1 24
$20.9M
$-35.6M
Free Cash Flow
HSTM
HSTM
OPK
OPK
Q4 25
$13.0M
$-28.6M
Q3 25
$17.9M
$-37.8M
Q2 25
$2.7M
$-86.7M
Q1 25
$26.0M
$-37.7M
Q4 24
$11.0M
$-49.8M
Q3 24
$18.8M
$-85.0M
Q2 24
$6.3M
$-33.7M
Q1 24
$20.2M
$-40.0M
FCF Margin
HSTM
HSTM
OPK
OPK
Q4 25
16.3%
-19.3%
Q3 25
23.4%
-24.9%
Q2 25
3.6%
-55.3%
Q1 25
35.4%
-25.2%
Q4 24
14.8%
-27.1%
Q3 24
25.8%
-49.0%
Q2 24
8.8%
-18.5%
Q1 24
27.8%
-23.0%
Capex Intensity
HSTM
HSTM
OPK
OPK
Q4 25
0.3%
1.8%
Q3 25
0.1%
2.1%
Q2 25
3.1%
2.1%
Q1 25
1.4%
2.1%
Q4 24
0.3%
2.9%
Q3 24
0.4%
4.6%
Q2 24
0.2%
4.0%
Q1 24
1.0%
2.6%
Cash Conversion
HSTM
HSTM
OPK
OPK
Q4 25
Q3 25
2.96×
-1.60×
Q2 25
0.93×
Q1 25
6.25×
Q4 24
-3.17×
Q3 24
3.34×
-3.10×
Q2 24
1.55×
Q1 24
4.01×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

HSTM
HSTM

Subscription Services$77.0M97%
Professional Services$2.7M3%

OPK
OPK

Services$71.1M48%
Transfer Of Intellectual Property And Other$33.7M23%
IE$22.1M15%
Rayaldee$8.8M6%
Barda Agreement$6.8M5%
MX$6.3M4%

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