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Side-by-side financial comparison of INSMED Inc (INSM) and PROSPERITY BANCSHARES INC (PB). Click either name above to swap in a different company.

PROSPERITY BANCSHARES INC is the larger business by last-quarter revenue ($367.6M vs $263.8M, roughly 1.4× INSMED Inc). PROSPERITY BANCSHARES INC runs the higher net margin — 31.6% vs -124.5%, a 156.1% gap on every dollar of revenue. Over the past eight quarters, INSMED Inc's revenue compounded faster (86.9% CAGR vs 19.2%).

Insmed Inc. is a global biopharmaceutical firm focused on developing and commercializing innovative therapies for patients with serious rare diseases that have high unmet medical needs. Its key offerings target pulmonary and endocrine rare disorders, serving markets across North America, Europe, and Asia Pacific.

Prosperity Bancshares, Inc. is a bank holding company headquartered in Houston, Texas with operations in Texas and central Oklahoma. As of December 31, 2019, the company operated 285 branches: 65 in the Houston area, including The Woodlands, Texas; 30 in South Texas, including Corpus Christi, Texas and Victoria, Texas; 75 in the Dallas–Fort Worth metroplex; 22 in East Texas; 29 in Central Texas, including Austin, Texas and San Antonio; 34 in West Texas, including Lubbock, Texas, Midland–Odess...

INSM vs PB — Head-to-Head

Bigger by revenue
PB
PB
1.4× larger
PB
$367.6M
$263.8M
INSM
Higher net margin
PB
PB
156.1% more per $
PB
31.6%
-124.5%
INSM
Faster 2-yr revenue CAGR
INSM
INSM
Annualised
INSM
86.9%
19.2%
PB

Income Statement — Q4 FY2025 vs Q1 FY2026

Metric
INSM
INSM
PB
PB
Revenue
$263.8M
$367.6M
Net Profit
$-328.5M
$116.3M
Gross Margin
83.2%
Operating Margin
-121.2%
Net Margin
-124.5%
31.6%
Revenue YoY
152.6%
Net Profit YoY
-39.5%
-10.7%
EPS (diluted)
$-1.55
$1.16

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
INSM
INSM
PB
PB
Q1 26
$367.6M
Q4 25
$263.8M
$275.0M
Q3 25
$142.3M
$273.4M
Q2 25
$107.4M
$267.7M
Q1 25
$92.8M
$265.4M
Q4 24
$104.4M
$267.8M
Q3 24
$93.4M
$261.7M
Q2 24
$90.3M
$258.8M
Net Profit
INSM
INSM
PB
PB
Q1 26
$116.3M
Q4 25
$-328.5M
$139.9M
Q3 25
$-370.0M
$137.6M
Q2 25
$-321.7M
$135.2M
Q1 25
$-256.6M
$130.2M
Q4 24
$-235.5M
$130.1M
Q3 24
$-220.5M
$127.3M
Q2 24
$-300.6M
$111.6M
Gross Margin
INSM
INSM
PB
PB
Q1 26
Q4 25
83.2%
Q3 25
79.4%
Q2 25
73.9%
Q1 25
77.1%
Q4 24
75.0%
Q3 24
77.3%
Q2 24
76.8%
Operating Margin
INSM
INSM
PB
PB
Q1 26
Q4 25
-121.2%
65.1%
Q3 25
-257.1%
64.4%
Q2 25
-291.3%
64.3%
Q1 25
-267.3%
62.7%
Q4 24
-220.6%
62.0%
Q3 24
-228.4%
62.1%
Q2 24
-319.8%
55.2%
Net Margin
INSM
INSM
PB
PB
Q1 26
31.6%
Q4 25
-124.5%
50.9%
Q3 25
-260.0%
50.3%
Q2 25
-299.5%
50.5%
Q1 25
-276.4%
49.1%
Q4 24
-225.5%
48.6%
Q3 24
-236.0%
48.6%
Q2 24
-332.8%
43.1%
EPS (diluted)
INSM
INSM
PB
PB
Q1 26
$1.16
Q4 25
$-1.55
$1.48
Q3 25
$-1.75
$1.45
Q2 25
$-1.70
$1.42
Q1 25
$-1.42
$1.37
Q4 24
$-1.30
$1.36
Q3 24
$-1.27
$1.34
Q2 24
$-1.94
$1.17

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
INSM
INSM
PB
PB
Cash + ST InvestmentsLiquidity on hand
$1.4B
Total DebtLower is stronger
$546.8M
Stockholders' EquityBook value
$739.0M
$8.2B
Total Assets
$2.3B
$43.6B
Debt / EquityLower = less leverage
0.74×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
INSM
INSM
PB
PB
Q1 26
Q4 25
$1.4B
Q3 25
$1.7B
Q2 25
$1.9B
Q1 25
$1.2B
Q4 24
$1.4B
Q3 24
$1.5B
Q2 24
$1.2B
Total Debt
INSM
INSM
PB
PB
Q1 26
Q4 25
$546.8M
Q3 25
$546.8M
Q2 25
$546.8M
Q1 25
$1.1B
Q4 24
$1.1B
Q3 24
$971.8M
Q2 24
$1.2B
Stockholders' Equity
INSM
INSM
PB
PB
Q1 26
$8.2B
Q4 25
$739.0M
$7.6B
Q3 25
$945.6M
$7.7B
Q2 25
$1.2B
$7.6B
Q1 25
$99.2M
$7.5B
Q4 24
$285.4M
$7.4B
Q3 24
$483.4M
$7.4B
Q2 24
$38.8M
$7.3B
Total Assets
INSM
INSM
PB
PB
Q1 26
$43.6B
Q4 25
$2.3B
$38.5B
Q3 25
$2.4B
$38.3B
Q2 25
$2.5B
$38.4B
Q1 25
$1.8B
$38.8B
Q4 24
$2.0B
$39.6B
Q3 24
$2.1B
$40.1B
Q2 24
$1.8B
$39.8B
Debt / Equity
INSM
INSM
PB
PB
Q1 26
Q4 25
0.74×
Q3 25
0.58×
Q2 25
0.44×
Q1 25
11.31×
Q4 24
3.93×
Q3 24
2.01×
Q2 24
30.66×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
INSM
INSM
PB
PB
Operating Cash FlowLast quarter
$-247.6M
Free Cash FlowOCF − Capex
$-264.2M
FCF MarginFCF / Revenue
-100.1%
Capex IntensityCapex / Revenue
6.3%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$-967.6M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
INSM
INSM
PB
PB
Q1 26
Q4 25
$-247.6M
$78.3M
Q3 25
$-219.8M
$194.8M
Q2 25
$-205.6M
$98.2M
Q1 25
$-262.1M
$178.2M
Q4 24
$-196.0M
$-205.8M
Q3 24
$-180.9M
$274.6M
Q2 24
$-123.0M
$216.5M
Free Cash Flow
INSM
INSM
PB
PB
Q1 26
Q4 25
$-264.2M
$68.5M
Q3 25
$-222.2M
$185.7M
Q2 25
$-209.1M
$91.8M
Q1 25
$-272.2M
$171.1M
Q4 24
$-202.8M
$-210.7M
Q3 24
$-184.6M
$270.2M
Q2 24
$-129.7M
$211.8M
FCF Margin
INSM
INSM
PB
PB
Q1 26
Q4 25
-100.1%
24.9%
Q3 25
-156.1%
67.9%
Q2 25
-194.6%
34.3%
Q1 25
-293.2%
64.5%
Q4 24
-194.1%
-78.7%
Q3 24
-197.6%
103.3%
Q2 24
-143.6%
81.8%
Capex Intensity
INSM
INSM
PB
PB
Q1 26
Q4 25
6.3%
3.6%
Q3 25
1.7%
3.3%
Q2 25
3.2%
2.4%
Q1 25
10.8%
2.7%
Q4 24
6.5%
1.8%
Q3 24
3.9%
1.7%
Q2 24
7.5%
1.8%
Cash Conversion
INSM
INSM
PB
PB
Q1 26
Q4 25
0.56×
Q3 25
1.42×
Q2 25
0.73×
Q1 25
1.37×
Q4 24
-1.58×
Q3 24
2.16×
Q2 24
1.94×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

INSM
INSM

Segment breakdown not available.

PB
PB

Net Interest Income$321.1M87%
Noninterest Income$46.5M13%

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