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Side-by-side financial comparison of Karyopharm Therapeutics Inc. (KPTI) and Simulations Plus, Inc. (SLP). Click either name above to swap in a different company.
Karyopharm Therapeutics Inc. is the larger business by last-quarter revenue ($34.1M vs $18.4M, roughly 1.9× Simulations Plus, Inc.). Simulations Plus, Inc. runs the higher net margin — 3.7% vs -299.9%, a 303.6% gap on every dollar of revenue. On growth, Karyopharm Therapeutics Inc. posted the faster year-over-year revenue change (11.6% vs -2.7%). Over the past eight quarters, Karyopharm Therapeutics Inc.'s revenue compounded faster (1.4% CAGR vs 0.3%).
Simulations Plus, Inc. develops absorption, distribution, metabolism, excretion, and toxicity (ADMET) modeling and simulation software for the pharmaceutical and biotechnology, industrial chemicals, cosmetics, food ingredients, and herbicide industries. In September 2014, the company acquired Cognigen Corporation, a provider of clinical trial data analysis and consulting services.
KPTI vs SLP — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $34.1M | $18.4M |
| Net Profit | $-102.2M | $676.0K |
| Gross Margin | — | 59.1% |
| Operating Margin | -52.4% | 3.9% |
| Net Margin | -299.9% | 3.7% |
| Revenue YoY | 11.6% | -2.7% |
| Net Profit YoY | -232.0% | 228.2% |
| EPS (diluted) | $-7.02 | $0.03 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $34.1M | $18.4M | ||
| Q3 25 | $44.0M | $17.5M | ||
| Q2 25 | $37.9M | $20.4M | ||
| Q1 25 | $30.0M | $22.4M | ||
| Q4 24 | $30.5M | $18.9M | ||
| Q3 24 | $38.8M | $18.7M | ||
| Q2 24 | $42.8M | $18.5M | ||
| Q1 24 | $33.1M | $18.3M |
| Q4 25 | $-102.2M | $676.0K | ||
| Q3 25 | $-33.1M | $-681.0K | ||
| Q2 25 | $-37.3M | $-67.3M | ||
| Q1 25 | $-23.5M | $3.1M | ||
| Q4 24 | $-30.8M | $206.0K | ||
| Q3 24 | $-32.1M | $843.0K | ||
| Q2 24 | $23.8M | $3.1M | ||
| Q1 24 | $-37.4M | $4.0M |
| Q4 25 | — | 59.1% | ||
| Q3 25 | — | 56.4% | ||
| Q2 25 | — | 64.0% | ||
| Q1 25 | — | 58.5% | ||
| Q4 24 | — | 54.0% | ||
| Q3 24 | — | 36.6% | ||
| Q2 24 | — | 71.5% | ||
| Q1 24 | — | 72.2% |
| Q4 25 | -52.4% | 3.9% | ||
| Q3 25 | -34.6% | 3.8% | ||
| Q2 25 | -64.3% | -364.5% | ||
| Q1 25 | -110.8% | 12.1% | ||
| Q4 24 | -102.4% | 0.7% | ||
| Q3 24 | -67.8% | -6.2% | ||
| Q2 24 | -65.7% | 10.1% | ||
| Q1 24 | -101.9% | 24.3% |
| Q4 25 | -299.9% | 3.7% | ||
| Q3 25 | -75.2% | -3.9% | ||
| Q2 25 | -98.2% | -330.6% | ||
| Q1 25 | -78.2% | 13.7% | ||
| Q4 24 | -100.8% | 1.1% | ||
| Q3 24 | -82.7% | 4.5% | ||
| Q2 24 | 55.6% | 16.9% | ||
| Q1 24 | -112.8% | 22.0% |
| Q4 25 | $-7.02 | $0.03 | ||
| Q3 25 | $-3.82 | $-0.03 | ||
| Q2 25 | $-4.32 | $-3.35 | ||
| Q1 25 | $-2.77 | $0.15 | ||
| Q4 24 | $-2.33 | $0.01 | ||
| Q3 24 | $-3.85 | $0.04 | ||
| Q2 24 | $-2.97 | $0.15 | ||
| Q1 24 | $-4.85 | $0.20 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $60.5M | $35.7M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $-292.9M | $127.1M |
| Total Assets | $108.4M | $137.8M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $60.5M | $35.7M | ||
| Q3 25 | $37.7M | $32.4M | ||
| Q2 25 | $38.7M | $28.4M | ||
| Q1 25 | $38.8M | $21.4M | ||
| Q4 24 | $62.5M | $18.2M | ||
| Q3 24 | $72.8M | $20.3M | ||
| Q2 24 | $84.8M | $119.0M | ||
| Q1 24 | $30.6M | $108.5M |
| Q4 25 | $-292.9M | $127.1M | ||
| Q3 25 | $-269.3M | $124.8M | ||
| Q2 25 | $-238.9M | $123.8M | ||
| Q1 25 | $-205.9M | $189.5M | ||
| Q4 24 | $-186.0M | $184.7M | ||
| Q3 24 | $-159.6M | $182.4M | ||
| Q2 24 | $-132.1M | $180.9M | ||
| Q1 24 | $-169.0M | $177.0M |
| Q4 25 | $108.4M | $137.8M | ||
| Q3 25 | $96.2M | $131.9M | ||
| Q2 25 | $104.9M | $134.4M | ||
| Q1 25 | $127.7M | $201.4M | ||
| Q4 24 | $164.4M | $196.9M | ||
| Q3 24 | $189.5M | $196.6M | ||
| Q2 24 | $214.0M | $192.7M | ||
| Q1 24 | $204.5M | $194.0M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-11.8M | $4.2M |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | 0.0% |
| Cash ConversionOCF / Net Profit | — | 6.26× |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-11.8M | $4.2M | ||
| Q3 25 | $-5.9M | $5.6M | ||
| Q2 25 | $-18.7M | $8.1M | ||
| Q1 25 | $-39.0M | $5.7M | ||
| Q4 24 | $-25.8M | $-1.3M | ||
| Q3 24 | $-19.5M | $1.7M | ||
| Q2 24 | $-38.5M | $5.7M | ||
| Q1 24 | $-43.7M | $5.8M |
| Q4 25 | — | — | ||
| Q3 25 | — | $5.3M | ||
| Q2 25 | — | $7.8M | ||
| Q1 25 | — | $5.6M | ||
| Q4 24 | $-25.9M | $-1.4M | ||
| Q3 24 | — | $1.6M | ||
| Q2 24 | — | $5.6M | ||
| Q1 24 | $-43.9M | $5.4M |
| Q4 25 | — | — | ||
| Q3 25 | — | 30.5% | ||
| Q2 25 | — | 38.5% | ||
| Q1 25 | — | 25.0% | ||
| Q4 24 | -84.7% | -7.2% | ||
| Q3 24 | — | 8.8% | ||
| Q2 24 | — | 30.0% | ||
| Q1 24 | -132.6% | 29.4% |
| Q4 25 | 0.0% | 0.0% | ||
| Q3 25 | 0.0% | 1.5% | ||
| Q2 25 | 0.0% | 1.5% | ||
| Q1 25 | 0.0% | 0.3% | ||
| Q4 24 | 0.2% | 0.5% | ||
| Q3 24 | 0.0% | 0.1% | ||
| Q2 24 | 0.0% | 0.6% | ||
| Q1 24 | 0.6% | 2.4% |
| Q4 25 | — | 6.26× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 1.84× | ||
| Q4 24 | — | -6.18× | ||
| Q3 24 | — | 1.97× | ||
| Q2 24 | -1.62× | 1.81× | ||
| Q1 24 | — | 1.44× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
KPTI
| Products | $32.1M | 94% |
| License And Other | $2.0M | 6% |
SLP
| Services Segment | $9.5M | 52% |
| Development | $7.2M | 39% |
| Discovery | $1.3M | 7% |
