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Side-by-side financial comparison of Neptune Insurance Holdings Inc. (NP) and Septerna, Inc. (SEPN). Click either name above to swap in a different company.

Neptune Insurance Holdings Inc. is the larger business by last-quarter revenue ($37.8M vs $24.1M, roughly 1.6× Septerna, Inc.). Neptune Insurance Holdings Inc. runs the higher net margin — 0.1% vs -44.5%, a 44.7% gap on every dollar of revenue.

Neptune Insurance Holdings Inc. is a specialty insurance holding company that offers a broad portfolio of property and casualty insurance products, with a core focus on residential and commercial flood insurance for customers across the United States. It serves both individual consumers and small to mid-sized business clients, using advanced data analytics to support accurate policy pricing and robust risk management.

Septerna, Inc. is a clinical-stage biotechnology company focused on developing novel therapies targeting G protein-coupled receptors (GPCRs), a large family of cell surface proteins involved in many disease pathways. Its pipeline includes candidates for inflammatory, metabolic, and central nervous system disorders, addressing global unmet medical needs.

NP vs SEPN — Head-to-Head

Bigger by revenue
NP
NP
1.6× larger
NP
$37.8M
$24.1M
SEPN
Higher net margin
NP
NP
44.7% more per $
NP
0.1%
-44.5%
SEPN

Income Statement — Q1 FY2026 vs Q4 FY2025

Metric
NP
NP
SEPN
SEPN
Revenue
$37.8M
$24.1M
Net Profit
$50.0K
$-10.7M
Gross Margin
Operating Margin
-66.4%
Net Margin
0.1%
-44.5%
Revenue YoY
28.8%
Net Profit YoY
0.0%
EPS (diluted)
$0.05
$-0.23

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
NP
NP
SEPN
SEPN
Q1 26
$37.8M
Q4 25
$24.1M
Q3 25
$44.4M
$21.5M
Q3 24
$33.8M
Net Profit
NP
NP
SEPN
SEPN
Q1 26
$50.0K
Q4 25
$-10.7M
Q3 25
$11.5M
$8.2M
Q3 24
$12.1M
Operating Margin
NP
NP
SEPN
SEPN
Q1 26
Q4 25
-66.4%
Q3 25
46.7%
12.2%
Q3 24
58.6%
Net Margin
NP
NP
SEPN
SEPN
Q1 26
0.1%
Q4 25
-44.5%
Q3 25
25.9%
38.0%
Q3 24
35.8%
EPS (diluted)
NP
NP
SEPN
SEPN
Q1 26
$0.05
Q4 25
$-0.23
Q3 25
$0.06
$0.18
Q3 24
$0.06

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
NP
NP
SEPN
SEPN
Cash + ST InvestmentsLiquidity on hand
$391.1M
Total DebtLower is stronger
Stockholders' EquityBook value
$381.9M
Total Assets
$596.2M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
NP
NP
SEPN
SEPN
Q1 26
Q4 25
$391.1M
Q3 25
$12.2M
$474.3M
Q3 24
Total Debt
NP
NP
SEPN
SEPN
Q1 26
Q4 25
Q3 25
$247.6M
Q3 24
Stockholders' Equity
NP
NP
SEPN
SEPN
Q1 26
Q4 25
$381.9M
Q3 25
$-509.5M
$388.7M
Q3 24
$-374.3M
Total Assets
NP
NP
SEPN
SEPN
Q1 26
Q4 25
$596.2M
Q3 25
$89.6M
$606.7M
Q3 24

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
NP
NP
SEPN
SEPN
Operating Cash FlowLast quarter
$-15.0M
Free Cash FlowOCF − Capex
$-15.1M
FCF MarginFCF / Revenue
-62.4%
Capex IntensityCapex / Revenue
0.3%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
NP
NP
SEPN
SEPN
Q1 26
Q4 25
$-15.0M
Q3 25
$38.9M
$168.8M
Q3 24
Free Cash Flow
NP
NP
SEPN
SEPN
Q1 26
Q4 25
$-15.1M
Q3 25
$168.8M
Q3 24
FCF Margin
NP
NP
SEPN
SEPN
Q1 26
Q4 25
-62.4%
Q3 25
785.3%
Q3 24
Capex Intensity
NP
NP
SEPN
SEPN
Q1 26
Q4 25
0.3%
Q3 25
0.1%
Q3 24
Cash Conversion
NP
NP
SEPN
SEPN
Q1 26
Q4 25
Q3 25
3.38×
20.65×
Q3 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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