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Side-by-side financial comparison of OPKO HEALTH, INC. (OPK) and OCTAVE SPECIALTY GROUP INC (OSG). Click either name above to swap in a different company.

OPKO HEALTH, INC. is the larger business by last-quarter revenue ($148.5M vs $104.2M, roughly 1.4× OCTAVE SPECIALTY GROUP INC). OCTAVE SPECIALTY GROUP INC runs the higher net margin — -6.6% vs -21.1%, a 14.5% gap on every dollar of revenue. On growth, OCTAVE SPECIALTY GROUP INC posted the faster year-over-year revenue change (66.0% vs -19.2%). Over the past eight quarters, OCTAVE SPECIALTY GROUP INC's revenue compounded faster (42.9% CAGR vs -7.5%).

OPKO Health, Inc. is a medical test and medication company focused on diagnostics and pharmaceuticals. The company is a publicly traded company on NASDAQ and TASE under the symbol "OPK".

Octave Specialty Group Inc. is a specialty insurance holding company that provides tailored property and casualty insurance products. Its core business focuses on excess and surplus lines, catering to commercial and individual clients across primary North American markets with customized risk coverage solutions.

OPK vs OSG — Head-to-Head

Bigger by revenue
OPK
OPK
1.4× larger
OPK
$148.5M
$104.2M
OSG
Growing faster (revenue YoY)
OSG
OSG
+85.2% gap
OSG
66.0%
-19.2%
OPK
Higher net margin
OSG
OSG
14.5% more per $
OSG
-6.6%
-21.1%
OPK
Faster 2-yr revenue CAGR
OSG
OSG
Annualised
OSG
42.9%
-7.5%
OPK

Income Statement — Q4 FY2025 vs Q1 FY2026

Metric
OPK
OPK
OSG
OSG
Revenue
$148.5M
$104.2M
Net Profit
$-31.3M
$-6.9M
Gross Margin
43.1%
Operating Margin
-25.8%
Net Margin
-21.1%
-6.6%
Revenue YoY
-19.2%
66.0%
Net Profit YoY
-322.8%
EPS (diluted)
$-0.04
$-0.13

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
OPK
OPK
OSG
OSG
Q1 26
$104.2M
Q4 25
$148.5M
$66.9M
Q3 25
$151.7M
$66.6M
Q2 25
$156.8M
$55.0M
Q1 25
$150.0M
$62.8M
Q4 24
$183.6M
$65.2M
Q3 24
$173.6M
$70.0M
Q2 24
$182.2M
$51.0M
Net Profit
OPK
OPK
OSG
OSG
Q1 26
$-6.9M
Q4 25
$-31.3M
$-29.7M
Q3 25
$21.6M
$-112.6M
Q2 25
$-148.4M
$-72.7M
Q1 25
$-67.6M
$-44.7M
Q4 24
$14.0M
$-20.9M
Q3 24
$24.9M
$-27.5M
Q2 24
$-10.3M
$-750.0K
Gross Margin
OPK
OPK
OSG
OSG
Q1 26
Q4 25
43.1%
Q3 25
32.9%
Q2 25
31.5%
Q1 25
28.4%
Q4 24
46.1%
Q3 24
23.1%
Q2 24
28.4%
Operating Margin
OPK
OPK
OSG
OSG
Q1 26
Q4 25
-25.8%
-76.7%
Q3 25
31.7%
-48.2%
Q2 25
-38.3%
-41.8%
Q1 25
-44.8%
-24.1%
Q4 24
-18.0%
-55.5%
Q3 24
8.2%
-29.7%
Q2 24
-33.9%
-28.9%
Net Margin
OPK
OPK
OSG
OSG
Q1 26
-6.6%
Q4 25
-21.1%
-73.8%
Q3 25
14.3%
-169.1%
Q2 25
-94.7%
-132.3%
Q1 25
-45.1%
-71.3%
Q4 24
7.6%
-55.1%
Q3 24
14.3%
-39.3%
Q2 24
-5.7%
-1.5%
EPS (diluted)
OPK
OPK
OSG
OSG
Q1 26
$-0.13
Q4 25
$-0.04
$-0.82
Q3 25
$0.03
$-2.35
Q2 25
$-0.19
$-1.54
Q1 25
$-0.10
$-1.22
Q4 24
$0.02
$-11.75
Q3 24
$0.03
$-0.63
Q2 24
$-0.01
$-0.02

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
OPK
OPK
OSG
OSG
Cash + ST InvestmentsLiquidity on hand
$364.4M
Total DebtLower is stronger
$344.0M
$117.1M
Stockholders' EquityBook value
$1.3B
$833.6M
Total Assets
$1.9B
$2.3B
Debt / EquityLower = less leverage
0.27×
0.14×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
OPK
OPK
OSG
OSG
Q1 26
Q4 25
$364.4M
$146.4M
Q3 25
$412.0M
$27.5M
Q2 25
$267.3M
$22.5M
Q1 25
$428.8M
$34.1M
Q4 24
$426.6M
$157.2M
Q3 24
$400.1M
$40.8M
Q2 24
$40.6M
$14.6M
Total Debt
OPK
OPK
OSG
OSG
Q1 26
$117.1M
Q4 25
$344.0M
$117.6M
Q3 25
$344.2M
Q2 25
$343.3M
Q1 25
$439.2M
Q4 24
$437.2M
$0
Q3 24
$441.0M
$518.0M
Q2 24
$201.9M
$515.0M
Stockholders' Equity
OPK
OPK
OSG
OSG
Q1 26
$833.6M
Q4 25
$1.3B
$715.8M
Q3 25
$1.3B
$843.4M
Q2 25
$1.3B
$859.8M
Q1 25
$1.3B
$852.2M
Q4 24
$1.4B
$798.4M
Q3 24
$1.4B
$1.5B
Q2 24
$1.4B
$1.4B
Total Assets
OPK
OPK
OSG
OSG
Q1 26
$2.3B
Q4 25
$1.9B
$2.2B
Q3 25
$2.0B
$2.1B
Q2 25
$2.0B
$8.5B
Q1 25
$2.1B
$8.3B
Q4 24
$2.2B
$8.1B
Q3 24
$2.3B
$9.3B
Q2 24
$2.0B
$8.2B
Debt / Equity
OPK
OPK
OSG
OSG
Q1 26
0.14×
Q4 25
0.27×
0.16×
Q3 25
0.26×
Q2 25
0.26×
Q1 25
0.33×
Q4 24
0.32×
0.00×
Q3 24
0.31×
0.35×
Q2 24
0.14×
0.38×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
OPK
OPK
OSG
OSG
Operating Cash FlowLast quarter
$-25.9M
Free Cash FlowOCF − Capex
$-28.6M
FCF MarginFCF / Revenue
-19.3%
Capex IntensityCapex / Revenue
1.8%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$-190.8M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
OPK
OPK
OSG
OSG
Q1 26
Q4 25
$-25.9M
$-52.3M
Q3 25
$-34.6M
$-41.2M
Q2 25
$-83.4M
$2.1M
Q1 25
$-34.6M
$-12.6M
Q4 24
$-44.4M
$762.0K
Q3 24
$-77.1M
$48.9M
Q2 24
$-26.4M
$20.4M
Free Cash Flow
OPK
OPK
OSG
OSG
Q1 26
Q4 25
$-28.6M
Q3 25
$-37.8M
Q2 25
$-86.7M
Q1 25
$-37.7M
Q4 24
$-49.8M
Q3 24
$-85.0M
Q2 24
$-33.7M
FCF Margin
OPK
OPK
OSG
OSG
Q1 26
Q4 25
-19.3%
Q3 25
-24.9%
Q2 25
-55.3%
Q1 25
-25.2%
Q4 24
-27.1%
Q3 24
-49.0%
Q2 24
-18.5%
Capex Intensity
OPK
OPK
OSG
OSG
Q1 26
Q4 25
1.8%
Q3 25
2.1%
Q2 25
2.1%
Q1 25
2.1%
Q4 24
2.9%
Q3 24
4.6%
Q2 24
4.0%
Cash Conversion
OPK
OPK
OSG
OSG
Q1 26
Q4 25
Q3 25
-1.60×
Q2 25
Q1 25
Q4 24
-3.17×
Q3 24
-3.10×
Q2 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

OPK
OPK

Services$71.1M48%
Transfer Of Intellectual Property And Other$33.7M23%
IE$22.1M15%
Rayaldee$8.8M6%
Barda Agreement$6.8M5%
MX$6.3M4%

OSG
OSG

Commissions$68.2M65%
Other$20.6M20%
Servicing and other fees$9.4M9%
Program fees$3.6M3%
Investment income$2.4M2%

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