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Side-by-side financial comparison of Prime Medicine, Inc. (PRME) and Quantum-Si Inc (QSI). Click either name above to swap in a different company.
Prime Medicine, Inc. is the larger business by last-quarter revenue ($838.0K vs $451.0K, roughly 1.9× Quantum-Si Inc). Quantum-Si Inc runs the higher net margin — -3904.9% vs -5498.7%, a 1593.8% gap on every dollar of revenue. On growth, Prime Medicine, Inc. posted the faster year-over-year revenue change (-61.6% vs -62.2%). Quantum-Si Inc produced more free cash flow last quarter ($-16.4M vs $-37.5M).
Prime Medicine, Inc. is an American biotechnology company developing gene therapies based on prime editing. The company is headquartered in Cambridge, Massachusetts.
Silicon Quantum Computing Pty Ltd (SQC) is a Sydney, Australia-based quantum computing company.
PRME vs QSI — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $838.0K | $451.0K |
| Net Profit | $-46.1M | $-17.6M |
| Gross Margin | — | 27.1% |
| Operating Margin | -5800.5% | -4677.2% |
| Net Margin | -5498.7% | -3904.9% |
| Revenue YoY | -61.6% | -62.2% |
| Net Profit YoY | -9.0% | 46.8% |
| EPS (diluted) | $-0.22 | $-0.07 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $838.0K | $451.0K | ||
| Q3 25 | $1.2M | $552.0K | ||
| Q2 25 | $1.1M | $591.0K | ||
| Q1 25 | $1.5M | $842.0K | ||
| Q4 24 | $2.2M | $1.2M | ||
| Q3 24 | — | $787.0K | ||
| Q2 24 | $0 | $622.0K | ||
| Q1 24 | $591.0K | $457.0K |
| Q4 25 | $-46.1M | $-17.6M | ||
| Q3 25 | $-50.6M | $-35.7M | ||
| Q2 25 | $-52.6M | $-28.8M | ||
| Q1 25 | $-51.9M | $-19.2M | ||
| Q4 24 | $-42.3M | $-33.1M | ||
| Q3 24 | — | $-25.3M | ||
| Q2 24 | $-55.3M | $-23.1M | ||
| Q1 24 | $-45.8M | $-19.5M |
| Q4 25 | — | 27.1% | ||
| Q3 25 | — | 35.1% | ||
| Q2 25 | — | 59.4% | ||
| Q1 25 | — | 57.7% | ||
| Q4 24 | — | 51.2% | ||
| Q3 24 | — | 46.6% | ||
| Q2 24 | — | 56.9% | ||
| Q1 24 | — | 58.9% |
| Q4 25 | -5800.5% | -4677.2% | ||
| Q3 25 | -4406.0% | -7205.3% | ||
| Q2 25 | -4787.2% | -5096.4% | ||
| Q1 25 | -3603.3% | -2982.4% | ||
| Q4 24 | -2025.7% | -2573.6% | ||
| Q3 24 | — | -3569.0% | ||
| Q2 24 | — | -4252.6% | ||
| Q1 24 | -8179.5% | -5111.6% |
| Q4 25 | -5498.7% | -3904.9% | ||
| Q3 25 | -4129.1% | -6467.9% | ||
| Q2 25 | -4716.7% | -4879.2% | ||
| Q1 25 | -3568.8% | -2279.0% | ||
| Q4 24 | -1936.6% | -2778.6% | ||
| Q3 24 | — | -3216.4% | ||
| Q2 24 | — | -3713.7% | ||
| Q1 24 | -7743.0% | -4261.3% |
| Q4 25 | $-0.22 | $-0.07 | ||
| Q3 25 | $-0.32 | $-0.17 | ||
| Q2 25 | $-0.41 | $-0.16 | ||
| Q1 25 | $-0.40 | $-0.11 | ||
| Q4 24 | $-0.31 | $-0.23 | ||
| Q3 24 | — | $-0.18 | ||
| Q2 24 | $-0.46 | $-0.16 | ||
| Q1 24 | $-0.44 | $-0.14 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $63.0M | $21.6M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $120.9M | $220.2M |
| Total Assets | $342.7M | $245.6M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $63.0M | $21.6M | ||
| Q3 25 | $71.4M | $30.9M | ||
| Q2 25 | $53.8M | $22.2M | ||
| Q1 25 | $91.9M | $37.3M | ||
| Q4 24 | $182.5M | $49.2M | ||
| Q3 24 | — | $42.3M | ||
| Q2 24 | $55.6M | $59.6M | ||
| Q1 24 | $94.2M | $53.2M |
| Q4 25 | $120.9M | $220.2M | ||
| Q3 25 | $161.8M | $235.2M | ||
| Q2 25 | $60.9M | $221.0M | ||
| Q1 25 | $106.9M | $246.9M | ||
| Q4 24 | $153.1M | $215.4M | ||
| Q3 24 | — | $210.5M | ||
| Q2 24 | $196.6M | $233.3M | ||
| Q1 24 | $243.8M | $253.8M |
| Q4 25 | $342.7M | $245.6M | ||
| Q3 25 | $385.0M | $260.1M | ||
| Q2 25 | $279.0M | $254.4M | ||
| Q1 25 | $328.2M | $271.2M | ||
| Q4 24 | $297.5M | $247.9M | ||
| Q3 24 | — | $236.5M | ||
| Q2 24 | $259.7M | $256.7M | ||
| Q1 24 | $311.4M | $275.6M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-37.3M | $-16.3M |
| Free Cash FlowOCF − Capex | $-37.5M | $-16.4M |
| FCF MarginFCF / Revenue | -4480.4% | -3628.4% |
| Capex IntensityCapex / Revenue | 34.6% | 3.8% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-167.1M | $-97.3M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-37.3M | $-16.3M | ||
| Q3 25 | $-35.0M | $-32.0M | ||
| Q2 25 | $-41.4M | $-20.2M | ||
| Q1 25 | $-48.9M | $-26.2M | ||
| Q4 24 | $16.2M | $-22.9M | ||
| Q3 24 | — | $-23.2M | ||
| Q2 24 | $-45.5M | $-18.6M | ||
| Q1 24 | $-67.7M | $-23.2M |
| Q4 25 | $-37.5M | $-16.4M | ||
| Q3 25 | $-35.3M | $-32.9M | ||
| Q2 25 | $-43.0M | $-20.5M | ||
| Q1 25 | $-51.3M | $-27.5M | ||
| Q4 24 | $14.5M | $-24.3M | ||
| Q3 24 | — | $-24.1M | ||
| Q2 24 | $-47.4M | $-19.7M | ||
| Q1 24 | $-70.0M | $-24.3M |
| Q4 25 | -4480.4% | -3628.4% | ||
| Q3 25 | -2880.5% | -5963.6% | ||
| Q2 25 | -3855.1% | -3472.8% | ||
| Q1 25 | -3526.8% | -3261.4% | ||
| Q4 24 | 662.1% | -2039.9% | ||
| Q3 24 | — | -3065.8% | ||
| Q2 24 | — | -3164.0% | ||
| Q1 24 | -11849.6% | -5307.2% |
| Q4 25 | 34.6% | 3.8% | ||
| Q3 25 | 20.2% | 163.0% | ||
| Q2 25 | 141.0% | 55.3% | ||
| Q1 25 | 166.6% | 155.2% | ||
| Q4 24 | 82.0% | 120.4% | ||
| Q3 24 | — | 123.9% | ||
| Q2 24 | — | 181.2% | ||
| Q1 24 | 393.2% | 228.9% |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
