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Side-by-side financial comparison of Prime Medicine, Inc. (PRME) and Spyre Therapeutics, Inc. (SYRE). Click either name above to swap in a different company.
Prime Medicine, Inc. is an American biotechnology company developing gene therapies based on prime editing. The company is headquartered in Cambridge, Massachusetts.
Spyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering and developing targeted next-generation therapies for patients with rare, serious autoimmune and inflammatory diseases. It advances pipeline candidates through preclinical and early clinical stages to address unmet medical needs for global patient populations.
PRME vs SYRE — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2024
| Metric | | |
|---|---|---|
| Revenue | $838.0K | $0 |
| Net Profit | $-46.1M | — |
| Gross Margin | — | — |
| Operating Margin | -5800.5% | — |
| Net Margin | -5498.7% | — |
| Revenue YoY | -61.6% | — |
| Net Profit YoY | -9.0% | — |
| EPS (diluted) | $-0.22 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $838.0K | — | ||
| Q3 25 | $1.2M | — | ||
| Q2 25 | $1.1M | — | ||
| Q1 25 | $1.5M | — | ||
| Q4 24 | $2.2M | $0 | ||
| Q3 24 | — | $0 | ||
| Q2 24 | $0 | $0 | ||
| Q1 24 | $591.0K | $0 |
| Q4 25 | $-46.1M | — | ||
| Q3 25 | $-50.6M | — | ||
| Q2 25 | $-52.6M | — | ||
| Q1 25 | $-51.9M | — | ||
| Q4 24 | $-42.3M | — | ||
| Q3 24 | — | $-69.0M | ||
| Q2 24 | $-55.3M | $-38.8M | ||
| Q1 24 | $-45.8M | $-43.9M |
| Q4 25 | -5800.5% | — | ||
| Q3 25 | -4406.0% | — | ||
| Q2 25 | -4787.2% | — | ||
| Q1 25 | -3603.3% | — | ||
| Q4 24 | -2025.7% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -8179.5% | — |
| Q4 25 | -5498.7% | — | ||
| Q3 25 | -4129.1% | — | ||
| Q2 25 | -4716.7% | — | ||
| Q1 25 | -3568.8% | — | ||
| Q4 24 | -1936.6% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -7743.0% | — |
| Q4 25 | $-0.22 | — | ||
| Q3 25 | $-0.32 | — | ||
| Q2 25 | $-0.41 | — | ||
| Q1 25 | $-0.40 | — | ||
| Q4 24 | $-0.31 | — | ||
| Q3 24 | — | $1.06 | ||
| Q2 24 | $-0.46 | $0.59 | ||
| Q1 24 | $-0.44 | $0.72 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $63.0M | $89.4M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $120.9M | $517.8M |
| Total Assets | $342.7M | $608.5M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $63.0M | — | ||
| Q3 25 | $71.4M | — | ||
| Q2 25 | $53.8M | — | ||
| Q1 25 | $91.9M | — | ||
| Q4 24 | $182.5M | $89.4M | ||
| Q3 24 | — | $71.6M | ||
| Q2 24 | $55.6M | $45.1M | ||
| Q1 24 | $94.2M | $227.6M |
| Q4 25 | $120.9M | — | ||
| Q3 25 | $161.8M | — | ||
| Q2 25 | $60.9M | — | ||
| Q1 25 | $106.9M | — | ||
| Q4 24 | $153.1M | $517.8M | ||
| Q3 24 | — | $327.4M | ||
| Q2 24 | $196.6M | $374.4M | ||
| Q1 24 | $243.8M | $152.3M |
| Q4 25 | $342.7M | — | ||
| Q3 25 | $385.0M | — | ||
| Q2 25 | $279.0M | — | ||
| Q1 25 | $328.2M | — | ||
| Q4 24 | $297.5M | $608.5M | ||
| Q3 24 | — | $421.1M | ||
| Q2 24 | $259.7M | $436.1M | ||
| Q1 24 | $311.4M | $487.6M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-37.3M | $-37.2M |
| Free Cash FlowOCF − Capex | $-37.5M | — |
| FCF MarginFCF / Revenue | -4480.4% | — |
| Capex IntensityCapex / Revenue | 34.6% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-167.1M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-37.3M | — | ||
| Q3 25 | $-35.0M | — | ||
| Q2 25 | $-41.4M | — | ||
| Q1 25 | $-48.9M | — | ||
| Q4 24 | $16.2M | $-37.2M | ||
| Q3 24 | — | $-29.4M | ||
| Q2 24 | $-45.5M | $-62.2M | ||
| Q1 24 | $-67.7M | $-28.5M |
| Q4 25 | $-37.5M | — | ||
| Q3 25 | $-35.3M | — | ||
| Q2 25 | $-43.0M | — | ||
| Q1 25 | $-51.3M | — | ||
| Q4 24 | $14.5M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | $-47.4M | — | ||
| Q1 24 | $-70.0M | — |
| Q4 25 | -4480.4% | — | ||
| Q3 25 | -2880.5% | — | ||
| Q2 25 | -3855.1% | — | ||
| Q1 25 | -3526.8% | — | ||
| Q4 24 | 662.1% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -11849.6% | — |
| Q4 25 | 34.6% | — | ||
| Q3 25 | 20.2% | — | ||
| Q2 25 | 141.0% | — | ||
| Q1 25 | 166.6% | — | ||
| Q4 24 | 82.0% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | 393.2% | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
