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Side-by-side financial comparison of Protagonist Therapeutics, Inc (PTGX) and Riley Exploration Permian, Inc. (REPX). Click either name above to swap in a different company.
Protagonist Therapeutics, Inc is the larger business by last-quarter revenue ($170.6M vs $97.3M, roughly 1.8× Riley Exploration Permian, Inc.). On growth, Protagonist Therapeutics, Inc posted the faster year-over-year revenue change (184.4% vs -5.3%).
Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing novel peptide-based targeted therapies for unmet medical needs, primarily covering gastrointestinal disorders, inflammatory diseases and rare disease indications. Its lead product candidates target inflammatory bowel disease and other chronic immune-related conditions, with operations spanning global R&D and partnership collaborations.
Riley Exploration Permian, Inc. is an independent energy company focused on exploration, development, and production of crude oil, natural gas, and natural gas liquids primarily in the US Permian Basin spanning Texas and New Mexico. It prioritizes cost-efficient onshore reserve development to supply reliable energy products to North American markets.
PTGX vs REPX — Head-to-Head
Income Statement — Q4 FY2024 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $170.6M | $97.3M |
| Net Profit | $131.7M | — |
| Gross Margin | — | — |
| Operating Margin | 74.3% | 26.9% |
| Net Margin | 77.2% | — |
| Revenue YoY | 184.4% | -5.3% |
| Net Profit YoY | 381.7% | — |
| EPS (diluted) | $2.01 | $4.02 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $97.3M | ||
| Q3 25 | — | $106.9M | ||
| Q2 25 | — | $85.4M | ||
| Q1 25 | — | $102.5M | ||
| Q4 24 | $170.6M | $102.7M | ||
| Q3 24 | — | $102.3M | ||
| Q2 24 | — | $105.4M | ||
| Q1 24 | $255.0M | $99.7M |
| Q4 25 | — | — | ||
| Q3 25 | — | $16.3M | ||
| Q2 25 | — | $30.5M | ||
| Q1 25 | — | $28.6M | ||
| Q4 24 | $131.7M | — | ||
| Q3 24 | — | $25.7M | ||
| Q2 24 | — | $33.5M | ||
| Q1 24 | $207.3M | $18.8M |
| Q4 25 | — | 26.9% | ||
| Q3 25 | — | 27.0% | ||
| Q2 25 | — | 33.7% | ||
| Q1 25 | — | 48.3% | ||
| Q4 24 | 74.3% | 31.2% | ||
| Q3 24 | — | 17.1% | ||
| Q2 24 | — | 50.9% | ||
| Q1 24 | 80.9% | 50.7% |
| Q4 25 | — | — | ||
| Q3 25 | — | 15.3% | ||
| Q2 25 | — | 35.7% | ||
| Q1 25 | — | 27.9% | ||
| Q4 24 | 77.2% | — | ||
| Q3 24 | — | 25.1% | ||
| Q2 24 | — | 31.8% | ||
| Q1 24 | 81.3% | 18.8% |
| Q4 25 | — | $4.02 | ||
| Q3 25 | — | $0.77 | ||
| Q2 25 | — | $1.44 | ||
| Q1 25 | — | $1.36 | ||
| Q4 24 | $2.01 | $0.52 | ||
| Q3 24 | — | $1.21 | ||
| Q2 24 | — | $1.59 | ||
| Q1 24 | $3.26 | $0.94 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $418.9M | — |
| Total DebtLower is stronger | — | $247.9M |
| Stockholders' EquityBook value | $675.3M | $634.2M |
| Total Assets | $744.7M | $1.2B |
| Debt / EquityLower = less leverage | — | 0.39× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $418.9M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | $322.6M | — |
| Q4 25 | — | $247.9M | ||
| Q3 25 | — | $367.0M | ||
| Q2 25 | — | $275.2M | ||
| Q1 25 | — | $249.3M | ||
| Q4 24 | — | $269.5M | ||
| Q3 24 | — | $288.6M | ||
| Q2 24 | — | $322.7M | ||
| Q1 24 | — | $341.8M |
| Q4 25 | — | $634.2M | ||
| Q3 25 | — | $566.5M | ||
| Q2 25 | — | $556.9M | ||
| Q1 25 | — | $532.4M | ||
| Q4 24 | $675.3M | $510.6M | ||
| Q3 24 | — | $507.4M | ||
| Q2 24 | — | $489.0M | ||
| Q1 24 | $560.4M | $434.6M |
| Q4 25 | — | $1.2B | ||
| Q3 25 | — | $1.2B | ||
| Q2 25 | — | $1.0B | ||
| Q1 25 | — | $994.9M | ||
| Q4 24 | $744.7M | $993.5M | ||
| Q3 24 | — | $997.9M | ||
| Q2 24 | — | $1.0B | ||
| Q1 24 | $629.3M | $956.4M |
| Q4 25 | — | 0.39× | ||
| Q3 25 | — | 0.65× | ||
| Q2 25 | — | 0.49× | ||
| Q1 25 | — | 0.47× | ||
| Q4 24 | — | 0.53× | ||
| Q3 24 | — | 0.57× | ||
| Q2 24 | — | 0.66× | ||
| Q1 24 | — | 0.79× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $184.2M | $64.9M |
| Free Cash FlowOCF − Capex | $182.8M | — |
| FCF MarginFCF / Revenue | 107.1% | — |
| Capex IntensityCapex / Revenue | 0.8% | — |
| Cash ConversionOCF / Net Profit | 1.40× | — |
| TTM Free Cash FlowTrailing 4 quarters | $101.7M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $64.9M | ||
| Q3 25 | — | $63.6M | ||
| Q2 25 | — | $33.6M | ||
| Q1 25 | — | $50.4M | ||
| Q4 24 | $184.2M | $66.4M | ||
| Q3 24 | — | $72.1M | ||
| Q2 24 | — | $51.6M | ||
| Q1 24 | $-27.4M | $56.1M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $182.8M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | $-27.7M | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 107.1% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -10.9% | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 0.8% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | 0.1% | — |
| Q4 25 | — | — | ||
| Q3 25 | — | 3.90× | ||
| Q2 25 | — | 1.10× | ||
| Q1 25 | — | 1.76× | ||
| Q4 24 | 1.40× | — | ||
| Q3 24 | — | 2.81× | ||
| Q2 24 | — | 1.54× | ||
| Q1 24 | -0.13× | 2.99× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
