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Side-by-side financial comparison of AGENUS INC (AGEN) and American Express (AXP). Click either name above to swap in a different company.
AGENUS INC is the larger business by last-quarter revenue ($34.2M vs $18.9M, roughly 1.8× American Express). American Express runs the higher net margin — 15.7% vs -31.0%, a 46.7% gap on every dollar of revenue. On growth, AGENUS INC posted the faster year-over-year revenue change (27.5% vs 11.4%). Over the past eight quarters, AGENUS INC's revenue compounded faster (10.5% CAGR vs -95.6%).
Agenus Inc. is a Lexington, Massachusetts-based biotechnology company focused on immunotherapy including immuno-oncology, a field that uses the immune system to control or cure cancer. The company is developing checkpoint modulators (CPMs), patient-specific anti-cancer vaccines, and adjuvants designed for use with various vaccines. CPM development is a particularly fast-moving field, since early products have produced unprecedented clinical benefits for patients.
American Express Company, together with its subsidiaries, provides charge and credit payment card products, and travel-related services worldwide. The company operates through three segments: Global Consumer Services Group, Global Commercial Services, and Global Merchant and Network Services. Its products and services include payment and financing products; network services; accounts payable expense management products and services; and travel and lifestyle services. The company's products an...
AGEN vs AXP — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $34.2M | $18.9M |
| Net Profit | $-10.6M | $3.0M |
| Gross Margin | — | — |
| Operating Margin | 42.1% | — |
| Net Margin | -31.0% | 15.7% |
| Revenue YoY | 27.5% | 11.4% |
| Net Profit YoY | 77.3% | 15.0% |
| EPS (diluted) | $0.09 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $18.9M | ||
| Q4 25 | $34.2M | $10.9B | ||
| Q3 25 | $30.2M | $10.4B | ||
| Q2 25 | $25.7M | $10.3B | ||
| Q1 25 | $24.1M | $9.6B | ||
| Q4 24 | $26.8M | $10.0B | ||
| Q3 24 | $25.1M | $9.7B | ||
| Q2 24 | $23.5M | $9.8B |
| Q1 26 | — | $3.0M | ||
| Q4 25 | $-10.6M | $2.5B | ||
| Q3 25 | $63.9M | $2.9B | ||
| Q2 25 | $-30.0M | $2.9B | ||
| Q1 25 | $-26.4M | $2.6B | ||
| Q4 24 | $-46.8M | $2.2B | ||
| Q3 24 | $-67.2M | $2.5B | ||
| Q2 24 | $-54.8M | $3.0B |
| Q1 26 | — | — | ||
| Q4 25 | — | — | ||
| Q3 25 | 97.9% | — | ||
| Q2 25 | 99.1% | — | ||
| Q1 25 | 99.4% | — | ||
| Q4 24 | 99.6% | — | ||
| Q3 24 | 99.4% | — | ||
| Q2 24 | 99.5% | — |
| Q1 26 | — | — | ||
| Q4 25 | 42.1% | 28.2% | ||
| Q3 25 | -15.0% | 36.7% | ||
| Q2 25 | -65.0% | 34.4% | ||
| Q1 25 | -55.3% | 34.6% | ||
| Q4 24 | -96.5% | 27.7% | ||
| Q3 24 | -125.5% | 33.0% | ||
| Q2 24 | -128.4% | 38.6% |
| Q1 26 | — | 15.7% | ||
| Q4 25 | -31.0% | 22.5% | ||
| Q3 25 | 211.4% | 27.9% | ||
| Q2 25 | -116.8% | 28.0% | ||
| Q1 25 | -109.6% | 26.8% | ||
| Q4 24 | -174.4% | 21.8% | ||
| Q3 24 | -267.7% | 25.8% | ||
| Q2 24 | -233.1% | 30.7% |
| Q1 26 | — | — | ||
| Q4 25 | $0.09 | $3.52 | ||
| Q3 25 | $1.94 | $4.14 | ||
| Q2 25 | $-1.00 | $4.08 | ||
| Q1 25 | $-1.03 | $3.64 | ||
| Q4 24 | $-1.95 | $3.04 | ||
| Q3 24 | $-3.08 | $3.49 | ||
| Q2 24 | $-2.52 | $4.15 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $3.0M | — |
| Total DebtLower is stronger | $44.7M | $60.4M |
| Stockholders' EquityBook value | $-271.1M | $34.0M |
| Total Assets | $226.8M | $308.9M |
| Debt / EquityLower = less leverage | — | 1.78× |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $3.0M | $742.0M | ||
| Q3 25 | $3.5M | $1.3B | ||
| Q2 25 | $9.5M | $197.0M | ||
| Q1 25 | $18.5M | $261.0M | ||
| Q4 24 | $40.4M | $221.0M | ||
| Q3 24 | $44.8M | $120.0M | ||
| Q2 24 | $93.7M | $188.0M |
| Q1 26 | — | $60.4M | ||
| Q4 25 | $44.7M | $56.4B | ||
| Q3 25 | $34.2M | $57.8B | ||
| Q2 25 | $33.9M | $58.2B | ||
| Q1 25 | $33.6M | $51.2B | ||
| Q4 24 | $33.2M | $49.7B | ||
| Q3 24 | — | $53.5B | ||
| Q2 24 | — | $51.5B |
| Q1 26 | — | $34.0M | ||
| Q4 25 | $-271.1M | $33.5B | ||
| Q3 25 | $-274.1M | $32.4B | ||
| Q2 25 | $-354.6M | $32.3B | ||
| Q1 25 | $-341.8M | $31.2B | ||
| Q4 24 | $-326.4M | $30.3B | ||
| Q3 24 | $-292.3M | $29.7B | ||
| Q2 24 | $-241.3M | $29.5B |
| Q1 26 | — | $308.9M | ||
| Q4 25 | $226.8M | $300.1B | ||
| Q3 25 | $233.9M | $297.6B | ||
| Q2 25 | $185.2M | $295.6B | ||
| Q1 25 | $200.2M | $282.2B | ||
| Q4 24 | $226.3M | $271.5B | ||
| Q3 24 | $238.5M | $271.0B | ||
| Q2 24 | $292.4M | $272.2B |
| Q1 26 | — | 1.78× | ||
| Q4 25 | — | 1.68× | ||
| Q3 25 | — | 1.78× | ||
| Q2 25 | — | 1.80× | ||
| Q1 25 | — | 1.64× | ||
| Q4 24 | — | 1.64× | ||
| Q3 24 | — | 1.80× | ||
| Q2 24 | — | 1.74× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-16.6M | — |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $-16.6M | $3.1B | ||
| Q3 25 | $-14.7M | $6.2B | ||
| Q2 25 | $-20.2M | $4.4B | ||
| Q1 25 | $-25.6M | $4.8B | ||
| Q4 24 | $-28.7M | $5.8B | ||
| Q3 24 | $-53.3M | $-1.8B | ||
| Q2 24 | $-38.2M | $4.5B |
| Q1 26 | — | — | ||
| Q4 25 | — | $2.3B | ||
| Q3 25 | — | $5.6B | ||
| Q2 25 | $-20.2M | $3.7B | ||
| Q1 25 | $-25.6M | $4.3B | ||
| Q4 24 | $-28.7M | $5.3B | ||
| Q3 24 | $-53.3M | $-2.3B | ||
| Q2 24 | $-38.6M | $4.0B |
| Q1 26 | — | — | ||
| Q4 25 | — | 21.4% | ||
| Q3 25 | — | 53.6% | ||
| Q2 25 | -78.7% | 36.3% | ||
| Q1 25 | -106.5% | 45.0% | ||
| Q4 24 | -107.0% | 53.1% | ||
| Q3 24 | -212.2% | -23.3% | ||
| Q2 24 | -164.4% | 40.4% |
| Q1 26 | — | — | ||
| Q4 25 | 0.0% | 6.6% | ||
| Q3 25 | 0.0% | 6.3% | ||
| Q2 25 | 0.0% | 6.0% | ||
| Q1 25 | 0.0% | 4.5% | ||
| Q4 24 | 0.3% | 5.0% | ||
| Q3 24 | 0.0% | 4.7% | ||
| Q2 24 | 2.0% | 5.8% |
| Q1 26 | — | — | ||
| Q4 25 | — | 1.25× | ||
| Q3 25 | -0.23× | 2.15× | ||
| Q2 25 | — | 1.51× | ||
| Q1 25 | — | 1.84× | ||
| Q4 24 | — | 2.66× | ||
| Q3 24 | — | -0.72× | ||
| Q2 24 | — | 1.50× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AGEN
| Non Cash Royalty Revenue | $31.1M | 91% |
| Other | $3.2M | 9% |
AXP
| Discount revenue | $9.5M | 50% |
| Other | $8.9M | 47% |
| Deposits with banks and other | $512.0K | 3% |
