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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and NexPoint Real Estate Finance, Inc. (NREF). Click either name above to swap in a different company.
AGIOS PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($20.0M vs $11.1M, roughly 1.8× NexPoint Real Estate Finance, Inc.). NexPoint Real Estate Finance, Inc. runs the higher net margin — 216.6% vs -541.1%, a 757.7% gap on every dollar of revenue. On growth, AGIOS PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (86.1% vs -48.8%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
NexPoint Real Estate Finance, Inc. is a US-based commercial real estate finance firm that offers structured financing solutions for multifamily, office, industrial, and hospitality properties. It focuses on originating, managing and servicing a diversified portfolio of mortgage loans and real estate-related investments to deliver stable risk-adjusted returns to stakeholders.
AGIO vs NREF — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $11.1M |
| Net Profit | $-108.0M | $24.0M |
| Gross Margin | 90.6% | — |
| Operating Margin | -608.9% | — |
| Net Margin | -541.1% | 216.6% |
| Revenue YoY | 86.1% | -48.8% |
| Net Profit YoY | -11.9% | 58.7% |
| EPS (diluted) | $-1.86 | $0.47 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $11.1M | ||
| Q3 25 | $12.9M | $12.5M | ||
| Q2 25 | $12.5M | $12.1M | ||
| Q1 25 | $8.7M | $11.5M | ||
| Q4 24 | $10.7M | $21.7M | ||
| Q3 24 | $9.0M | $12.5M | ||
| Q2 24 | $8.6M | $6.7M | ||
| Q1 24 | $8.2M | $-12.8M |
| Q4 25 | $-108.0M | $24.0M | ||
| Q3 25 | $-103.4M | $50.9M | ||
| Q2 25 | $-112.0M | $22.3M | ||
| Q1 25 | $-89.3M | $26.0M | ||
| Q4 24 | $-96.5M | $15.2M | ||
| Q3 24 | $947.9M | $23.3M | ||
| Q2 24 | $-96.1M | $12.1M | ||
| Q1 24 | $-81.5M | $-14.6M |
| Q4 25 | 90.6% | — | ||
| Q3 25 | 87.0% | — | ||
| Q2 25 | 86.3% | — | ||
| Q1 25 | 87.6% | — | ||
| Q4 24 | 88.3% | — | ||
| Q3 24 | 91.3% | — | ||
| Q2 24 | 82.6% | — | ||
| Q1 24 | 92.3% | — |
| Q4 25 | -608.9% | — | ||
| Q3 25 | -907.4% | — | ||
| Q2 25 | -1020.1% | — | ||
| Q1 25 | -1222.0% | — | ||
| Q4 24 | -1165.3% | — | ||
| Q3 24 | -1146.9% | — | ||
| Q2 24 | -1228.3% | — | ||
| Q1 24 | -1124.3% | — |
| Q4 25 | -541.1% | 216.6% | ||
| Q3 25 | -803.1% | 407.0% | ||
| Q2 25 | -899.4% | 184.5% | ||
| Q1 25 | -1023.3% | 225.6% | ||
| Q4 24 | -899.6% | 69.9% | ||
| Q3 24 | 10574.7% | 186.4% | ||
| Q2 24 | -1115.7% | 179.7% | ||
| Q1 24 | -995.8% | 114.3% |
| Q4 25 | $-1.86 | $0.47 | ||
| Q3 25 | $-1.78 | $1.14 | ||
| Q2 25 | $-1.93 | $0.54 | ||
| Q1 25 | $-1.55 | $0.70 | ||
| Q4 24 | $-1.44 | $0.71 | ||
| Q3 24 | $16.22 | $0.74 | ||
| Q2 24 | $-1.69 | $0.40 | ||
| Q1 24 | $-1.45 | $-0.83 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | $31.1M |
| Total DebtLower is stronger | — | $771.2M |
| Stockholders' EquityBook value | $1.2B | $388.0M |
| Total Assets | $1.3B | $5.3B |
| Debt / EquityLower = less leverage | — | 1.99× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | $31.1M | ||
| Q3 25 | $92.7M | $17.9M | ||
| Q2 25 | $80.9M | $9.1M | ||
| Q1 25 | $79.0M | $19.2M | ||
| Q4 24 | $76.2M | $3.9M | ||
| Q3 24 | $253.7M | $34.7M | ||
| Q2 24 | $84.5M | $4.3M | ||
| Q1 24 | $118.8M | $13.5M |
| Q4 25 | — | $771.2M | ||
| Q3 25 | — | $720.9M | ||
| Q2 25 | — | $815.6M | ||
| Q1 25 | — | $831.5M | ||
| Q4 24 | — | $799.3M | ||
| Q3 24 | — | $815.5M | ||
| Q2 24 | — | $861.0M | ||
| Q1 24 | — | $843.3M |
| Q4 25 | $1.2B | $388.0M | ||
| Q3 25 | $1.3B | $375.4M | ||
| Q2 25 | $1.4B | $348.2M | ||
| Q1 25 | $1.5B | $343.7M | ||
| Q4 24 | $1.5B | $336.5M | ||
| Q3 24 | $1.6B | $335.8M | ||
| Q2 24 | $660.5M | $327.5M | ||
| Q1 24 | $743.9M | $327.1M |
| Q4 25 | $1.3B | $5.3B | ||
| Q3 25 | $1.4B | $5.3B | ||
| Q2 25 | $1.5B | $5.4B | ||
| Q1 25 | $1.6B | $5.4B | ||
| Q4 24 | $1.7B | $5.4B | ||
| Q3 24 | $1.8B | $5.7B | ||
| Q2 24 | $773.1M | $6.6B | ||
| Q1 24 | $849.7M | $7.1B |
| Q4 25 | — | 1.99× | ||
| Q3 25 | — | 1.92× | ||
| Q2 25 | — | 2.34× | ||
| Q1 25 | — | 2.42× | ||
| Q4 24 | — | 2.38× | ||
| Q3 24 | — | 2.43× | ||
| Q2 24 | — | 2.63× | ||
| Q1 24 | — | 2.58× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $-4.5M |
| Free Cash FlowOCF − Capex | $-97.3M | — |
| FCF MarginFCF / Revenue | -487.5% | — |
| Capex IntensityCapex / Revenue | 5.6% | — |
| Cash ConversionOCF / Net Profit | — | -0.19× |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $-4.5M | ||
| Q3 25 | $-88.2M | $8.1M | ||
| Q2 25 | $-77.1M | $3.3M | ||
| Q1 25 | $-111.5M | $16.0M | ||
| Q4 24 | $-133.2M | $4.4M | ||
| Q3 24 | $-84.2M | $14.7M | ||
| Q2 24 | $-72.6M | $-7.5M | ||
| Q1 24 | $-99.9M | $17.7M |
| Q4 25 | $-97.3M | — | ||
| Q3 25 | $-89.7M | — | ||
| Q2 25 | $-78.0M | — | ||
| Q1 25 | $-112.3M | — | ||
| Q4 24 | $-134.1M | — | ||
| Q3 24 | $-84.6M | — | ||
| Q2 24 | $-72.7M | — | ||
| Q1 24 | $-100.0M | — |
| Q4 25 | -487.5% | — | ||
| Q3 25 | -696.5% | — | ||
| Q2 25 | -626.2% | — | ||
| Q1 25 | -1286.4% | — | ||
| Q4 24 | -1250.1% | — | ||
| Q3 24 | -944.2% | — | ||
| Q2 24 | -844.4% | — | ||
| Q1 24 | -1221.2% | — |
| Q4 25 | 5.6% | — | ||
| Q3 25 | 12.1% | — | ||
| Q2 25 | 7.0% | — | ||
| Q1 25 | 8.8% | — | ||
| Q4 24 | 9.0% | — | ||
| Q3 24 | 4.7% | — | ||
| Q2 24 | 1.8% | — | ||
| Q1 24 | 1.7% | — |
| Q4 25 | — | -0.19× | ||
| Q3 25 | — | 0.16× | ||
| Q2 25 | — | 0.15× | ||
| Q1 25 | — | 0.62× | ||
| Q4 24 | — | 0.29× | ||
| Q3 24 | -0.09× | 0.63× | ||
| Q2 24 | — | -0.62× | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
