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Side-by-side financial comparison of AGIOS PHARMACEUTICALS, INC. (AGIO) and Spok Holdings, Inc (SPOK). Click either name above to swap in a different company.
Spok Holdings, Inc is the larger business by last-quarter revenue ($33.9M vs $20.0M, roughly 1.7× AGIOS PHARMACEUTICALS, INC.). Spok Holdings, Inc runs the higher net margin — 8.7% vs -541.1%, a 549.7% gap on every dollar of revenue. On growth, AGIOS PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (86.1% vs -0.1%). Spok Holdings, Inc produced more free cash flow last quarter ($10.1M vs $-97.3M). Over the past eight quarters, AGIOS PHARMACEUTICALS, INC.'s revenue compounded faster (56.1% CAGR vs -1.5%).
Agios Pharmaceuticals Inc. is a publicly trading American pharmaceutical company pioneering therapies for genetically defined diseases, with a near-term focus on developing therapies for hemolytic anemias. The company was founded in 2008 by Lewis Cantley, Tak Mak and Craig Thompson. Agios is a Delaware corporation headquartered in Cambridge, Massachusetts. The company tendered an initial public offering in July 2013.
Spok Holdings, Inc. is a global provider of critical communication solutions primarily serving the healthcare industry. It offers unified clinical communication platforms, secure messaging tools, alerting systems, and on-call scheduling software that help care teams coordinate efficiently, cut response times, and boost patient safety across medical facilities.
AGIO vs SPOK — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $20.0M | $33.9M |
| Net Profit | $-108.0M | $2.9M |
| Gross Margin | 90.6% | 76.7% |
| Operating Margin | -608.9% | 11.6% |
| Net Margin | -541.1% | 8.7% |
| Revenue YoY | 86.1% | -0.1% |
| Net Profit YoY | -11.9% | -19.6% |
| EPS (diluted) | $-1.86 | $0.13 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $20.0M | $33.9M | ||
| Q3 25 | $12.9M | $33.9M | ||
| Q2 25 | $12.5M | $35.7M | ||
| Q1 25 | $8.7M | $36.3M | ||
| Q4 24 | $10.7M | $33.9M | ||
| Q3 24 | $9.0M | $34.9M | ||
| Q2 24 | $8.6M | $34.0M | ||
| Q1 24 | $8.2M | $34.9M |
| Q4 25 | $-108.0M | $2.9M | ||
| Q3 25 | $-103.4M | $3.2M | ||
| Q2 25 | $-112.0M | $4.6M | ||
| Q1 25 | $-89.3M | $5.2M | ||
| Q4 24 | $-96.5M | $3.6M | ||
| Q3 24 | $947.9M | $3.7M | ||
| Q2 24 | $-96.1M | $3.4M | ||
| Q1 24 | $-81.5M | $4.2M |
| Q4 25 | 90.6% | 76.7% | ||
| Q3 25 | 87.0% | 78.3% | ||
| Q2 25 | 86.3% | 79.5% | ||
| Q1 25 | 87.6% | 80.1% | ||
| Q4 24 | 88.3% | 78.5% | ||
| Q3 24 | 91.3% | 79.5% | ||
| Q2 24 | 82.6% | 78.9% | ||
| Q1 24 | 92.3% | 79.5% |
| Q4 25 | -608.9% | 11.6% | ||
| Q3 25 | -907.4% | 12.9% | ||
| Q2 25 | -1020.1% | 15.1% | ||
| Q1 25 | -1222.0% | 16.6% | ||
| Q4 24 | -1165.3% | 13.7% | ||
| Q3 24 | -1146.9% | 14.2% | ||
| Q2 24 | -1228.3% | 13.2% | ||
| Q1 24 | -1124.3% | 14.0% |
| Q4 25 | -541.1% | 8.7% | ||
| Q3 25 | -803.1% | 9.5% | ||
| Q2 25 | -899.4% | 12.8% | ||
| Q1 25 | -1023.3% | 14.3% | ||
| Q4 24 | -899.6% | 10.8% | ||
| Q3 24 | 10574.7% | 10.5% | ||
| Q2 24 | -1115.7% | 10.1% | ||
| Q1 24 | -995.8% | 12.1% |
| Q4 25 | $-1.86 | $0.13 | ||
| Q3 25 | $-1.78 | $0.15 | ||
| Q2 25 | $-1.93 | $0.22 | ||
| Q1 25 | $-1.55 | $0.25 | ||
| Q4 24 | $-1.44 | $0.17 | ||
| Q3 24 | $16.22 | $0.18 | ||
| Q2 24 | $-1.69 | $0.17 | ||
| Q1 24 | $-1.45 | $0.21 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $89.1M | $25.3M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $146.4M |
| Total Assets | $1.3B | $206.1M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $89.1M | $25.3M | ||
| Q3 25 | $92.7M | $21.4M | ||
| Q2 25 | $80.9M | $20.2M | ||
| Q1 25 | $79.0M | $19.9M | ||
| Q4 24 | $76.2M | $29.1M | ||
| Q3 24 | $253.7M | $27.8M | ||
| Q2 24 | $84.5M | $23.9M | ||
| Q1 24 | $118.8M | $23.3M |
| Q4 25 | $1.2B | $146.4M | ||
| Q3 25 | $1.3B | $148.7M | ||
| Q2 25 | $1.4B | $150.9M | ||
| Q1 25 | $1.5B | $151.7M | ||
| Q4 24 | $1.5B | $154.7M | ||
| Q3 24 | $1.6B | $156.3M | ||
| Q2 24 | $660.5M | $158.2M | ||
| Q1 24 | $743.9M | $160.2M |
| Q4 25 | $1.3B | $206.1M | ||
| Q3 25 | $1.4B | $209.7M | ||
| Q2 25 | $1.5B | $208.7M | ||
| Q1 25 | $1.6B | $204.5M | ||
| Q4 24 | $1.7B | $217.1M | ||
| Q3 24 | $1.8B | $216.8M | ||
| Q2 24 | $773.1M | $216.4M | ||
| Q1 24 | $849.7M | $215.0M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.2M | $11.5M |
| Free Cash FlowOCF − Capex | $-97.3M | $10.1M |
| FCF MarginFCF / Revenue | -487.5% | 29.9% |
| Capex IntensityCapex / Revenue | 5.6% | 4.1% |
| Cash ConversionOCF / Net Profit | — | 3.93× |
| TTM Free Cash FlowTrailing 4 quarters | $-377.3M | $25.2M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.2M | $11.5M | ||
| Q3 25 | $-88.2M | $8.1M | ||
| Q2 25 | $-77.1M | $7.0M | ||
| Q1 25 | $-111.5M | $2.3M | ||
| Q4 24 | $-133.2M | $8.4M | ||
| Q3 24 | $-84.2M | $11.1M | ||
| Q2 24 | $-72.6M | $7.4M | ||
| Q1 24 | $-99.9M | $2.0M |
| Q4 25 | $-97.3M | $10.1M | ||
| Q3 25 | $-89.7M | $7.6M | ||
| Q2 25 | $-78.0M | $6.0M | ||
| Q1 25 | $-112.3M | $1.5M | ||
| Q4 24 | $-134.1M | $7.5M | ||
| Q3 24 | $-84.6M | $10.3M | ||
| Q2 24 | $-72.7M | $6.8M | ||
| Q1 24 | $-100.0M | $1.1M |
| Q4 25 | -487.5% | 29.9% | ||
| Q3 25 | -696.5% | 22.4% | ||
| Q2 25 | -626.2% | 16.8% | ||
| Q1 25 | -1286.4% | 4.2% | ||
| Q4 24 | -1250.1% | 22.3% | ||
| Q3 24 | -944.2% | 29.4% | ||
| Q2 24 | -844.4% | 20.0% | ||
| Q1 24 | -1221.2% | 3.2% |
| Q4 25 | 5.6% | 4.1% | ||
| Q3 25 | 12.1% | 1.6% | ||
| Q2 25 | 7.0% | 2.9% | ||
| Q1 25 | 8.8% | 2.1% | ||
| Q4 24 | 9.0% | 2.5% | ||
| Q3 24 | 4.7% | 2.4% | ||
| Q2 24 | 1.8% | 1.9% | ||
| Q1 24 | 1.7% | 2.5% |
| Q4 25 | — | 3.93× | ||
| Q3 25 | — | 2.54× | ||
| Q2 25 | — | 1.55× | ||
| Q1 25 | — | 0.43× | ||
| Q4 24 | — | 2.31× | ||
| Q3 24 | -0.09× | 3.03× | ||
| Q2 24 | — | 2.17× | ||
| Q1 24 | — | 0.47× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AGIO
Segment breakdown not available.
SPOK
| Paging | $16.8M | 50% |
| Software Operations | $16.0M | 47% |
| License | $1.2M | 4% |
