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Side-by-side financial comparison of American Express (AXP) and Personalis, Inc. (PSNL). Click either name above to swap in a different company.
American Express is the larger business by last-quarter revenue ($18.9M vs $17.3M, roughly 1.1× Personalis, Inc.). American Express runs the higher net margin — 15.7% vs -137.3%, a 153.0% gap on every dollar of revenue. On growth, American Express posted the faster year-over-year revenue change (11.4% vs 3.2%). Over the past eight quarters, Personalis, Inc.'s revenue compounded faster (-5.7% CAGR vs -95.6%).
American Express Company, together with its subsidiaries, provides charge and credit payment card products, and travel-related services worldwide. The company operates through three segments: Global Consumer Services Group, Global Commercial Services, and Global Merchant and Network Services. Its products and services include payment and financing products; network services; accounts payable expense management products and services; and travel and lifestyle services. The company's products an...
Personalis, Inc. is a precision medicine company specializing in advanced oncology genomics solutions. It develops proprietary genomic sequencing and data analytics platforms to support biopharmaceutical partners in immunotherapy development and clinical providers in delivering personalized cancer care, with operations spanning North America, Europe and key Asia-Pacific markets.
AXP vs PSNL — Head-to-Head
Income Statement — Q1 FY2026 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $18.9M | $17.3M |
| Net Profit | $3.0M | $-23.8M |
| Gross Margin | — | 11.0% |
| Operating Margin | — | -145.7% |
| Net Margin | 15.7% | -137.3% |
| Revenue YoY | 11.4% | 3.2% |
| Net Profit YoY | 15.0% | -45.0% |
| EPS (diluted) | — | $-0.26 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | $18.9M | — | ||
| Q4 25 | $10.9B | $17.3M | ||
| Q3 25 | $10.4B | $14.5M | ||
| Q2 25 | $10.3B | $17.2M | ||
| Q1 25 | $9.6B | $20.6M | ||
| Q4 24 | $10.0B | $16.8M | ||
| Q3 24 | $9.7B | $25.7M | ||
| Q2 24 | $9.8B | $22.6M |
| Q1 26 | $3.0M | — | ||
| Q4 25 | $2.5B | $-23.8M | ||
| Q3 25 | $2.9B | $-21.7M | ||
| Q2 25 | $2.9B | $-20.1M | ||
| Q1 25 | $2.6B | $-15.8M | ||
| Q4 24 | $2.2B | $-16.4M | ||
| Q3 24 | $2.5B | $-39.1M | ||
| Q2 24 | $3.0B | $-12.8M |
| Q1 26 | — | — | ||
| Q4 25 | — | 11.0% | ||
| Q3 25 | — | 13.2% | ||
| Q2 25 | — | 27.6% | ||
| Q1 25 | — | 35.0% | ||
| Q4 24 | — | 27.1% | ||
| Q3 24 | — | 34.0% | ||
| Q2 24 | — | 35.6% |
| Q1 26 | — | — | ||
| Q4 25 | 28.2% | -145.7% | ||
| Q3 25 | 36.7% | -160.7% | ||
| Q2 25 | 34.4% | -126.7% | ||
| Q1 25 | 34.6% | -85.9% | ||
| Q4 24 | 27.7% | -107.8% | ||
| Q3 24 | 33.0% | -55.9% | ||
| Q2 24 | 38.6% | -74.8% |
| Q1 26 | 15.7% | — | ||
| Q4 25 | 22.5% | -137.3% | ||
| Q3 25 | 27.9% | -149.4% | ||
| Q2 25 | 28.0% | -116.6% | ||
| Q1 25 | 26.8% | -76.4% | ||
| Q4 24 | 21.8% | -97.8% | ||
| Q3 24 | 25.8% | -152.0% | ||
| Q2 24 | 30.7% | -56.7% |
| Q1 26 | — | — | ||
| Q4 25 | $3.52 | $-0.26 | ||
| Q3 25 | $4.14 | $-0.24 | ||
| Q2 25 | $4.08 | $-0.23 | ||
| Q1 25 | $3.64 | $-0.18 | ||
| Q4 24 | $3.04 | $-0.23 | ||
| Q3 24 | $3.49 | $-0.64 | ||
| Q2 24 | $4.15 | $-0.24 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | — | $240.0M |
| Total DebtLower is stronger | $60.4M | — |
| Stockholders' EquityBook value | $34.0M | $261.2M |
| Total Assets | $308.9M | $334.2M |
| Debt / EquityLower = less leverage | 1.78× | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $742.0M | $240.0M | ||
| Q3 25 | $1.3B | $150.5M | ||
| Q2 25 | $197.0M | $173.2M | ||
| Q1 25 | $261.0M | $185.7M | ||
| Q4 24 | $221.0M | $185.0M | ||
| Q3 24 | $120.0M | $143.7M | ||
| Q2 24 | $188.0M | $87.0M |
| Q1 26 | $60.4M | — | ||
| Q4 25 | $56.4B | — | ||
| Q3 25 | $57.8B | — | ||
| Q2 25 | $58.2B | — | ||
| Q1 25 | $51.2B | — | ||
| Q4 24 | $49.7B | — | ||
| Q3 24 | $53.5B | — | ||
| Q2 24 | $51.5B | — |
| Q1 26 | $34.0M | — | ||
| Q4 25 | $33.5B | $261.2M | ||
| Q3 25 | $32.4B | $171.4M | ||
| Q2 25 | $32.3B | $190.8M | ||
| Q1 25 | $31.2B | $207.3M | ||
| Q4 24 | $30.3B | $203.0M | ||
| Q3 24 | $29.7B | $166.8M | ||
| Q2 24 | $29.5B | $112.3M |
| Q1 26 | $308.9M | — | ||
| Q4 25 | $300.1B | $334.2M | ||
| Q3 25 | $297.6B | $242.8M | ||
| Q2 25 | $295.6B | $258.7M | ||
| Q1 25 | $282.2B | $273.3M | ||
| Q4 24 | $271.5B | $270.3M | ||
| Q3 24 | $271.0B | $239.9M | ||
| Q2 24 | $272.2B | $185.5M |
| Q1 26 | 1.78× | — | ||
| Q4 25 | 1.68× | — | ||
| Q3 25 | 1.78× | — | ||
| Q2 25 | 1.80× | — | ||
| Q1 25 | 1.64× | — | ||
| Q4 24 | 1.64× | — | ||
| Q3 24 | 1.80× | — | ||
| Q2 24 | 1.74× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | — | $-22.2M |
| Free Cash FlowOCF − Capex | — | $-22.3M |
| FCF MarginFCF / Revenue | — | -128.7% |
| Capex IntensityCapex / Revenue | — | 0.4% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-79.5M |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $3.1B | $-22.2M | ||
| Q3 25 | $6.2B | $-21.8M | ||
| Q2 25 | $4.4B | $-12.9M | ||
| Q1 25 | $4.8B | $-18.0M | ||
| Q4 24 | $5.8B | $-7.8M | ||
| Q3 24 | $-1.8B | $-6.2M | ||
| Q2 24 | $4.5B | $-10.7M |
| Q1 26 | — | — | ||
| Q4 25 | $2.3B | $-22.3M | ||
| Q3 25 | $5.6B | $-23.4M | ||
| Q2 25 | $3.7B | $-13.2M | ||
| Q1 25 | $4.3B | $-20.5M | ||
| Q4 24 | $5.3B | $-9.0M | ||
| Q3 24 | $-2.3B | $-6.4M | ||
| Q2 24 | $4.0B | $-10.7M |
| Q1 26 | — | — | ||
| Q4 25 | 21.4% | -128.7% | ||
| Q3 25 | 53.6% | -161.6% | ||
| Q2 25 | 36.3% | -76.9% | ||
| Q1 25 | 45.0% | -99.4% | ||
| Q4 24 | 53.1% | -53.8% | ||
| Q3 24 | -23.3% | -25.1% | ||
| Q2 24 | 40.4% | -47.6% |
| Q1 26 | — | — | ||
| Q4 25 | 6.6% | 0.4% | ||
| Q3 25 | 6.3% | 11.2% | ||
| Q2 25 | 6.0% | 1.7% | ||
| Q1 25 | 4.5% | 12.2% | ||
| Q4 24 | 5.0% | 7.4% | ||
| Q3 24 | 4.7% | 1.0% | ||
| Q2 24 | 5.8% | 0.0% |
| Q1 26 | — | — | ||
| Q4 25 | 1.25× | — | ||
| Q3 25 | 2.15× | — | ||
| Q2 25 | 1.51× | — | ||
| Q1 25 | 1.84× | — | ||
| Q4 24 | 2.66× | — | ||
| Q3 24 | -0.72× | — | ||
| Q2 24 | 1.50× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AXP
| Discount revenue | $9.5M | 50% |
| Other | $8.9M | 47% |
| Deposits with banks and other | $512.0K | 3% |
PSNL
| Population Sequencing | $11.8M | 68% |
| Related Party | $5.4M | 31% |
