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Side-by-side financial comparison of AYTU BIOPHARMA, INC (AYTU) and NexPoint Real Estate Finance, Inc. (NREF). Click either name above to swap in a different company.

AYTU BIOPHARMA, INC is the larger business by last-quarter revenue ($15.2M vs $11.1M, roughly 1.4× NexPoint Real Estate Finance, Inc.). NexPoint Real Estate Finance, Inc. runs the higher net margin — 216.6% vs -69.8%, a 286.4% gap on every dollar of revenue. On growth, AYTU BIOPHARMA, INC posted the faster year-over-year revenue change (-6.5% vs -48.8%).

Aytu BioPharma, Inc. is a US-based specialty pharmaceutical company that develops and commercializes a portfolio of consumer healthcare products and prescription therapeutics. Its key offerings cover cold and allergy treatments, sexual health solutions, and therapies for rare pediatric conditions, serving patients and healthcare providers across the United States.

NexPoint Real Estate Finance, Inc. is a US-based commercial real estate finance firm that offers structured financing solutions for multifamily, office, industrial, and hospitality properties. It focuses on originating, managing and servicing a diversified portfolio of mortgage loans and real estate-related investments to deliver stable risk-adjusted returns to stakeholders.

AYTU vs NREF — Head-to-Head

Bigger by revenue
AYTU
AYTU
1.4× larger
AYTU
$15.2M
$11.1M
NREF
Growing faster (revenue YoY)
AYTU
AYTU
+42.3% gap
AYTU
-6.5%
-48.8%
NREF
Higher net margin
NREF
NREF
286.4% more per $
NREF
216.6%
-69.8%
AYTU

Income Statement — Q2 FY2026 vs Q4 FY2025

Metric
AYTU
AYTU
NREF
NREF
Revenue
$15.2M
$11.1M
Net Profit
$-10.6M
$24.0M
Gross Margin
63.5%
Operating Margin
-13.0%
Net Margin
-69.8%
216.6%
Revenue YoY
-6.5%
-48.8%
Net Profit YoY
-1443.1%
58.7%
EPS (diluted)
$-1.05
$0.47

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
AYTU
AYTU
NREF
NREF
Q4 25
$15.2M
$11.1M
Q3 25
$13.9M
$12.5M
Q2 25
$15.1M
$12.1M
Q1 25
$18.5M
$11.5M
Q4 24
$16.2M
$21.7M
Q3 24
$16.6M
$12.5M
Q2 24
$14.6M
$6.7M
Q1 24
$14.0M
$-12.8M
Net Profit
AYTU
AYTU
NREF
NREF
Q4 25
$-10.6M
$24.0M
Q3 25
$2.0M
$50.9M
Q2 25
$-19.8M
$22.3M
Q1 25
$4.0M
$26.0M
Q4 24
$788.0K
$15.2M
Q3 24
$1.5M
$23.3M
Q2 24
$-4.6M
$12.1M
Q1 24
$-2.9M
$-14.6M
Gross Margin
AYTU
AYTU
NREF
NREF
Q4 25
63.5%
Q3 25
66.1%
Q2 25
67.8%
Q1 25
69.4%
Q4 24
66.5%
Q3 24
72.3%
Q2 24
75.7%
Q1 24
73.9%
Operating Margin
AYTU
AYTU
NREF
NREF
Q4 25
-13.0%
Q3 25
-10.8%
Q2 25
-50.4%
Q1 25
13.1%
Q4 24
-10.4%
Q3 24
-5.6%
Q2 24
-15.6%
Q1 24
-11.4%
Net Margin
AYTU
AYTU
NREF
NREF
Q4 25
-69.8%
216.6%
Q3 25
14.1%
407.0%
Q2 25
-130.9%
184.5%
Q1 25
21.6%
225.6%
Q4 24
4.9%
69.9%
Q3 24
8.9%
186.4%
Q2 24
-31.6%
179.7%
Q1 24
-20.6%
114.3%
EPS (diluted)
AYTU
AYTU
NREF
NREF
Q4 25
$-1.05
$0.47
Q3 25
$-0.08
$1.14
Q2 25
$0.54
Q1 25
$0.21
$0.70
Q4 24
$-0.26
$0.71
Q3 24
$-0.15
$0.74
Q2 24
$0.40
Q1 24
$-0.52
$-0.83

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
AYTU
AYTU
NREF
NREF
Cash + ST InvestmentsLiquidity on hand
$30.0M
$31.1M
Total DebtLower is stronger
$10.0M
$771.2M
Stockholders' EquityBook value
$14.2M
$388.0M
Total Assets
$122.0M
$5.3B
Debt / EquityLower = less leverage
0.70×
1.99×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
AYTU
AYTU
NREF
NREF
Q4 25
$30.0M
$31.1M
Q3 25
$32.6M
$17.9M
Q2 25
$31.0M
$9.1M
Q1 25
$18.2M
$19.2M
Q4 24
$20.4M
$3.9M
Q3 24
$20.1M
$34.7M
Q2 24
$20.0M
$4.3M
Q1 24
$19.8M
$13.5M
Total Debt
AYTU
AYTU
NREF
NREF
Q4 25
$10.0M
$771.2M
Q3 25
$10.4M
$720.9M
Q2 25
$10.9M
$815.6M
Q1 25
$9.5M
$831.5M
Q4 24
$10.0M
$799.3M
Q3 24
$10.4M
$815.5M
Q2 24
$10.9M
$861.0M
Q1 24
$0
$843.3M
Stockholders' Equity
AYTU
AYTU
NREF
NREF
Q4 25
$14.2M
$388.0M
Q3 25
$23.2M
$375.4M
Q2 25
$19.0M
$348.2M
Q1 25
$34.9M
$343.7M
Q4 24
$30.8M
$336.5M
Q3 24
$29.8M
$335.8M
Q2 24
$27.7M
$327.5M
Q1 24
$30.8M
$327.1M
Total Assets
AYTU
AYTU
NREF
NREF
Q4 25
$122.0M
$5.3B
Q3 25
$125.0M
$5.3B
Q2 25
$124.2M
$5.4B
Q1 25
$124.2M
$5.4B
Q4 24
$116.2M
$5.4B
Q3 24
$115.8M
$5.7B
Q2 24
$118.1M
$6.6B
Q1 24
$128.9M
$7.1B
Debt / Equity
AYTU
AYTU
NREF
NREF
Q4 25
0.70×
1.99×
Q3 25
0.45×
1.92×
Q2 25
0.57×
2.34×
Q1 25
0.27×
2.42×
Q4 24
0.32×
2.38×
Q3 24
0.35×
2.43×
Q2 24
0.39×
2.63×
Q1 24
0.00×
2.58×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
AYTU
AYTU
NREF
NREF
Operating Cash FlowLast quarter
$3.7M
$-4.5M
Free Cash FlowOCF − Capex
$3.7M
FCF MarginFCF / Revenue
24.1%
Capex IntensityCapex / Revenue
0.1%
Cash ConversionOCF / Net Profit
-0.19×
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
AYTU
AYTU
NREF
NREF
Q4 25
$3.7M
$-4.5M
Q3 25
$-618.0K
$8.1M
Q2 25
$2.8M
$3.3M
Q1 25
$-6.5M
$16.0M
Q4 24
$2.9M
$4.4M
Q3 24
$-1.2M
$14.7M
Q2 24
$-788.0K
$-7.5M
Q1 24
$-254.0K
$17.7M
Free Cash Flow
AYTU
AYTU
NREF
NREF
Q4 25
$3.7M
Q3 25
Q2 25
Q1 25
$-6.5M
Q4 24
$2.9M
Q3 24
$-1.3M
Q2 24
Q1 24
FCF Margin
AYTU
AYTU
NREF
NREF
Q4 25
24.1%
Q3 25
Q2 25
Q1 25
-35.4%
Q4 24
17.9%
Q3 24
-8.0%
Q2 24
Q1 24
Capex Intensity
AYTU
AYTU
NREF
NREF
Q4 25
0.1%
Q3 25
0.0%
Q2 25
Q1 25
0.4%
Q4 24
0.0%
Q3 24
0.8%
Q2 24
Q1 24
0.0%
Cash Conversion
AYTU
AYTU
NREF
NREF
Q4 25
-0.19×
Q3 25
-0.31×
0.16×
Q2 25
0.15×
Q1 25
-1.62×
0.62×
Q4 24
3.69×
0.29×
Q3 24
-0.81×
0.63×
Q2 24
-0.62×
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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