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Side-by-side financial comparison of COMERICA INC (CMA) and HALOZYME THERAPEUTICS, INC. (HALO). Click either name above to swap in a different company.
COMERICA INC is the larger business by last-quarter revenue ($838.0M vs $451.8M, roughly 1.9× HALOZYME THERAPEUTICS, INC.). COMERICA INC runs the higher net margin — 21.0% vs -31.3%, a 52.3% gap on every dollar of revenue. On growth, HALOZYME THERAPEUTICS, INC. posted the faster year-over-year revenue change (51.6% vs 3.3%). Over the past eight quarters, COMERICA INC's revenue compounded faster (108.9% CAGR vs 51.9%).
Comerica Incorporated is an American financial services company, headquartered in Dallas, Texas. It is the parent of Comerica Bank, a regional commercial bank with 413 branches in the U.S. states of Texas, Michigan, California, Florida and Arizona. Comerica is among the largest U.S. financial holding companies, with offices in a number of U.S. cities.
Halozyme Therapeutics, Inc. is an American biotechnology company. It develops oncology therapies designed to target the tumor microenvironment.
CMA vs HALO — Head-to-Head
Income Statement — Q3 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $838.0M | $451.8M |
| Net Profit | $176.0M | $-141.6M |
| Gross Margin | — | 82.6% |
| Operating Margin | — | -20.6% |
| Net Margin | 21.0% | -31.3% |
| Revenue YoY | 3.3% | 51.6% |
| Net Profit YoY | -4.3% | -203.3% |
| EPS (diluted) | $1.35 | $-1.13 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $451.8M | ||
| Q3 25 | $838.0M | $354.3M | ||
| Q2 25 | $849.0M | $325.7M | ||
| Q1 25 | $829.0M | $264.9M | ||
| Q4 24 | $825.0M | $298.0M | ||
| Q3 24 | $811.0M | $290.1M | ||
| Q2 24 | $824.0M | $231.4M | ||
| Q1 24 | $784.0M | $195.9M |
| Q4 25 | — | $-141.6M | ||
| Q3 25 | $176.0M | $175.2M | ||
| Q2 25 | $199.0M | $165.2M | ||
| Q1 25 | $172.0M | $118.1M | ||
| Q4 24 | $170.0M | $137.0M | ||
| Q3 24 | $184.0M | $137.0M | ||
| Q2 24 | $206.0M | $93.2M | ||
| Q1 24 | $138.0M | $76.8M |
| Q4 25 | — | 82.6% | ||
| Q3 25 | — | 84.4% | ||
| Q2 25 | — | 85.8% | ||
| Q1 25 | — | 81.7% | ||
| Q4 24 | — | 85.9% | ||
| Q3 24 | — | 83.0% | ||
| Q2 24 | — | 82.9% | ||
| Q1 24 | — | 85.5% |
| Q4 25 | — | -20.6% | ||
| Q3 25 | — | 61.5% | ||
| Q2 25 | — | 62.2% | ||
| Q1 25 | — | 53.4% | ||
| Q4 24 | — | 58.9% | ||
| Q3 24 | — | 56.3% | ||
| Q2 24 | — | 50.7% | ||
| Q1 24 | — | 48.8% |
| Q4 25 | — | -31.3% | ||
| Q3 25 | 21.0% | 49.5% | ||
| Q2 25 | 23.4% | 50.7% | ||
| Q1 25 | 20.7% | 44.6% | ||
| Q4 24 | 20.6% | 46.0% | ||
| Q3 24 | 22.7% | 47.2% | ||
| Q2 24 | 25.0% | 40.3% | ||
| Q1 24 | 17.6% | 39.2% |
| Q4 25 | — | $-1.13 | ||
| Q3 25 | $1.35 | $1.43 | ||
| Q2 25 | $1.42 | $1.33 | ||
| Q1 25 | $1.25 | $0.93 | ||
| Q4 24 | $1.22 | $1.06 | ||
| Q3 24 | $1.33 | $1.05 | ||
| Q2 24 | $1.49 | $0.72 | ||
| Q1 24 | $0.98 | $0.60 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | — | $133.8M |
| Total DebtLower is stronger | $5.4B | $2.1B |
| Stockholders' EquityBook value | $7.4B | $48.8M |
| Total Assets | $77.4B | $2.5B |
| Debt / EquityLower = less leverage | 0.73× | 43.89× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $133.8M | ||
| Q3 25 | — | $419.7M | ||
| Q2 25 | — | $61.9M | ||
| Q1 25 | — | $176.3M | ||
| Q4 24 | — | $115.8M | ||
| Q3 24 | — | $154.3M | ||
| Q2 24 | — | $187.9M | ||
| Q1 24 | — | $164.6M |
| Q4 25 | — | $2.1B | ||
| Q3 25 | $5.4B | $1.5B | ||
| Q2 25 | $5.8B | $1.5B | ||
| Q1 25 | $5.7B | $1.5B | ||
| Q4 24 | $6.7B | $1.5B | ||
| Q3 24 | $6.8B | $1.5B | ||
| Q2 24 | $7.1B | $1.5B | ||
| Q1 24 | $7.1B | $1.5B |
| Q4 25 | — | $48.8M | ||
| Q3 25 | $7.4B | $503.9M | ||
| Q2 25 | $6.9B | $332.7M | ||
| Q1 25 | $7.1B | $482.3M | ||
| Q4 24 | $6.5B | $363.8M | ||
| Q3 24 | $7.4B | $452.7M | ||
| Q2 24 | $6.2B | $289.4M | ||
| Q1 24 | $6.0B | $177.8M |
| Q4 25 | — | $2.5B | ||
| Q3 25 | $77.4B | $2.2B | ||
| Q2 25 | $78.0B | $2.1B | ||
| Q1 25 | $77.6B | $2.2B | ||
| Q4 24 | $79.3B | $2.1B | ||
| Q3 24 | $79.7B | $2.1B | ||
| Q2 24 | $79.6B | $2.0B | ||
| Q1 24 | $79.4B | $1.8B |
| Q4 25 | — | 43.89× | ||
| Q3 25 | 0.73× | 3.00× | ||
| Q2 25 | 0.84× | 4.54× | ||
| Q1 25 | 0.81× | 3.13× | ||
| Q4 24 | 1.02× | 4.14× | ||
| Q3 24 | 0.92× | 3.32× | ||
| Q2 24 | 1.15× | 5.19× | ||
| Q1 24 | 1.18× | 8.44× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-270.0M | $219.0M |
| Free Cash FlowOCF − Capex | — | $217.6M |
| FCF MarginFCF / Revenue | — | 48.2% |
| Capex IntensityCapex / Revenue | — | 0.3% |
| Cash ConversionOCF / Net Profit | -1.53× | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $644.6M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $219.0M | ||
| Q3 25 | $-270.0M | $178.6M | ||
| Q2 25 | $476.0M | $99.7M | ||
| Q1 25 | $273.0M | $154.2M | ||
| Q4 24 | $601.0M | $178.5M | ||
| Q3 24 | $1.0B | $115.4M | ||
| Q2 24 | $111.0M | $55.8M | ||
| Q1 24 | $-205.0M | $129.4M |
| Q4 25 | — | $217.6M | ||
| Q3 25 | — | $175.6M | ||
| Q2 25 | — | $98.1M | ||
| Q1 25 | — | $153.3M | ||
| Q4 24 | — | $175.4M | ||
| Q3 24 | — | $113.9M | ||
| Q2 24 | — | $53.2M | ||
| Q1 24 | — | $125.9M |
| Q4 25 | — | 48.2% | ||
| Q3 25 | — | 49.6% | ||
| Q2 25 | — | 30.1% | ||
| Q1 25 | — | 57.9% | ||
| Q4 24 | — | 58.9% | ||
| Q3 24 | — | 39.3% | ||
| Q2 24 | — | 23.0% | ||
| Q1 24 | — | 64.3% |
| Q4 25 | — | 0.3% | ||
| Q3 25 | — | 0.9% | ||
| Q2 25 | — | 0.5% | ||
| Q1 25 | — | 0.4% | ||
| Q4 24 | — | 1.0% | ||
| Q3 24 | — | 0.5% | ||
| Q2 24 | — | 1.1% | ||
| Q1 24 | — | 1.8% |
| Q4 25 | — | — | ||
| Q3 25 | -1.53× | 1.02× | ||
| Q2 25 | 2.39× | 0.60× | ||
| Q1 25 | 1.59× | 1.31× | ||
| Q4 24 | 3.54× | 1.30× | ||
| Q3 24 | 5.70× | 0.84× | ||
| Q2 24 | 0.54× | 0.60× | ||
| Q1 24 | -1.49× | 1.68× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CMA
Segment breakdown not available.
HALO
| Royalty | $258.0M | 57% |
| Products | $122.7M | 27% |
| Proprietary Products Sales | $59.6M | 13% |
| Device Partnered Products | $12.9M | 3% |
