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Side-by-side financial comparison of Cue Biopharma, Inc. (CUE) and Usio, Inc. (USIO). Click either name above to swap in a different company.
Usio, Inc. is the larger business by last-quarter revenue ($22.2M vs $21.9M, roughly 1.0× Cue Biopharma, Inc.). Cue Biopharma, Inc. runs the higher net margin — 7.2% vs -6.7%, a 13.9% gap on every dollar of revenue. On growth, Cue Biopharma, Inc. posted the faster year-over-year revenue change (1292.3% vs 8.2%). Over the past eight quarters, Cue Biopharma, Inc.'s revenue compounded faster (257.5% CAGR vs 3.0%).
Cue Biopharma is a clinical-stage biotechnology company focused on developing novel targeted immunotherapies for cancer, autoimmune disorders, and inflammatory diseases. Its proprietary platform enables precise T-cell activity modulation, with core operations in North America and global pharma partnerships to advance lead product candidates through clinical trials.
Usio, Inc. is an American financial technology company headquartered in San Antonio, Texas. It provides integrated electronic payment services, including ACH processing, credit card and debit card acceptance, payment facilitation for software platforms, prepaid card issuing and a document print and mail operation.
CUE vs USIO — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $21.9M | $22.2M |
| Net Profit | $1.6M | $-1.5M |
| Gross Margin | — | 21.9% |
| Operating Margin | 9.0% | -5.7% |
| Net Margin | 7.2% | -6.7% |
| Revenue YoY | 1292.3% | 8.2% |
| Net Profit YoY | 116.7% | -337.8% |
| EPS (diluted) | $0.05 | $-0.05 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $21.9M | $22.2M | ||
| Q3 25 | $2.1M | $21.2M | ||
| Q2 25 | $3.0M | $20.0M | ||
| Q1 25 | $421.0K | $22.0M | ||
| Q4 24 | $1.6M | $20.6M | ||
| Q3 24 | $3.3M | $21.3M | ||
| Q2 24 | $2.7M | $20.1M | ||
| Q1 24 | $1.7M | $21.0M |
| Q4 25 | $1.6M | $-1.5M | ||
| Q3 25 | $-7.4M | $-415.1K | ||
| Q2 25 | $-8.5M | $-366.7K | ||
| Q1 25 | $-12.3M | $-235.0K | ||
| Q4 24 | — | $628.9K | ||
| Q3 24 | $-8.7M | $2.9M | ||
| Q2 24 | $-10.2M | $75.5K | ||
| Q1 24 | $-12.3M | $-250.2K |
| Q4 25 | — | 21.9% | ||
| Q3 25 | — | 23.0% | ||
| Q2 25 | — | 25.8% | ||
| Q1 25 | — | 21.9% | ||
| Q4 24 | — | 24.6% | ||
| Q3 24 | — | 23.0% | ||
| Q2 24 | — | 23.9% | ||
| Q1 24 | — | 23.1% |
| Q4 25 | 9.0% | -5.7% | ||
| Q3 25 | -353.4% | -2.2% | ||
| Q2 25 | -292.3% | -2.0% | ||
| Q1 25 | -2921.4% | -1.1% | ||
| Q4 24 | — | -2.9% | ||
| Q3 24 | -264.2% | -1.8% | ||
| Q2 24 | -390.6% | -1.0% | ||
| Q1 24 | -737.8% | -1.3% |
| Q4 25 | 7.2% | -6.7% | ||
| Q3 25 | -346.6% | -2.0% | ||
| Q2 25 | -287.1% | -1.8% | ||
| Q1 25 | -2911.4% | -1.1% | ||
| Q4 24 | — | 3.1% | ||
| Q3 24 | -259.6% | 13.4% | ||
| Q2 24 | -382.7% | 0.4% | ||
| Q1 24 | -719.1% | -1.2% |
| Q4 25 | $0.05 | $-0.05 | ||
| Q3 25 | $-0.07 | $-0.02 | ||
| Q2 25 | $-0.09 | $-0.01 | ||
| Q1 25 | $-0.17 | $-0.01 | ||
| Q4 24 | — | $0.03 | ||
| Q3 24 | $-0.17 | $0.10 | ||
| Q2 24 | $-0.20 | $0.00 | ||
| Q1 24 | $-0.25 | $-0.01 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $27.1M | $7.4M |
| Total DebtLower is stronger | — | $1.4M |
| Stockholders' EquityBook value | $26.4M | $17.9M |
| Total Assets | $42.2M | $134.9M |
| Debt / EquityLower = less leverage | — | 0.08× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $27.1M | $7.4M | ||
| Q3 25 | $11.7M | $7.7M | ||
| Q2 25 | $27.5M | $8.1M | ||
| Q1 25 | $13.1M | $8.7M | ||
| Q4 24 | $22.5M | $8.1M | ||
| Q3 24 | $32.4M | $8.4M | ||
| Q2 24 | $30.0M | $7.2M | ||
| Q1 24 | $41.0M | $7.1M |
| Q4 25 | — | $1.4M | ||
| Q3 25 | — | $836.7K | ||
| Q2 25 | — | $647.1K | ||
| Q1 25 | — | $683.3K | ||
| Q4 24 | — | $719.4K | ||
| Q3 24 | $1.0M | $562.9K | ||
| Q2 24 | $2.0M | $597.2K | ||
| Q1 24 | $3.0M | $630.9K |
| Q4 25 | $26.4M | $17.9M | ||
| Q3 25 | $13.2M | $18.7M | ||
| Q2 25 | $18.2M | $18.7M | ||
| Q1 25 | $6.6M | $19.0M | ||
| Q4 24 | $17.5M | $19.2M | ||
| Q3 24 | $25.4M | $18.9M | ||
| Q2 24 | $21.6M | $15.7M | ||
| Q1 24 | $30.0M | $15.3M |
| Q4 25 | $42.2M | $134.9M | ||
| Q3 25 | $31.6M | $99.4M | ||
| Q2 25 | $40.7M | $108.4M | ||
| Q1 25 | $22.3M | $109.6M | ||
| Q4 24 | $32.2M | $107.2M | ||
| Q3 24 | $44.8M | $114.6M | ||
| Q2 24 | $42.3M | $108.8M | ||
| Q1 24 | $54.0M | $99.1M |
| Q4 25 | — | 0.08× | ||
| Q3 25 | — | 0.04× | ||
| Q2 25 | — | 0.03× | ||
| Q1 25 | — | 0.04× | ||
| Q4 24 | — | 0.04× | ||
| Q3 24 | 0.04× | 0.03× | ||
| Q2 24 | 0.09× | 0.04× | ||
| Q1 24 | 0.10× | 0.04× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-1.1M | $1.5M |
| Free Cash FlowOCF − Capex | — | $1.1M |
| FCF MarginFCF / Revenue | — | 4.8% |
| Capex IntensityCapex / Revenue | 0.0% | 2.0% |
| Cash ConversionOCF / Net Profit | -0.68× | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $1.7M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-1.1M | $1.5M | ||
| Q3 25 | $-9.0M | $303.8K | ||
| Q2 25 | $-3.4M | $-263.9K | ||
| Q1 25 | $-8.2M | $1.4M | ||
| Q4 24 | $-36.3M | $2.9M | ||
| Q3 24 | $-7.5M | $1.4M | ||
| Q2 24 | $-10.0M | $369.1K | ||
| Q1 24 | $-9.8M | $88.7K |
| Q4 25 | — | $1.1M | ||
| Q3 25 | — | $85.2K | ||
| Q2 25 | $-3.4M | $-503.2K | ||
| Q1 25 | $-8.3M | $1.1M | ||
| Q4 24 | $-36.4M | $2.7M | ||
| Q3 24 | $-7.5M | $1.4M | ||
| Q2 24 | $-10.0M | $246.3K | ||
| Q1 24 | $-9.8M | $-88.1K |
| Q4 25 | — | 4.8% | ||
| Q3 25 | — | 0.4% | ||
| Q2 25 | -116.5% | -2.5% | ||
| Q1 25 | -1976.7% | 4.8% | ||
| Q4 24 | -2309.3% | 13.1% | ||
| Q3 24 | -225.7% | 6.4% | ||
| Q2 24 | -376.2% | 1.2% | ||
| Q1 24 | -573.0% | -0.4% |
| Q4 25 | 0.0% | 2.0% | ||
| Q3 25 | 0.0% | 1.0% | ||
| Q2 25 | 0.9% | 1.2% | ||
| Q1 25 | 35.6% | 1.4% | ||
| Q4 24 | 4.2% | 1.0% | ||
| Q3 24 | 0.0% | 0.3% | ||
| Q2 24 | 0.4% | 0.6% | ||
| Q1 24 | 3.2% | 0.8% |
| Q4 25 | -0.68× | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 4.61× | ||
| Q3 24 | — | 0.50× | ||
| Q2 24 | — | 4.89× | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CUE
| Immuno Scape Collaboration And License Agreement | $9.5M | 43% |
| BI Collaboration And License Agreement | $8.1M | 37% |
| Other | $4.3M | 20% |
USIO
| Credit Card Revenue | $7.7M | 35% |
| ACH And Complementary Service Revenue | $6.1M | 28% |
| Output Solutions | $5.4M | 24% |
| Prepaid Card Services Revenue | $2.6M | 12% |
