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Side-by-side financial comparison of Day One Biopharmaceuticals, Inc. (DAWN) and FINANCIAL INSTITUTIONS INC (FISI). Click either name above to swap in a different company.
FINANCIAL INSTITUTIONS INC is the larger business by last-quarter revenue ($62.7M vs $39.8M, roughly 1.6× Day One Biopharmaceuticals, Inc.). FINANCIAL INSTITUTIONS INC runs the higher net margin — 33.5% vs -49.6%, a 83.1% gap on every dollar of revenue.
Day One Biopharmaceuticals is a clinical-stage biopharmaceutical firm focused on developing targeted precision oncology therapies for pediatric and young adult patients with genetically driven cancers. It advances novel drug candidates to address unmet medical needs in underserved patient segments, operating primarily in the U.S. and partnering with global oncology research institutions.
The Mizuho Financial Group, Inc. , known from 2000 to 2003 as Mizuho Holdings and abbreviated as MHFG or simply Mizuho, is a Japanese banking holding company headquartered in the Ōtemachi district of Chiyoda, Tokyo, Japan. The group was formed in 2000–2002 by merger of Dai-Ichi Kangyo Bank, Fuji Bank, and Industrial Bank of Japan. The name mizuho (瑞穂) literally means "abundant rice" in Japanese and "harvest" in the figurative sense.
DAWN vs FISI — Head-to-Head
Income Statement — Q3 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $39.8M | $62.7M |
| Net Profit | $-19.7M | $21.0M |
| Gross Margin | — | — |
| Operating Margin | -60.9% | — |
| Net Margin | -49.6% | 33.5% |
| Revenue YoY | -57.6% | — |
| Net Profit YoY | -153.3% | 24.3% |
| EPS (diluted) | $-0.19 | $1.04 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $62.7M | ||
| Q4 25 | — | $64.1M | ||
| Q3 25 | $39.8M | $63.8M | ||
| Q2 25 | $33.9M | $59.7M | ||
| Q1 25 | $30.8M | $57.2M | ||
| Q4 24 | — | $41.6M | ||
| Q3 24 | $93.8M | $50.1M | ||
| Q2 24 | — | $65.2M |
| Q1 26 | — | $21.0M | ||
| Q4 25 | — | $20.0M | ||
| Q3 25 | $-19.7M | $20.5M | ||
| Q2 25 | $-30.3M | $17.5M | ||
| Q1 25 | $-36.0M | $16.9M | ||
| Q4 24 | — | $-82.8M | ||
| Q3 24 | $37.0M | $13.5M | ||
| Q2 24 | — | $25.6M |
| Q1 26 | — | — | ||
| Q4 25 | — | 37.4% | ||
| Q3 25 | -60.9% | 39.5% | ||
| Q2 25 | -103.1% | 36.0% | ||
| Q1 25 | -133.5% | 36.0% | ||
| Q4 24 | — | -276.9% | ||
| Q3 24 | 31.6% | 29.0% | ||
| Q2 24 | — | 46.2% |
| Q1 26 | — | 33.5% | ||
| Q4 25 | — | 38.3% | ||
| Q3 25 | -49.6% | 32.1% | ||
| Q2 25 | -89.4% | 29.3% | ||
| Q1 25 | -117.0% | 29.5% | ||
| Q4 24 | — | -198.9% | ||
| Q3 24 | 39.5% | 26.9% | ||
| Q2 24 | — | 39.3% |
| Q1 26 | — | $1.04 | ||
| Q4 25 | — | $0.96 | ||
| Q3 25 | $-0.19 | $0.99 | ||
| Q2 25 | $-0.29 | $0.85 | ||
| Q1 25 | $-0.35 | $0.81 | ||
| Q4 24 | — | $-5.32 | ||
| Q3 24 | $0.38 | $0.84 | ||
| Q2 24 | — | $1.62 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $451.6M | $85.5M |
| Total DebtLower is stronger | — | $114.0M |
| Stockholders' EquityBook value | $450.9M | — |
| Total Assets | $513.8M | $6.3B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | $85.5M | ||
| Q4 25 | — | $108.8M | ||
| Q3 25 | $451.6M | $185.9M | ||
| Q2 25 | $453.1M | $93.0M | ||
| Q1 25 | $473.0M | $167.4M | ||
| Q4 24 | — | $87.3M | ||
| Q3 24 | $558.4M | — | ||
| Q2 24 | — | — |
| Q1 26 | — | $114.0M | ||
| Q4 25 | — | $193.7M | ||
| Q3 25 | — | $115.0M | ||
| Q2 25 | — | $115.0M | ||
| Q1 25 | — | $124.9M | ||
| Q4 24 | — | $124.8M | ||
| Q3 24 | — | $124.8M | ||
| Q2 24 | — | $124.7M |
| Q1 26 | — | — | ||
| Q4 25 | — | $628.9M | ||
| Q3 25 | $450.9M | $621.7M | ||
| Q2 25 | $460.8M | $601.7M | ||
| Q1 25 | $479.5M | $589.9M | ||
| Q4 24 | — | $569.0M | ||
| Q3 24 | $555.5M | $500.3M | ||
| Q2 24 | — | $467.7M |
| Q1 26 | — | $6.3B | ||
| Q4 25 | — | $6.3B | ||
| Q3 25 | $513.8M | $6.3B | ||
| Q2 25 | $519.0M | $6.1B | ||
| Q1 25 | $534.4M | $6.3B | ||
| Q4 24 | — | $6.1B | ||
| Q3 24 | $600.8M | $6.2B | ||
| Q2 24 | — | $6.1B |
| Q1 26 | — | — | ||
| Q4 25 | — | 0.31× | ||
| Q3 25 | — | 0.18× | ||
| Q2 25 | — | 0.19× | ||
| Q1 25 | — | 0.21× | ||
| Q4 24 | — | 0.22× | ||
| Q3 24 | — | 0.25× | ||
| Q2 24 | — | 0.27× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-5.8M | — |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | — | $18.8M | ||
| Q3 25 | $-5.8M | $-6.9M | ||
| Q2 25 | $-24.8M | $-5.7M | ||
| Q1 25 | $-59.0M | $10.0M | ||
| Q4 24 | — | $77.1M | ||
| Q3 24 | $50.8M | $2.1M | ||
| Q2 24 | — | $35.7M |
| Q1 26 | — | — | ||
| Q4 25 | — | $13.3M | ||
| Q3 25 | — | $-7.9M | ||
| Q2 25 | $-24.8M | $-7.3M | ||
| Q1 25 | $-59.3M | $9.2M | ||
| Q4 24 | — | $72.2M | ||
| Q3 24 | $50.0M | $-299.0K | ||
| Q2 24 | — | $34.7M |
| Q1 26 | — | — | ||
| Q4 25 | — | 20.7% | ||
| Q3 25 | — | -12.4% | ||
| Q2 25 | -73.2% | -12.3% | ||
| Q1 25 | -192.8% | 16.1% | ||
| Q4 24 | — | 173.3% | ||
| Q3 24 | 53.4% | -0.6% | ||
| Q2 24 | — | 53.3% |
| Q1 26 | — | — | ||
| Q4 25 | — | 8.7% | ||
| Q3 25 | 0.0% | 1.6% | ||
| Q2 25 | 0.0% | 2.7% | ||
| Q1 25 | 1.0% | 1.4% | ||
| Q4 24 | — | 11.9% | ||
| Q3 24 | 0.8% | 4.9% | ||
| Q2 24 | — | 1.5% |
| Q1 26 | — | — | ||
| Q4 25 | — | 0.94× | ||
| Q3 25 | — | -0.34× | ||
| Q2 25 | — | -0.33× | ||
| Q1 25 | — | 0.59× | ||
| Q4 24 | — | — | ||
| Q3 24 | 1.37× | 0.16× | ||
| Q2 24 | — | 1.39× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
DAWN
| Products | $38.5M | 97% |
| License Agreement With Ipsen Pharma Sas | $1.3M | 3% |
FISI
| Net Interest Income | $52.0M | 83% |
| Noninterest Income | $10.7M | 17% |
