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Side-by-side financial comparison of Ensysce Biosciences, Inc. (ENSC) and Rigetti Computing, Inc. (RGTI). Click either name above to swap in a different company.

Ensysce Biosciences, Inc. is the larger business by last-quarter revenue ($1.9M vs $1.9M, roughly 1.0× Rigetti Computing, Inc.). Ensysce Biosciences, Inc. runs the higher net margin — -147.0% vs -974.7%, a 827.6% gap on every dollar of revenue. On growth, Ensysce Biosciences, Inc. posted the faster year-over-year revenue change (44.4% vs -17.9%). Over the past eight quarters, Ensysce Biosciences, Inc.'s revenue compounded faster (107.9% CAGR vs -21.8%).

Ensysce Biosciences, Inc. is a clinical-stage biotechnology firm specializing in developing innovative prodrug therapies for pain management and oncology indications. Its proprietary platform is designed to reduce opioid abuse risks while enhancing treatment efficacy, targeting global healthcare and pharmaceutical markets with a focus on unmet clinical needs.

Rigetti Computing, Inc. is a Berkeley, California-based developer of superconducting quantum integrated circuits used for quantum computers. Rigetti also develops a cloud platform called Forest that enables programmers to write quantum algorithms.

ENSC vs RGTI — Head-to-Head

Bigger by revenue
ENSC
ENSC
1.0× larger
ENSC
$1.9M
$1.9M
RGTI
Growing faster (revenue YoY)
ENSC
ENSC
+62.2% gap
ENSC
44.4%
-17.9%
RGTI
Higher net margin
ENSC
ENSC
827.6% more per $
ENSC
-147.0%
-974.7%
RGTI
Faster 2-yr revenue CAGR
ENSC
ENSC
Annualised
ENSC
107.9%
-21.8%
RGTI

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
ENSC
ENSC
RGTI
RGTI
Revenue
$1.9M
$1.9M
Net Profit
$-2.8M
$-18.2M
Gross Margin
34.9%
Operating Margin
-147.8%
-1209.7%
Net Margin
-147.0%
-974.7%
Revenue YoY
44.4%
-17.9%
Net Profit YoY
22.3%
88.1%
EPS (diluted)
$-0.51
$-0.08

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ENSC
ENSC
RGTI
RGTI
Q4 25
$1.9M
$1.9M
Q3 25
$493.1K
$1.9M
Q2 25
$1.4M
$1.8M
Q1 25
$1.3M
$1.5M
Q4 24
$1.3M
$2.3M
Q3 24
$3.4M
$2.4M
Q2 24
$3.1M
Q1 24
$3.1M
Net Profit
ENSC
ENSC
RGTI
RGTI
Q4 25
$-2.8M
$-18.2M
Q3 25
$-3.7M
$-201.0M
Q2 25
$-1.7M
$-39.7M
Q1 25
$-1.9M
$42.6M
Q4 24
$-3.6M
$-153.0M
Q3 24
$661.8K
$-14.8M
Q2 24
$-12.4M
Q1 24
$-20.8M
Gross Margin
ENSC
ENSC
RGTI
RGTI
Q4 25
34.9%
Q3 25
20.7%
Q2 25
31.4%
Q1 25
30.0%
Q4 24
44.1%
Q3 24
50.6%
Q2 24
64.5%
Q1 24
49.1%
Operating Margin
ENSC
ENSC
RGTI
RGTI
Q4 25
-147.8%
-1209.7%
Q3 25
-758.7%
-1055.4%
Q2 25
-127.6%
-1103.9%
Q1 25
-149.1%
-1469.6%
Q4 24
-274.3%
-813.3%
Q3 24
18.9%
-729.4%
Q2 24
-521.2%
Q1 24
-543.4%
Net Margin
ENSC
ENSC
RGTI
RGTI
Q4 25
-147.0%
-974.7%
Q3 25
-756.3%
-10321.9%
Q2 25
-126.4%
-2201.8%
Q1 25
-147.4%
2895.3%
Q4 24
-273.4%
-6726.5%
Q3 24
19.4%
-623.8%
Q2 24
-402.5%
Q1 24
-680.6%
EPS (diluted)
ENSC
ENSC
RGTI
RGTI
Q4 25
$-0.51
$-0.08
Q3 25
$-1.29
$-0.62
Q2 25
$-0.79
$-0.13
Q1 25
$-1.39
$0.13
Q4 24
$-0.89
$-0.80
Q3 24
$1.00
$-0.08
Q2 24
$-0.07
Q1 24
$-0.14

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ENSC
ENSC
RGTI
RGTI
Cash + ST InvestmentsLiquidity on hand
$4.3M
$44.9M
Total DebtLower is stronger
Stockholders' EquityBook value
$3.2M
$546.2M
Total Assets
$7.5M
$666.6M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ENSC
ENSC
RGTI
RGTI
Q4 25
$4.3M
$44.9M
Q3 25
$1.7M
$26.1M
Q2 25
$2.2M
$57.2M
Q1 25
$3.1M
$37.2M
Q4 24
$3.5M
$67.7M
Q3 24
$4.2M
$20.3M
Q2 24
$20.7M
Q1 24
$35.1M
Stockholders' Equity
ENSC
ENSC
RGTI
RGTI
Q4 25
$3.2M
$546.2M
Q3 25
$1.2M
$371.8M
Q2 25
$3.4M
$553.3M
Q1 25
$3.0M
$207.1M
Q4 24
$3.7M
$126.6M
Q3 24
$6.9M
$122.8M
Q2 24
$122.2M
Q1 24
$115.6M
Total Assets
ENSC
ENSC
RGTI
RGTI
Q4 25
$7.5M
$666.6M
Q3 25
$3.2M
$630.3M
Q2 25
$5.6M
$636.7M
Q1 25
$4.6M
$269.1M
Q4 24
$5.6M
$284.8M
Q3 24
$9.4M
$157.3M
Q2 24
$162.4M
Q1 24
$162.1M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ENSC
ENSC
RGTI
RGTI
Operating Cash FlowLast quarter
$-1.5M
$-14.9M
Free Cash FlowOCF − Capex
$-19.5M
FCF MarginFCF / Revenue
-1042.5%
Capex IntensityCapex / Revenue
244.8%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$-77.2M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ENSC
ENSC
RGTI
RGTI
Q4 25
$-1.5M
$-14.9M
Q3 25
$-1.9M
$-13.8M
Q2 25
$-2.7M
$-16.2M
Q1 25
$-1.7M
$-13.7M
Q4 24
$-764.1K
$-8.5M
Q3 24
$-1.0M
$-15.4M
Q2 24
$-13.5M
Q1 24
$-13.1M
Free Cash Flow
ENSC
ENSC
RGTI
RGTI
Q4 25
$-19.5M
Q3 25
$-19.7M
Q2 25
$-21.8M
Q1 25
$-16.2M
Q4 24
$-9.8M
Q3 24
$-17.7M
Q2 24
$-15.6M
Q1 24
$-18.6M
FCF Margin
ENSC
ENSC
RGTI
RGTI
Q4 25
-1042.5%
Q3 25
-1012.4%
Q2 25
-1212.4%
Q1 25
-1100.4%
Q4 24
-432.1%
Q3 24
-744.5%
Q2 24
-504.3%
Q1 24
-610.5%
Capex Intensity
ENSC
ENSC
RGTI
RGTI
Q4 25
244.8%
Q3 25
302.5%
Q2 25
314.7%
Q1 25
173.0%
Q4 24
56.4%
Q3 24
95.8%
Q2 24
66.3%
Q1 24
180.0%
Cash Conversion
ENSC
ENSC
RGTI
RGTI
Q4 25
Q3 25
Q2 25
Q1 25
-0.32×
Q4 24
Q3 24
-1.54×
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ENSC
ENSC

Segment breakdown not available.

RGTI
RGTI

Collaborative Research And Other Professional Services$1.7M93%
Other$131.0K7%

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