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Side-by-side financial comparison of ESTABLISHMENT LABS HOLDINGS INC. (ESTA) and STEM, INC. (STEM). Click either name above to swap in a different company.
ESTABLISHMENT LABS HOLDINGS INC. is the larger business by last-quarter revenue ($64.6M vs $47.1M, roughly 1.4× STEM, INC.). On growth, ESTABLISHMENT LABS HOLDINGS INC. posted the faster year-over-year revenue change (45.2% vs -15.6%). Over the past eight quarters, STEM, INC.'s revenue compounded faster (36.1% CAGR vs 31.9%).
Astera Labs, Inc. is an American fabless semiconductor manufacturer and artificial intelligence company. The company specializes in designing high-speed connectivity solutions for data centers and AI infrastructure. The company has been listed on the Nasdaq since March 2024.
StemCells, Inc. is a public biopharmaceutical company headquartered in Newark, California, that is developing purified human neural stem cells (HuCNS-SCs) in the hopes of treating central nervous system disorders and paralysis. StemCells' HuCNS-SCs have the ability to differentiate into the three main types of cells found in the central nervous system: neurons, astrocytes and oligodendrocytes.
ESTA vs STEM — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $64.6M | $47.1M |
| Net Profit | — | $-16.0M |
| Gross Margin | 70.5% | 48.9% |
| Operating Margin | -6.1% | -17.7% |
| Net Margin | — | -33.9% |
| Revenue YoY | 45.2% | -15.6% |
| Net Profit YoY | — | 68.8% |
| EPS (diluted) | $-0.07 | $-4.40 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $64.6M | $47.1M | ||
| Q3 25 | $53.8M | $38.2M | ||
| Q2 25 | $51.3M | $38.4M | ||
| Q1 25 | $41.4M | $32.5M | ||
| Q4 24 | $44.5M | $55.8M | ||
| Q3 24 | $40.2M | $29.3M | ||
| Q2 24 | $44.1M | $34.0M | ||
| Q1 24 | $37.2M | $25.5M |
| Q4 25 | — | $-16.0M | ||
| Q3 25 | $-11.1M | $-23.8M | ||
| Q2 25 | $-16.6M | $202.5M | ||
| Q1 25 | $-20.7M | $-25.0M | ||
| Q4 24 | — | $-51.1M | ||
| Q3 24 | $-16.7M | $-148.3M | ||
| Q2 24 | $-17.2M | $-582.3M | ||
| Q1 24 | $-16.2M | $-72.3M |
| Q4 25 | 70.5% | 48.9% | ||
| Q3 25 | 70.1% | 35.5% | ||
| Q2 25 | 68.8% | 33.4% | ||
| Q1 25 | 67.2% | 32.4% | ||
| Q4 24 | 68.5% | -4.4% | ||
| Q3 24 | 63.9% | 21.2% | ||
| Q2 24 | 65.6% | 27.6% | ||
| Q1 24 | 65.6% | -95.0% |
| Q4 25 | -6.1% | -17.7% | ||
| Q3 25 | -7.5% | -33.6% | ||
| Q2 25 | -27.5% | -34.8% | ||
| Q1 25 | -41.0% | -65.0% | ||
| Q4 24 | -41.9% | -84.4% | ||
| Q3 24 | -32.7% | -493.2% | ||
| Q2 24 | -21.2% | -1705.5% | ||
| Q1 24 | -23.8% | -267.0% |
| Q4 25 | — | -33.9% | ||
| Q3 25 | -20.7% | -62.2% | ||
| Q2 25 | -32.3% | 527.8% | ||
| Q1 25 | -50.1% | -76.9% | ||
| Q4 24 | — | -91.6% | ||
| Q3 24 | -41.5% | -506.3% | ||
| Q2 24 | -38.9% | -1712.6% | ||
| Q1 24 | -43.6% | -283.9% |
| Q4 25 | $-0.07 | $-4.40 | ||
| Q3 25 | $-0.38 | $-2.84 | ||
| Q2 25 | $-0.57 | $-1.79 | ||
| Q1 25 | $-0.70 | $-0.15 | ||
| Q4 24 | $-1.21 | $-15.29 | ||
| Q3 24 | $-0.59 | $-18.24 | ||
| Q2 24 | $-0.62 | $-71.81 | ||
| Q1 24 | $-0.58 | $-0.46 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $75.6M | $48.9M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $23.5M | $-249.4M |
| Total Assets | $357.2M | $308.9M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $75.6M | $48.9M | ||
| Q3 25 | $70.6M | $43.1M | ||
| Q2 25 | $54.6M | $40.8M | ||
| Q1 25 | $69.2M | $58.6M | ||
| Q4 24 | $90.3M | $56.3M | ||
| Q3 24 | — | $75.4M | ||
| Q2 24 | — | $89.6M | ||
| Q1 24 | — | $112.8M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $0 | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $23.5M | $-249.4M | ||
| Q3 25 | $16.4M | $-235.7M | ||
| Q2 25 | $22.8M | $-214.1M | ||
| Q1 25 | $38.5M | $-417.5M | ||
| Q4 24 | $53.1M | $-398.4M | ||
| Q3 24 | $32.7M | $-344.1M | ||
| Q2 24 | $45.0M | $-203.2M | ||
| Q1 24 | $56.9M | $371.6M |
| Q4 25 | $357.2M | $308.9M | ||
| Q3 25 | $338.9M | $362.6M | ||
| Q2 25 | $329.7M | $379.2M | ||
| Q1 25 | $333.4M | $405.1M | ||
| Q4 24 | $346.8M | $437.4M | ||
| Q3 24 | $282.7M | $537.8M | ||
| Q2 24 | $285.1M | $691.5M | ||
| Q1 24 | $301.8M | $1.3B |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 0.00× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-162.0K | $8.2M |
| Free Cash FlowOCF − Capex | $-2.0M | — |
| FCF MarginFCF / Revenue | -3.1% | — |
| Capex IntensityCapex / Revenue | 2.8% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-56.9M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-162.0K | $8.2M | ||
| Q3 25 | $-11.3M | $11.4M | ||
| Q2 25 | $-18.8M | $-21.3M | ||
| Q1 25 | $-20.7M | $8.5M | ||
| Q4 24 | $-20.7M | $-14.7M | ||
| Q3 24 | $-12.5M | $-9.4M | ||
| Q2 24 | $-14.2M | $-11.9M | ||
| Q1 24 | $-11.2M | $-621.0K |
| Q4 25 | $-2.0M | — | ||
| Q3 25 | $-13.1M | — | ||
| Q2 25 | $-20.4M | — | ||
| Q1 25 | $-21.5M | — | ||
| Q4 24 | $-21.3M | — | ||
| Q3 24 | $-13.9M | — | ||
| Q2 24 | $-15.0M | — | ||
| Q1 24 | $-14.5M | — |
| Q4 25 | -3.1% | — | ||
| Q3 25 | -24.4% | — | ||
| Q2 25 | -39.7% | — | ||
| Q1 25 | -51.9% | — | ||
| Q4 24 | -47.8% | — | ||
| Q3 24 | -34.6% | — | ||
| Q2 24 | -33.9% | — | ||
| Q1 24 | -38.9% | — |
| Q4 25 | 2.8% | — | ||
| Q3 25 | 3.4% | — | ||
| Q2 25 | 3.2% | — | ||
| Q1 25 | 1.8% | — | ||
| Q4 24 | 1.2% | — | ||
| Q3 24 | 3.7% | — | ||
| Q2 24 | 1.8% | — | ||
| Q1 24 | 8.9% | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | -0.11× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
