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Side-by-side financial comparison of HARVARD BIOSCIENCE INC (HBIO) and PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (PACB). Click either name above to swap in a different company.
PACIFIC BIOSCIENCES OF CALIFORNIA, INC. is the larger business by last-quarter revenue ($44.6M vs $23.7M, roughly 1.9× HARVARD BIOSCIENCE INC). HARVARD BIOSCIENCE INC runs the higher net margin — -12.0% vs -90.4%, a 78.4% gap on every dollar of revenue. On growth, PACIFIC BIOSCIENCES OF CALIFORNIA, INC. posted the faster year-over-year revenue change (13.8% vs -3.3%). HARVARD BIOSCIENCE INC produced more free cash flow last quarter ($-545.0K vs $-19.9M). Over the past eight quarters, PACIFIC BIOSCIENCES OF CALIFORNIA, INC.'s revenue compounded faster (7.3% CAGR vs -1.6%).
Harvard Bioscience is a global developer, manufacturer and marketer of life sciences equipment to support research and drug discovery. It is traded on NASDAQ under the stock symbol HBIO.
Pacific Biosciences of California, Inc. is an American biotechnology company founded in 2004 that develops and manufactures systems for gene sequencing and some novel real time biological observation. PacBio has two principal sequencing platforms: single-molecule real-time sequencing (SMRT), based on the properties of zero-mode waveguides and sequencing by binding (SBB) chemistry, which uses native nucleotides and scarless incorporation for DNA binding and extension.
HBIO vs PACB — Head-to-Head
Income Statement — Q4 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $23.7M | $44.6M |
| Net Profit | $-2.8M | $-40.4M |
| Gross Margin | 59.7% | 37.1% |
| Operating Margin | 7.2% | -92.3% |
| Net Margin | -12.0% | -90.4% |
| Revenue YoY | -3.3% | 13.8% |
| Net Profit YoY | -15916.7% | -1802.7% |
| EPS (diluted) | $-0.06 | $-0.11 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $23.7M | $44.6M | ||
| Q3 25 | $20.6M | $38.4M | ||
| Q2 25 | $20.4M | $39.8M | ||
| Q1 25 | $21.8M | $37.2M | ||
| Q4 24 | $24.6M | $39.2M | ||
| Q3 24 | $22.0M | $40.0M | ||
| Q2 24 | $23.1M | $36.0M | ||
| Q1 24 | $24.5M | $38.8M |
| Q4 25 | $-2.8M | $-40.4M | ||
| Q3 25 | $-1.2M | $-38.0M | ||
| Q2 25 | $-2.3M | $-41.9M | ||
| Q1 25 | $-50.3M | $-426.1M | ||
| Q4 24 | $18.0K | $2.4M | ||
| Q3 24 | $-4.8M | $-60.7M | ||
| Q2 24 | $-2.9M | $-173.3M | ||
| Q1 24 | $-4.7M | $-78.2M |
| Q4 25 | 59.7% | 37.1% | ||
| Q3 25 | 58.4% | 41.4% | ||
| Q2 25 | 56.4% | 36.9% | ||
| Q1 25 | 56.0% | -3.7% | ||
| Q4 24 | 57.1% | 25.6% | ||
| Q3 24 | 58.1% | 25.0% | ||
| Q2 24 | 57.2% | 16.5% | ||
| Q1 24 | 60.3% | 29.1% |
| Q4 25 | 7.2% | -92.3% | ||
| Q3 25 | 1.0% | -101.1% | ||
| Q2 25 | -4.0% | -112.8% | ||
| Q1 25 | -228.1% | -1154.5% | ||
| Q4 24 | 0.0% | -390.1% | ||
| Q3 24 | -8.5% | -160.3% | ||
| Q2 24 | -9.0% | -488.3% | ||
| Q1 24 | -9.3% | -209.6% |
| Q4 25 | -12.0% | -90.4% | ||
| Q3 25 | -6.0% | -98.9% | ||
| Q2 25 | -11.2% | -105.4% | ||
| Q1 25 | -231.2% | -1146.8% | ||
| Q4 24 | 0.1% | 6.0% | ||
| Q3 24 | -21.9% | -151.9% | ||
| Q2 24 | -12.7% | -481.3% | ||
| Q1 24 | -19.1% | -201.4% |
| Q4 25 | $-0.06 | $-0.11 | ||
| Q3 25 | $-0.03 | $-0.13 | ||
| Q2 25 | $-0.05 | $-0.14 | ||
| Q1 25 | $-1.14 | $-1.44 | ||
| Q4 24 | $0.01 | $-0.44 | ||
| Q3 24 | $-0.11 | $-0.22 | ||
| Q2 24 | $-0.07 | $-0.64 | ||
| Q1 24 | $-0.11 | $-0.29 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $8.6M | $279.5M |
| Total DebtLower is stronger | $35.9M | — |
| Stockholders' EquityBook value | $13.7M | $5.3M |
| Total Assets | $80.1M | $784.1M |
| Debt / EquityLower = less leverage | 2.61× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $8.6M | $279.5M | ||
| Q3 25 | $6.8M | $298.7M | ||
| Q2 25 | $7.4M | $314.7M | ||
| Q1 25 | $5.5M | $343.1M | ||
| Q4 24 | $4.1M | $389.9M | ||
| Q3 24 | $4.6M | $471.1M | ||
| Q2 24 | $4.0M | $509.8M | ||
| Q1 24 | $4.3M | $561.9M |
| Q4 25 | $35.9M | — | ||
| Q3 25 | $34.0M | — | ||
| Q2 25 | $34.9M | — | ||
| Q1 25 | $36.4M | — | ||
| Q4 24 | $37.0M | — | ||
| Q3 24 | $34.9M | — | ||
| Q2 24 | $35.7M | — | ||
| Q1 24 | $35.6M | — |
| Q4 25 | $13.7M | $5.3M | ||
| Q3 25 | $14.1M | $36.1M | ||
| Q2 25 | $15.7M | $61.5M | ||
| Q1 25 | $14.8M | $91.6M | ||
| Q4 24 | $63.3M | $506.6M | ||
| Q3 24 | $65.3M | $453.1M | ||
| Q2 24 | $67.2M | $492.7M | ||
| Q1 24 | $68.8M | $649.0M |
| Q4 25 | $80.1M | $784.1M | ||
| Q3 25 | $78.0M | $803.2M | ||
| Q2 25 | $80.1M | $825.5M | ||
| Q1 25 | $79.8M | $860.8M | ||
| Q4 24 | $126.6M | $1.3B | ||
| Q3 24 | $131.2M | $1.5B | ||
| Q2 24 | $128.9M | $1.5B | ||
| Q1 24 | $133.2M | $1.7B |
| Q4 25 | 2.61× | — | ||
| Q3 25 | 2.41× | — | ||
| Q2 25 | 2.22× | — | ||
| Q1 25 | 2.45× | — | ||
| Q4 24 | 0.58× | — | ||
| Q3 24 | 0.53× | — | ||
| Q2 24 | 0.53× | — | ||
| Q1 24 | 0.52× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-96.0K | $-19.1M |
| Free Cash FlowOCF − Capex | $-545.0K | $-19.9M |
| FCF MarginFCF / Revenue | -2.3% | -44.6% |
| Capex IntensityCapex / Revenue | 1.9% | 1.9% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $5.5M | $-114.1M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-96.0K | $-19.1M | ||
| Q3 25 | $1.1M | $-18.7M | ||
| Q2 25 | $2.8M | $-29.4M | ||
| Q1 25 | $3.0M | $-44.1M | ||
| Q4 24 | $1.7M | $-30.6M | ||
| Q3 24 | $-842.0K | $-45.5M | ||
| Q2 24 | $-846.0K | $-54.3M | ||
| Q1 24 | $1.4M | $-75.7M |
| Q4 25 | $-545.0K | $-19.9M | ||
| Q3 25 | $877.0K | $-18.8M | ||
| Q2 25 | $2.7M | $-29.9M | ||
| Q1 25 | $2.5M | $-45.4M | ||
| Q4 24 | $1.4M | $-32.3M | ||
| Q3 24 | $-1.7M | $-46.3M | ||
| Q2 24 | $-1.7M | $-55.7M | ||
| Q1 24 | $758.0K | $-79.6M |
| Q4 25 | -2.3% | -44.6% | ||
| Q3 25 | 4.3% | -48.9% | ||
| Q2 25 | 13.0% | -75.3% | ||
| Q1 25 | 11.4% | -122.3% | ||
| Q4 24 | 5.8% | -82.3% | ||
| Q3 24 | -7.8% | -115.7% | ||
| Q2 24 | -7.2% | -154.8% | ||
| Q1 24 | 3.1% | -205.0% |
| Q4 25 | 1.9% | 1.9% | ||
| Q3 25 | 1.0% | 0.2% | ||
| Q2 25 | 0.4% | 1.4% | ||
| Q1 25 | 2.4% | 3.7% | ||
| Q4 24 | 1.2% | 4.1% | ||
| Q3 24 | 4.0% | 2.0% | ||
| Q2 24 | 3.5% | 4.1% | ||
| Q1 24 | 2.6% | 10.0% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 95.83× | -12.93× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
HBIO
| Instruments Equipment Software And Accessories | $21.6M | 91% |
| Service Maintenance And Warranty Contracts | $2.1M | 9% |
PACB
| Products | $39.0M | 87% |
| Service And Other | $5.7M | 13% |
