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Side-by-side financial comparison of Karyopharm Therapeutics Inc. (KPTI) and Pioneer Bancorp, Inc. (PBFS). Click either name above to swap in a different company.
Karyopharm Therapeutics Inc. is the larger business by last-quarter revenue ($34.1M vs $25.0M, roughly 1.4× Pioneer Bancorp, Inc.). Pioneer Bancorp, Inc. runs the higher net margin — 82.1% vs -299.9%, a 382.0% gap on every dollar of revenue. Over the past eight quarters, Pioneer Bancorp, Inc.'s revenue compounded faster (144.9% CAGR vs 1.4%).
Pioneer Bancorp, Inc. (MD) is a bank holding company operating as the parent entity of Pioneer Bank. It provides a full suite of retail and commercial banking products and services, including deposit accounts, residential and commercial mortgages, consumer loans, and small business financing, primarily serving individual and corporate customers across local communities in Maryland, U.S.
KPTI vs PBFS — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $34.1M | $25.0M |
| Net Profit | $-102.2M | $3.7M |
| Gross Margin | — | — |
| Operating Margin | -52.4% | 21.3% |
| Net Margin | -299.9% | 82.1% |
| Revenue YoY | 11.6% | — |
| Net Profit YoY | -232.0% | — |
| EPS (diluted) | $-7.02 | $0.16 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $34.1M | $25.0M | ||
| Q3 25 | $44.0M | $24.0M | ||
| Q2 25 | $37.9M | $24.4M | ||
| Q1 25 | $30.0M | $22.8M | ||
| Q4 24 | $30.5M | — | ||
| Q3 24 | $38.8M | $22.0M | ||
| Q2 24 | $42.8M | $20.9M | ||
| Q1 24 | $33.1M | $21.6M |
| Q4 25 | $-102.2M | $3.7M | ||
| Q3 25 | $-33.1M | $4.3M | ||
| Q2 25 | $-37.3M | $6.5M | ||
| Q1 25 | $-23.5M | $5.8M | ||
| Q4 24 | $-30.8M | — | ||
| Q3 24 | $-32.1M | $6.3M | ||
| Q2 24 | $23.8M | $3.9M | ||
| Q1 24 | $-37.4M | $4.7M |
| Q4 25 | -52.4% | 21.3% | ||
| Q3 25 | -34.6% | 23.4% | ||
| Q2 25 | -64.3% | 33.3% | ||
| Q1 25 | -110.8% | 32.5% | ||
| Q4 24 | -102.4% | — | ||
| Q3 24 | -67.8% | 37.2% | ||
| Q2 24 | -65.7% | 24.1% | ||
| Q1 24 | -101.9% | 28.1% |
| Q4 25 | -299.9% | 82.1% | ||
| Q3 25 | -75.2% | 18.0% | ||
| Q2 25 | -98.2% | 26.4% | ||
| Q1 25 | -78.2% | 25.3% | ||
| Q4 24 | -100.8% | — | ||
| Q3 24 | -82.7% | 28.7% | ||
| Q2 24 | 55.6% | 107.4% | ||
| Q1 24 | -112.8% | 21.9% |
| Q4 25 | $-7.02 | $0.16 | ||
| Q3 25 | $-3.82 | $0.18 | ||
| Q2 25 | $-4.32 | $0.26 | ||
| Q1 25 | $-2.77 | $0.23 | ||
| Q4 24 | $-2.33 | — | ||
| Q3 24 | $-3.85 | $0.25 | ||
| Q2 24 | $-2.97 | $0.15 | ||
| Q1 24 | $-4.85 | $0.19 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $60.5M | — |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $-292.9M | $323.9M |
| Total Assets | $108.4M | $2.2B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $60.5M | — | ||
| Q3 25 | $37.7M | — | ||
| Q2 25 | $38.7M | — | ||
| Q1 25 | $38.8M | — | ||
| Q4 24 | $62.5M | — | ||
| Q3 24 | $72.8M | — | ||
| Q2 24 | $84.8M | — | ||
| Q1 24 | $30.6M | — |
| Q4 25 | $-292.9M | $323.9M | ||
| Q3 25 | $-269.3M | $314.2M | ||
| Q2 25 | $-238.9M | $314.2M | ||
| Q1 25 | $-205.9M | $310.7M | ||
| Q4 24 | $-186.0M | — | ||
| Q3 24 | $-159.6M | $303.8M | ||
| Q2 24 | $-132.1M | $296.5M | ||
| Q1 24 | $-169.0M | $289.0M |
| Q4 25 | $108.4M | $2.2B | ||
| Q3 25 | $96.2M | $2.2B | ||
| Q2 25 | $104.9M | $2.1B | ||
| Q1 25 | $127.7M | $2.1B | ||
| Q4 24 | $164.4M | — | ||
| Q3 24 | $189.5M | $2.0B | ||
| Q2 24 | $214.0M | — | ||
| Q1 24 | $204.5M | $2.0B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-11.8M | $11.1M |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | — | 2.97× |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-11.8M | $11.1M | ||
| Q3 25 | $-5.9M | $3.9M | ||
| Q2 25 | $-18.7M | $5.1M | ||
| Q1 25 | $-39.0M | $-3.5M | ||
| Q4 24 | $-25.8M | — | ||
| Q3 24 | $-19.5M | $1.9M | ||
| Q2 24 | $-38.5M | $9.0M | ||
| Q1 24 | $-43.7M | $3.3M |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $-25.9M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | $-43.9M | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | -84.7% | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | -132.6% | — |
| Q4 25 | 0.0% | — | ||
| Q3 25 | 0.0% | — | ||
| Q2 25 | 0.0% | — | ||
| Q1 25 | 0.0% | — | ||
| Q4 24 | 0.2% | — | ||
| Q3 24 | 0.0% | — | ||
| Q2 24 | 0.0% | — | ||
| Q1 24 | 0.6% | — |
| Q4 25 | — | 2.97× | ||
| Q3 25 | — | 0.90× | ||
| Q2 25 | — | 0.78× | ||
| Q1 25 | — | -0.61× | ||
| Q4 24 | — | — | ||
| Q3 24 | — | 0.30× | ||
| Q2 24 | -1.62× | 2.30× | ||
| Q1 24 | — | 0.70× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
KPTI
| Products | $32.1M | 94% |
| License And Other | $2.0M | 6% |
PBFS
Segment breakdown not available.
