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Side-by-side financial comparison of Krystal Biotech, Inc. (KRYS) and Revolution Medicines, Inc. (RVMD). Click either name above to swap in a different company.
Krystal Biotech, Inc. produced more free cash flow last quarter ($75.4M vs $-139.5M). Over the past eight quarters, Krystal Biotech, Inc.'s revenue compounded faster (53.8% CAGR vs -100.0%).
Krystal Biotech, Inc. is a clinical-stage biotechnology company specializing in the research, development and commercialization of novel gene therapies for rare, serious dermatological diseases with high unmet medical needs. It primarily serves patients across North America and Europe, focusing on monogenic skin disorders that lack effective standard treatment options.
Tempus AI, Inc. is an American health technology company founded in 2015 by Eric Lefkofsky in Chicago, Illinois. It was established by Lefkofsky soon after his wife was diagnosed with breast cancer. Tempus uses data and artificial intelligence (AI) to create precision medicine services, including diagnostics, for oncology, cardiology, radiology, and depression. The company went public on the Nasdaq on June 14, 2024, under the ticker symbol "TEM."
KRYS vs RVMD — Head-to-Head
Income Statement — Q4 2025 vs Q4 2024
| Metric | | |
|---|---|---|
| Revenue | $107.1M | $0 |
| Net Profit | $51.4M | $-194.6M |
| Gross Margin | — | — |
| Operating Margin | 41.5% | — |
| Net Margin | 48.0% | — |
| Revenue YoY | 17.5% | — |
| Net Profit YoY | 13.0% | -20.4% |
| EPS (diluted) | $1.69 | $-1.13 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $107.1M | — | ||
| Q3 25 | $97.8M | — | ||
| Q2 25 | $96.0M | — | ||
| Q1 25 | $88.2M | — | ||
| Q4 24 | $91.1M | $0 | ||
| Q3 24 | $83.8M | $0 | ||
| Q2 24 | $70.3M | $0 | ||
| Q1 24 | $45.3M | $0 |
| Q4 25 | $51.4M | — | ||
| Q3 25 | $79.4M | — | ||
| Q2 25 | $38.3M | — | ||
| Q1 25 | $35.7M | — | ||
| Q4 24 | $45.5M | $-194.6M | ||
| Q3 24 | $27.2M | $-156.3M | ||
| Q2 24 | $15.6M | $-133.2M | ||
| Q1 24 | $932.0K | $-116.0M |
| Q4 25 | 41.5% | — | ||
| Q3 25 | 42.3% | — | ||
| Q2 25 | 40.9% | — | ||
| Q1 25 | 41.0% | — | ||
| Q4 24 | 45.4% | — | ||
| Q3 24 | 26.8% | — | ||
| Q2 24 | 12.2% | — | ||
| Q1 24 | -14.8% | — |
| Q4 25 | 48.0% | — | ||
| Q3 25 | 81.2% | — | ||
| Q2 25 | 39.9% | — | ||
| Q1 25 | 40.5% | — | ||
| Q4 24 | 49.9% | — | ||
| Q3 24 | 32.4% | — | ||
| Q2 24 | 22.2% | — | ||
| Q1 24 | 2.1% | — |
| Q4 25 | $1.69 | — | ||
| Q3 25 | $2.66 | — | ||
| Q2 25 | $1.29 | — | ||
| Q1 25 | $1.20 | — | ||
| Q4 24 | $1.53 | $-1.13 | ||
| Q3 24 | $0.91 | $-0.94 | ||
| Q2 24 | $0.53 | $-0.81 | ||
| Q1 24 | $0.03 | $-0.70 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $496.3M | $2.3B |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $1.2B | $2.3B |
| Total Assets | $1.3B | $2.6B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $496.3M | — | ||
| Q3 25 | $392.6M | — | ||
| Q2 25 | $353.8M | — | ||
| Q1 25 | $308.8M | — | ||
| Q4 24 | $344.9M | $2.3B | ||
| Q3 24 | $374.0M | $1.5B | ||
| Q2 24 | $345.8M | $1.6B | ||
| Q1 24 | $359.0M | $1.7B |
| Q4 25 | $1.2B | — | ||
| Q3 25 | $1.1B | — | ||
| Q2 25 | $1.0B | — | ||
| Q1 25 | $984.7M | — | ||
| Q4 24 | $946.4M | $2.3B | ||
| Q3 24 | $885.8M | $1.6B | ||
| Q2 24 | $838.9M | $1.6B | ||
| Q1 24 | $799.2M | $1.7B |
| Q4 25 | $1.3B | — | ||
| Q3 25 | $1.2B | — | ||
| Q2 25 | $1.1B | — | ||
| Q1 25 | $1.1B | — | ||
| Q4 24 | $1.1B | $2.6B | ||
| Q3 24 | $982.3M | $1.8B | ||
| Q2 24 | $917.7M | $1.8B | ||
| Q1 24 | $853.3M | $1.9B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $77.5M | $-138.3M |
| Free Cash FlowOCF − Capex | $75.4M | $-139.5M |
| FCF MarginFCF / Revenue | 70.4% | — |
| Capex IntensityCapex / Revenue | 2.0% | — |
| Cash ConversionOCF / Net Profit | 1.51× | — |
| TTM Free Cash FlowTrailing 4 quarters | $188.9M | $-567.7M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $77.5M | — | ||
| Q3 25 | $39.7M | — | ||
| Q2 25 | $52.7M | — | ||
| Q1 25 | $31.0M | — | ||
| Q4 24 | $52.8M | $-138.3M | ||
| Q3 24 | $58.9M | $-130.4M | ||
| Q2 24 | $-4.2M | $-128.2M | ||
| Q1 24 | $15.9M | $-160.6M |
| Q4 25 | $75.4M | — | ||
| Q3 25 | $38.0M | — | ||
| Q2 25 | $50.8M | — | ||
| Q1 25 | $24.8M | — | ||
| Q4 24 | $52.0M | $-139.5M | ||
| Q3 24 | $57.8M | $-133.9M | ||
| Q2 24 | $-5.3M | $-130.6M | ||
| Q1 24 | $14.6M | $-163.7M |
| Q4 25 | 70.4% | — | ||
| Q3 25 | 38.8% | — | ||
| Q2 25 | 52.9% | — | ||
| Q1 25 | 28.1% | — | ||
| Q4 24 | 57.1% | — | ||
| Q3 24 | 69.0% | — | ||
| Q2 24 | -7.5% | — | ||
| Q1 24 | 32.3% | — |
| Q4 25 | 2.0% | — | ||
| Q3 25 | 1.7% | — | ||
| Q2 25 | 2.0% | — | ||
| Q1 25 | 7.0% | — | ||
| Q4 24 | 0.9% | — | ||
| Q3 24 | 1.2% | — | ||
| Q2 24 | 1.6% | — | ||
| Q1 24 | 2.8% | — |
| Q4 25 | 1.51× | — | ||
| Q3 25 | 0.50× | — | ||
| Q2 25 | 1.38× | — | ||
| Q1 25 | 0.87× | — | ||
| Q4 24 | 1.16× | — | ||
| Q3 24 | 2.17× | — | ||
| Q2 24 | -0.27× | — | ||
| Q1 24 | 17.05× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
